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Effect of beta-carotene on epithelio-mesenchymal interaction during ocbntogenesis and oncogenesis in NMU-treated hamster

Research Project

Project/Area Number 06671800
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

KOHGO Takao  Sch.of Dent., Hokkaido Univ., Asso.Prof., 歯学部, 助教授 (80001949)

Co-Investigator(Kenkyū-buntansha) SHINDOH Masanobu  Sch.of Dent., Hokkaido Univ., Asst., 歯学部, 助手 (20162802)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsOdontogenic tumor / beta-carotene / Disturbances in odontogenesis / Hamster / N-nitrosomethylurea / 上皮間葉相互作用 / 歯方形成異常 / N-nitrosomethylurea / 上皮-間葉相互作用
Research Abstract

We have reported the induction of disturbances in odontogenesis and odontogenic tumors in incisors of NMU-treated hamsters, and also demonstrated the effects of vitamin A on tumorigenesis and disturbances in odontogenesis. In the present study, we investigated the effect of natural and synthetic beta-carotene on NMU-treated hamsters. Six hours after administration of beta-carotenes, NMU treatment was conducted twice a week for three months. The NMU-induced disturbances in the odontogenesis of mandibular incisors were characterized by hypoplastic changes ranging from enamel hypoplasia to loss of enamel and irregular hypoplastic dentin formation. In NMU-treated hamsters, excess administration of beta-carotene slightly repressed disturbances in odontogenesis, atypical proliferation of odontogenic epithelium, and keratinization of epithelial components. In NMU inhibited ameloblast differentiation, the differentiation on odontoblasts and cell to cell contact between preameloblasts and odontoblasts were not prevented. The beta-carotene did not prevent NMU-induced inhibition of ameloblast differentiation but inhibited NMU-induced keratinization of odontogenic epithelium. The beta-carotene had a moderate suppressive effect on the development of the odontogenic tumors. Synthetic beta-carotene seems to be slightly more effective on NMU-induced disturbances in odontogenesis than natural beta-carotene. The beta-carotene may play a role in the normal differentiation of odontogenic epithelial tissue as a biological function and as a provitamin A function. This study may suggest inhibitory effects of beta-carotene on odontogenic tumor development as a biological function rather than as a provitamin A function.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 向後隆男、Bernard T.Acob、飯塚正、進藤正信、雨宮璋: "歯原性腫瘍および歯の形成異常発生に及ぼす天然・合成β-カロテンの影響に関する病理組織学敵研究" 北海道歯学会雑誌. 17. 62-71 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takao Kohgo, Bernard T.Acob, Tadashi lizuka, Masanobu Shindoh and Akira Amemiya: "Histopath ologic evaluation of the effect of natural and synthetic beta-carotene on tumorigenesis and disturbances in odontogenesis in N-nitrosomethylurea-treated hamsters." Hokkaido J.Dent.Sci.17. 62-71 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takao KOHGO et al.: "Histopathologic studies on the pothogenesis of odontogenic tumors and distwbance in odontogenesis in hamsters treated wifh N-metbylnitresourea." 北海道歯学雑誌. 15(1). 209-210 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 向後隆男: "ビタミンAとβカロテンの役割" 北海道歯学雑誌. 15(2). 386-387 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 向後隆男: "ビタミンAとβ-カロテンの役割" 北海道歯学会雑誌. 15. 386-387 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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