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Analysis of temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.

Research Project

Project/Area Number 06672026
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

NONOYAMA Susumu  Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (80172807)

Co-Investigator(Kenkyū-buntansha) HUJISHIMA Hiroshi  Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (80199314)
MORIMOTO Mitsuaki  Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (90174458)
TUBOTA Kazuo  Tokyo Dental College, Dentistry, Associate Professor, 歯学部, 助教授 (40163878)
KATAGIRI Shigeo  Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (70085752)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsxerostomia / Sjogren's syndrome / evaporation from the oral surface / temperature on the oral surface
Research Abstract

Temperature on the oral surface and saliva evaporation volume from the oral surface were examined.Nineteen Sjogren syndrome patients (SS), twenty-eight Xerostomia patients (X) and thirty-nine normal volunteers (N) were studied. The diagnosis of SS was made on the basis of Japanese criteria. The patients was classified three groups according to the thermal difference and time of the temperature on the oral surface. N-type : thermal difference>2゚C and time<80sec, Ltype : thermal defference>2゚C and time>80sec, M-type : thermal difference<2゚C.70% in N was N-type.35% in SS was M-type and 40% was L-type.30% in X was M-type and 25% was L-type. Saliva evaporation volume from the oral surface was compared with other parameters (labial lip biopsy, salivary gland scintigraphy, stimulated saliva flow). Saliva evaoporation volume from the oral surface (10^<-7>g/m^2・h) was 4.64<plus-minus>1.41 in SS,5.81<plus-minus>1.71 in X and 7.61<plus-minus>1.31 in N (p<0.05). Saliva evaporation volume from the oral surface was 6.16<plus-minus>1.47 in patients with grade 0 or 1 and 4.241.44 in patients with grade 2 or 3 of labial lip biopsy (p<0.05) Saliva evaporation volume from the oral surface was 3.89<plus-minus>1.33 in maximum secretion rate of submandibular gland (MSR) lower patients and 5.781.59 in MSR higher patients (p<0.05). Saliva evaporation volume from the oral surface wasn't related to stimulated saliva flow in this study. These results suggested that these system has a near parameter with labial lip biopsy and resting salivary function, and is thought to be useful for SS or X diagnosis.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 野々山進: "シェ-グレン症候群患者における口内苦痛度とその要因について" 日本口腔診断学会雑誌. 7. 443-444 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野々山進: "ドライアイ・シェ-グレン症候群患者における口唇腺・涙腺の生検所見の比較検討" 日本口腔診断学会雑誌. 43. 862-863 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nonoyama,S: "Clinical significance of autoantibodies in Sjogren's syndrome." Journal of Dental Research. 74. 504- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野々山進: "口腔乾燥症・シェ-グレン症候群患者における口腔粘膜の表面温度、直上湿度の解析 第1報 測定法とその有用性" 歯科学報. 95. 619-620 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 武田宇央: "口腔乾燥症・シェ-グレン症候群患者における口腔粘膜の表面温度、直上湿度の解析 第2報 口唇腺唾液分泌量について" 歯科学報. 95. 1226- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nonoyama,S: "A newly developed system for measuring saliva evaporation." Journal of Dental Research. 75. 313- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野々山進: "Ocular Surfaceの診断と治療B-2検査" メディカル葵出版, 9 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nonoyama,S: "SJOGEREN'S SYDROME-STATE OF THE ART" KUGLER PUBLICATION, 3 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] NONOYAMA,S.etc.: "Oral soreness and related factors in patients with Sjogren's syndrome" Jpn.J.Oral Diag./Oral Med.Vol.7. 443-444 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] NONOYAMA,S.etc.: "Relationship of histopathological findings of labial gland to lacrimal gland in patients with dry-eye and Sjogren's syndrome." J.Jpn.Stonatol.Soc.vol.43. 862-863 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] NONOYAMA,S.etc.: "Clinical significance of autoantibodies in Sjogren's syndrome." J.Dental Research. vol.74. 504 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] NONOYAMA,S.etc.: "Analysis of the temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.Report 1 Method and Evaluation" The Shikwa Gakuho. vol.95. 619-620 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TAKEDA,I.etc.: "Analysis of temperature on the oral surface and saliva evaporation from the oral surface in the patients with xerostomia and Sjogren's syndrome.Report 2 Relation with minor salivary flow rate" The Shikwa Gakuho. vol.95. 1226 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] NONOYAMA,S.etc.: "A newly developed system for measuring saliva evaporation." J.Dental Research. vol.95. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野々山進: "ドライアイ患者における口腔乾燥について" 日本口腔外科学会雑誌. 38. 2225-2226 (1992)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野々山進: "シェ-グレン症候群患者における口内苦痛度とその要因について" 日本口腔診断学会雑誌. 7. 443-444 (1992)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野々山進: "ドライアイ・シェ-グレン症候群患者における口唇腺・涙腺の生検所見の比較検討" 日本口腔科学会雑誌. 43. 862-863 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nonoyama, S: "Clinical significance of autoantibodies in Sjogren' s syndrome." Journal of Dental Research. 74. 504- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野々山進: "口腔乾燥症、シェ-グレン症候群患者における口腔粘膜の表面温度、直上湿度の解析 第1報 測定法とその有用性" 歯科学報. 95. 619-620 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nonoyama, S: "A newly developed system for measuring saliva evaporation." Journal of Dental Research. (発表予定). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野々山進: "Ocular Surfaceの診断と治療 B-2 検査" メディカル葵出版, 9 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nonoyama, S: "SJOGREN' S SYDROME-STATE OF THE ART" KUGLER PUBLICATION, 3 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野々山進: "ドライアイ・シェ-グレン症候群における口腔乾燥アンケート調査について" 歯科学報. 91. 1383-1384 (1991)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野々山進: "ドライアイ・シェ-グレン症候群における口唇腺ならびに涙腺の生検所見について" 歯科学報. 92. 1549-1550 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野々山進: "ドライアイ患者における口腔乾燥について" 日本口腔外科学会雑誌. 38. 2225-2226 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野々山進: "シェ-グレン症候群患者における口内苦痛度とその要因について" 日本口腔診断学会雑誌. 7. 443-444 (1992)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野々山進: "ドライアイ・シェ-グレン症候群患者における口唇腺・涙腺の生検所見の比較検討" 日本口腔科学会雑誌. 43. 862-863 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nonoyama,S.: "Clinical significance of autoantibodies in Sjogren's syndrome." IADR. (発表予定). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野々山進: "Ocular Surfaceの診断と治療 B-2 検査" メディカル葵出版, 9 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nonoyama,S.: "SJOGREN'S SYDROME-STATE OF THE ART" KUGLER PUBLICATION, 3 (1993)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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