| Project/Area Number |
06672026
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
NONOYAMA Susumu Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (80172807)
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| Co-Investigator(Kenkyū-buntansha) |
HUJISHIMA Hiroshi Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (80199314)
MORIMOTO Mitsuaki Tokyo Dental College, Dentistry, Assistant, 歯学部, 助手 (90174458)
TUBOTA Kazuo Tokyo Dental College, Dentistry, Associate Professor, 歯学部, 助教授 (40163878)
KATAGIRI Shigeo Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (70085752)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | xerostomia / Sjogren's syndrome / evaporation from the oral surface / temperature on the oral surface |
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| Research Abstract |
Temperature on the oral surface and saliva evaporation volume from the oral surface were examined.Nineteen Sjogren syndrome patients (SS), twenty-eight Xerostomia patients (X) and thirty-nine normal volunteers (N) were studied. The diagnosis of SS was made on the basis of Japanese criteria. The patients was classified three groups according to the thermal difference and time of the temperature on the oral surface. N-type : thermal difference>2ﾟC and time<80sec, Ltype : thermal defference>2ﾟC and time>80sec, M-type : thermal difference<2ﾟC.70% in N was N-type.35% in SS was M-type and 40% was L-type.30% in X was M-type and 25% was L-type. Saliva evaporation volume from the oral surface was compared with other parameters (labial lip biopsy, salivary gland scintigraphy, stimulated saliva flow). Saliva evaoporation volume from the oral surface (10^<-7>g/m^2・h) was 4.64<plus-minus>1.41 in SS,5.81<plus-minus>1.71 in X and 7.61<plus-minus>1.31 in N (p<0.05). Saliva evaporation volume from the oral surface was 6.16<plus-minus>1.47 in patients with grade 0 or 1 and 4.241.44 in patients with grade 2 or 3 of labial lip biopsy (p<0.05) Saliva evaporation volume from the oral surface was 3.89<plus-minus>1.33 in maximum secretion rate of submandibular gland (MSR) lower patients and 5.781.59 in MSR higher patients (p<0.05). Saliva evaporation volume from the oral surface wasn't related to stimulated saliva flow in this study. These results suggested that these system has a near parameter with labial lip biopsy and resting salivary function, and is thought to be useful for SS or X diagnosis.
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