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Experimental studies on the effect of maternal environmental factors on the development of cleft lip and/or palate by using fertilized ovum transfer.

Research Project

Project/Area Number 06672032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionAichi-Gakuin University

Principal Investigator

NATSUME Nagato  Aichi-Gakuin Univ., 2nd Dept.of Oral & Maxillofac.Surgery, Assoc.Prof., 歯学部・口腔外科学第二講座, 助教授 (90183532)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Hiroyuki  Aichi-Gakuin Univ., 2nd Dept.of Oral & Maxillofac.Surgery, Assistant Professor, 歯学部・口腔外科学第二講座, 助手 (70261005)
KAWAI Tsuyoshi  Aichi-Gakuin Univ., 2nd Dept.of Oral & Maxillofac.Surgery, Professor, 歯学部・口腔外科学第二講座, 教授 (50064788)
吉田 香  愛知学院大学, 歯学部・口腔外科学第2講座, 助手(非常勤)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
KeywordsCL / CLP / spontaneous CL / P strain mouse / A / J strain mouse / C57BL mouse / Fertilized Ovum Transfer / maternal environmental factor / 受精卵移植マウス
Research Abstract

The cause of spontaneous cleft lip and/or palate (CL/P) of A/J strain mice remains unclear. To clarify whether the genetic factors or maternal environmental factors cotribute to manifestation of this disease, we tried the transplantation of fertilized ovum of CL/P-prone A/J mice into CL/P-resistant C57BL/6 strain mice. The uteri were examined for live and dead fetuses, and resorptions. In the first generation of the transfered A/J mice, neither CL nor CP were observed among 90 live fetuses. In the second generation, CLP alone was found in 5 fesues among 58 live fetuses.
The absence of CP may be suppressed by altered maternal environment of C57BL/6 (foster mother), since CP alone may be more susceptible than CLP to maternal environment. In reverse transplantation of the mice, however, CLP andCP were more remarkably reduced than those of control mice. In particular, no CP developed in the first generation. It is indicated that CLP may be less influenced by maternal environmental factors than CP.It is also predicted that, since CLP was manifested in first and second generation, CLP may be determined by genetic factors retained succesively, rather than by maternal environmental factors.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 角田 典隆, 夏目 長門, 上野 泰宏, 吉田 香, 河合 幹: "口唇口蓋裂に関する実験的研究 第10報:過排卵誘起の胎仔における影響について" 愛知学院大学歯学会誌. 34(2). 283-286 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 上野 泰宏: "受精卵移植後の次世代における口唇、口蓋裂発生について" 愛知学院大学歯学会誌. 35(1). 33-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ueno, Y., Natsume, N., Tsunoda, N., Kawai, T.: "Influence to the Development of Cleft Lip,Palate,or Both by Fertilized Ovum Transfer in A/J Mice." Plastic and Recostructive Surgery. 100(7). 1928-1930 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 角田典隆、夏目長門、上野泰宏、吉田香、河合幹: "口唇口蓋裂に関する実験的研究 第10報:過排卵誘起の胎仔における影響について" 愛知学院大学歯学会誌. 34(2). 283-286 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 上野泰宏: "受精卵移植後の次世代における口唇、口蓋裂発生について" 愛知学院大学歯学会誌. 35(1). 33-38 (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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