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Studies on Behavior and Reduction of Environmental Nitroarenes

Research Project

Project/Area Number 06672138
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionKanazawa University

Principal Investigator

HAYAKAWA Kazuichi  Kanazawa University, Graduate School of Natural Science and Engineering, Associate Professor, 大学院・自然科学研究科, 助教授 (40115267)

Co-Investigator(Kenkyū-buntansha) MATSUDA Haruo  Ishikawa Prefectural Institute of Public Health and Environmental Science, Senio, 専門研究員
MIKAGE Masayuki  Kanazawa University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (50115193)
MIYAZAKI Motoichi  Kanazawa University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (50009164)
松田 春夫  石川県環境保健センター, 専門研究員
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsNitroarene / Dinitropyrene / Nitropyrene / Nitrofluoranthene / Airborne particulate / Diesel-engine vehicle / Direct-acting mutagenicity / Contribution / 大気浮遊粉じん / 自動車排ガス粉塵 / 化学発光 / HPLC / 変異原性
Research Abstract

(1) Each mean concentration of 1,3-dinitropyrene (1,3-DNP), 1,6-DNP,1,8-DNP and 1-nitropyrene (1-NP) in air in downtown Kanazawa were in the levels of fmol m^<-3> and sub pmol m^<33>-pmol m^<-3>, respectively. The concentrations were high in the daytime and low in the midnight and early in the morning. This diurnal variation gave a good correlation to the traffic volume, suggesting automobiles were the main contributors. The concentrations were high in spring and summer and low in autumn and winter. As reasons for this, degradation by sunlight in the former seasons and low atmospheric mixing dephts in the latter seasons were considered.
(2) Concentrations of 1,3-, 1,6-and 1,8-DNPs and 1-NP in air in winter and summer in downtown Kanazawa, Sapporo and Tokyo were determined. Although the mean concentrations in Kanazawa were lower than those in Tokyo and Sapporo, there were similar tendencies as described above. The 1-NP to DNPs ratio in Sapporo was the largest in the three cities, suggest … More ing the largest diesel-engine vehicles to gasoline-engine vehicles ratio.
(3) Concentrations of 1,3-, 1,6-and 1,8-DNPs in diesel Particulate were at the same levels as those in gasoline particulate. However, the concentration of 1-NP in diesel particulate was much higher than that in gasoline particulate. Considering the amount of particulates emitted from diesel-engine much larger than that of gasoline-engine, the contribution of diesel-engine vehicles to the amount of the above compounds in urban air was much larger than that of gasoline-engine vehicles.
(4) In both diurnal and seasonal variation studies, good correlation coefficients were observed between the four concentrations and direct-acting mutagenic activities by the Ames test using three stains, TA98, YG1021 and YG1024. In the three, the YG1024 gave the largest coefficient. The contributions of the four compounds to the activities of air in YG1024 and TA98 strains were about 30% and 10%, respectively. The silica gel column chromatography suggested that the other contributors were less polar. When particulates were separately collected into five fractions of different particulate sizes, both the compounds and the activity were mainly contained in the finest particulate fraction (less than 1.1um) which was most adsorbed in alveoli of the lung. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Kazuichi Hayakawa.: "Determination of 1,3-,1,6-,1,8-Dinitropyrenes and 1-Nitropyrene in Vehicle Exhaust Particulates" Jpn.J.Toxicol Environ.Health. 40. 20-25 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 村橋 毅: "蛍光/化学発光検出高速液体クロマトグラフィーによる大気粉じん中の多環芳香族炭化水素及びそのニトロ誘導体の同時分析" 分析化学. 43. 1017-1019 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 早川和一: "総説:生活環境化学物質を対象とする新規光学検出液体クロマトグラフィーの開発" 薬誌. 114. 669-680 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa.: "Determination of 1,3-,1,6-,and 1,8-Dinitropyrenes and 1-Nitropyrene in Urban Air by HPLC Using Chemiluminescence Detection" Environ.Sci.Technol.29. 928-932 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsuyoshi Murahashi.: "Diurnal Concentrations of 1,3-,1,6-,1,8-Dinitropyrenes,1-Nitropyren and Benzo [a] pyrene in Air in Downtown Kanazawa and the Contribution of Diesel-Engined Vehicles" Jpn.J.Toxicol.Environ.Health. 41. 328-333 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa.: "Distributions of Nitropyrenes and Mutagenicity in Airborne Particulates Collected with an Andersen Sampler" Mutation Res.348. 57-61 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa, Mizuka Butoh, Yukiko Hirabayashi, Motoichi Miyazaki: "Determination of 1,3-, 1,6-, 1,8-Dinitropyrenes and 1-Nitropyrene in Vehicle Exhaust Particulates" Jpn. J.Toxicol. Environ. Health. 40 (1). 20-25 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsuyoshi Murahashi, Kazuichi Hayakawa, Yoko Iwamoto, Motoichi Miyazaki: "Simultaneous Determination of Polycyclic Aromatic Hydrocarbons and Their Nitrated Derivatives in Airborne Particulates by HPLC with Fluorescence/Chemiluminescence Detection" Bunseki Kagaku. 43 (11). 1017-1020 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa: "(Review) Development of New Photometric Detection in Liquid Chromatography for the Determination of Environmental Compounds" Yakugaku Zasshi. 114 (9). 669-680 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa, Tsuyoshi Murahashi, Mizuka Butoh, Motoichi Miyazaki: "Determination 1,3-, 1,6-, and 1,8-Dinitropyrenes and 1-Nitropyrene in Urban Air by High-Performance Liquid Chromatography Using Chemiluminescence Detection" Environ. Sci. Technol.29 (4). 928-932 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsuyoshi Murahashi, Motoichi Miyazaki, Ryuichi Kakizawa, Yoshihisa Yamagishi, Moritsugu Kitamura, Kazuichi Hayakawa: "Diurnal Concentrations of 1,3-, 1,6-, 1,8-Dinitropyrenes, 1-Nitropyrene and Benzo [a]-pyrene in Air in Downtown Kanazawa and the Contribution of Diesel-Engine Vehicles" Jpn. J.Toxicol. Environ. Health. 41 (5). 328-333 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kazuichi Hayakawa, Yoshitatsu Kawaguchi, Tsuyoshi Murahashi, Motoichi Miyazaki: "Distribution of Nitro-pyrenes and Mutagenicity in Airborne Particulates Collected with an Andersen Sampler" Mutation Res.348. 57-61 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] kazuichi Hayakawa: "Determination of 1,3-,1,6-,1,8-Dinitropyrenes and 1-Nitropyrene in Vehicle Exhaust Particulates" Jpn. J. Toxicol Environ. Health. 40. 20-25 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 村橋毅: "蛍光/化学発光検出高速液体クロマトグラフィーによる大気粉じん中の多環芳香族炭化水素及びそのニトロ誘導体の同時分析" 分析化学. 43. 1017-1019 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 早川和一: "総説:生活環境化学物質を対象とする新規光学検出液体クロマトグラフィーの開発" 薬誌. 114. 669-680 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] kazuichi Hayakawa: "Determination of 1,3-,1,6-,and 1,8-Dinitropyrenes and 1-Nitropyrene in Urban Air by HPLC Using Chemiluminescence Detection" Environ. Sci. Technol.29. 928-932 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tsuyoshi Murahashi: "Diurnal Concentrations of 1,3-,1,6-,1,8-Dinitropyrenes,1-Nitropyren and Benzo[a]・pyrene in Air in Downtown Kanazawa and the Contribution of Diesel-Engined Vehicles" Jpn. J. Toxicol. Environ. Health. 41. 328-333 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] kazuichi Hayakawa: "Distributions of Nitropyrenes and Mutagenicity in Airborne Particulates Collected with an Andersen Sampler" Mutation Res.348. 57-61 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 早川和一: "総説:生活環境化学物質を対象とする新規光学検出液体クロマトグラフィーの開発" 薬誌. 114. 669-680 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 村橋 毅: "蛍光/化学発光検出高速液体クロマトグラフィーによる大気粉じん中の多環芳香族炭化水素及びそのニトロ誘導体の同時分析" 分析化学. 43. 1017-1019 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuichi Hayakawa: "Behavior of Mutagenic Nitroarenes in Urban Air" Jpn.J.Toxicol.Environ.Health. 41. P-13 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kazuichi Hayakawa: "Determination of 1,3‐,1,6‐,and 1,8‐Dinitropyrenes and 1‐Nitropyrene in Urban Air by HPLC Using Chemiluminescence Detection" Environ.Sci.Technol.29. (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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