| Project/Area Number |
06672028
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
AKIMOTO Yoshiaki Nihon University, School of Dentistry at Matsudo, Department of Oral Surgery 2, Associate Professor, 松戸歯学部, 助教授 (10147720)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Akira Nihon University, School of Dentistry at Matsudo, Department of Pharmacology, As, 松戸歯学部, 助教授 (70102564)
MATSUMOTO Hiroko Nihon University, School of Dentistry at Matsudo, Department of Pharmacology, As, 松戸歯学部, 副手 (50221594)
NISHIMURA Hitoshi Nihon University, School of Dentistry at Matsudo, Department of Oral Surgery 2,, 松戸歯学部, 講師 (10198509)
SHIBUTANI Jun Nihon University, School of Dentistry at Matsudo, Department of Oral Surgery 2,, 松戸歯学部, 助手 (20206147)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | methicillin-resistant Staphylococcus aureus / Staphylococcus aureus / incidence / antimicrobial susceptibility / odontogenic and oral infections |
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| Research Abstract |
The present study determined the incidence of isolation and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) isolated from odontogenic infection for a period of 16 years (1980-1995).
There were 2,578 cases of odontogenic infections in the course of the 16 years, in which Staphylococcus aureus (S.aureus) was isolated in 62 cases involving 24 cases of MRSA.The incidence of isolation of S.aureus/all odontogenic infections in each year was low (less than 4%, range 0.6-3.8%) and that of MRSA was less than 3% (range 0-2.3%). MRSA was not found from 1980 to 1987. First MRSA was isolated in 1988. Since then, the number of MRSA infection was gradually increased (1 to 4 cases) from 1988 to 1992 and MRSA was constantly isolated in 4 cases from 1992 to 1995. MRSA was isolated from more than half the cases of S.aureus infection from 1990 to 1995 (50-75%). Most or all strains of MRSA were sensitive to minocycline, lomefloxacin, rifampicin, and vancomycin. Rifampicin showed the lowest MICs (<1 mug/ml).
In conclusion, the incidence of isolation of MRSA from odontogenic infection was low. However, since MRSA was constantly isolated during past 9 years, close attention shuold be paid to MRSA infection in odontogenic infection.
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