| Project/Area Number |
06671954
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
NAKAMOTO Kyoumi Hiroshima Univ., Sch.Dent., Instructor, 歯学部, 助手 (80198259)
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| Co-Investigator(Kenkyū-buntansha) |
ABEKURA Hitoshi Hiroshima Univ., Sch.Dent., Instructor, 歯学部, 助手 (30159454)
TAMAMOTO Mitsuhiro Hiroshima Univ., Dent.Hospital, Assistant, 歯学部・附属病院, 講師 (00136110)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Denture stomatitis / Berberine hydrochloride / Mouthrinse / Candida species / Color stability / Surface roughness / デンチャー プラーク コントロール |
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| Research Abstract |
Candida species can be found in high frequency in denture plaque related t denture stomatitis.It is important to clean oral cavity as well as denture to preve denture stomatitis.
This study investigated the antifungal activity of trial mouthrinses against C.albicans, C.tropicalis, and C.lgabrate and the effects on color stability and surface roughness of dental materials. Trial mouthrinses contain berberine hydrochloride whi is a component of crude drugs, that have strong antifungal activity, and has antifungal activity itself.
Trial mouthrinses showed fungicidal, fungistatic, and postantifungal activity had no effect on color stability and surface roughness of dental materials.
In vitro studies proved that the trial mouthrinses with berberine hydrochlor had antifungal activity and ability to keep the postantifungal activity in oral cavity Hence, use of the mouthrinses seems to be a help in preventing detnure stomatitis
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