| Project/Area Number |
06671876
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SATOH Takafumi Hokkaido Univ.School of Dentistry, Instructor, 歯学部, 助手 (80178748)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | hyperthermia / finite element method / tumor blood flow / ハイパーサーミア / 腫瘍血管 / 温度分布 |
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| Research Abstract |
I studied temperature distribution of tumor vessels and their periphery during microwave hyperthermia by finite element method.
(METHOD) : I adopted data from the paper of M.W.Dewhirst, et al.as "vessel diameter" and "average distance between vessels" (tumor vessel diameter is 50mu, average distance between vessels is 300mu) I supposed vessels run parallel to each other. I also supposed the temperature of the center of line between vessels is highest. I used 452 nodal points and 808 elements. As boundary conditions a temperature of inner wall of vessels is 37ﾟC,and that of margin of the region is 43ﾟC.
(RESULTS) : The temperature distribution I got was approximately circles which have common centers. At the vessel, a temperature gradient was 0.10ﾟC/mu. If I suppose thickness of cells of tumor vessels is 10mu, a temperature of cells of tumor vessel is 37-38ﾟC.
(DISCUSSION) : I recognized that the temperature of tumor vessels is lower than that of sensors. Therefore a heat effect on tumor vessels could decrease. This fact might be one of causes that hyperthermia is not so effective as we expect.
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