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Efficacy of new mono-methacrylate esters as a dentin primer

Research Project

Project/Area Number 06671925
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionShowa University

Principal Investigator

HASEGAWA Tokuji  Showa University, School of Dentistry, Operative Dentistry ; Assistant Professor, 歯学部, 講師 (10180861)

Co-Investigator(Kenkyū-buntansha) MIYASAKA Tadashi  Showa University, School of Pharmaceutical Sciences, Medicinal and Synthetical C, 薬学部, 教授 (70053808)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsDentin Bonding / Dentin Primer / Esterified Methacrylate / xylitol / Contraction Gap / Tensile Bond Strength / デンティンプライマー / メタクリル酸エステル / NMR(磁気共鳴スペクトル)
Research Abstract

Some esterified methacrylate with polyvalent alcohol such as glyceryl methacrylate and erythritol methacrylate, have been developed and reported as effective dentin primers. The purpose of this study was to synthesize a new esterified methacrylate monomer, xylitol mono-methacrylate (2, 3, 4, 5-tetrahydroxypentyl methacrylate : XM) to avoid the possible side effect on the skin tissue, and to determine the bonding efficacy of the aqueous solution of this monomer.
XM was synthesized by acylation of xylitol with methacryloyl chloride. Powdered xylitol, 4-dimethylaminopyridine (DMAP) and hydroquinone were completely dissolved into pyridine. Freshly distillled methacryloyl chloride was then dropped into the solution under dry argon atmosphere. The XM in the mixture was spread out as a single spot (Rf=0.30) on a TLC plate with the chloroform-ethanol elution [70 : 30]. The dropwise method yields 24.2%. The chemical structure of XM was determined by lnfrared (1R) analysis.
The experimental dentin … More primers were prepared as aqueous solutions of the XM at the concentration of 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 and 55%. The bonding efficacy of the primers was evaluated by measuring the polymerization contraction gap in a cylindrical dentin cavity and tensile bond strength to flat dentin surface. The cavity walls as well as the flat dentin surface were cleaned with EDTA, primed with the primer and applied the bonding agent (Clearfil Photo Bond) before cavity filling and application of resin composite on the flat dentin. Marginal gaps between the dentin cavity and the resin composite could not observe with the 30 to 50% XM solution. The tensile bond strengths of the primers were 16.5<plus-minus>4.6 MPa [5%], 12.71<plus-minus>3.4 MPa [15%], 14.9<plus-minus>4.6 MPa [25%], 16.8<plus-minus>5.8 MPa [35%], 20.9<plus-minus>4.1 MPa [45%] and 21.6<plus-minus>5.
The aqueous solution of new synthesized monomer (XM) was effective as a dentin primer at the concentration of 30 to 50%. Before clinical more researching effort to the possible side effect on the skin tissue is required. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report

URL: 

Published: 1994-04-01   Modified: 2016-04-21  

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