| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
In 55 cases of intraoral minor salivary gland tumors (19 pleomorphic adenomas, 19 mucoepidermoid carcinomas, 17 adenoid cystic carcinomas), expression of the oncogene products such as EGF,EGF-R,c-myc, ras p-21 and c-erbB-2 were investigate immunohistochemically. Additionally, in same materials (13 pleomorphic adenomas, 11 mucoepidermoid carcinomas, 7 adenoid cystic carcinomas), the oncogene such as c-myc, ras p-21 and c-erbB-2 were amplified by PCR,and the expression were investigated. In 19 pleomorphic adenomas, the expression of EGF,EFG-R,c-myc product, ras p-21 protein and c-erbB-2 product were 15.8%, 78.9%, 57.9%, 47.4% and 0% respectively. In 19 mucoepidermoid carcinomas, the expression of EGF,EGF-R,c-myc product, ras p-21 protein and c-erbB-2 product were 10.5%, 84.2%, 73.3%, 21.1%, and 0% respectively. In 17 adenoid cystic carcinomas, the expression of EGF,EGF-R,c-myc product, ras p-21 protein and c-erbB-2 product were 5.9%, 0%, 82.4%, 0% and 0% respectively. The expression of oncogene showed a similar tendency. In 36 malignant tumors (19 mucoepidermoid carcinomas, 17 adenoid cystic carcinomas), the expression of EGF-R,c-myc product and ras p-21 protein were related histological typing and graiding, without prognosis correlation.
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