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Nationwide survey of serotypes and atimicrobial susceptibility of Streptococcus pneumoniae between 1994 and 1996

Research Project

Project/Area Number 06672305
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionJUNTENDO UNIVERSITY

Principal Investigator

IGARI Jun  Juntendo University School of Medicine, Assistant, 医学部, 教授 (20053100)

Co-Investigator(Kenkyū-buntansha) 三宅 一徳  順天堂大学, 医学部, 助手 (30190747)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
KeywordsStreptococcus pneumoniae / Serotype / Antimicrobial susceptibility / Penicillin-binding-proteins / PBP2X / PBP2B / Penicillin-resistant strain
Research Abstract

This study was conducted to investigate antimicrobial susceptibilities and serotypes of clinical isolates of S.pneumoniae in aeveral medical centers throughout Japan from 1994 to 1996.
Penicillin-resistant S.pneumoniae was isolated in 30 to 50% of the total isolates and the resistant isolates widely distributed throughout Japan.
The most common serotypes were 3,6,19 and 23 in the total isolates as well as in those of Penicillin-resistant S.pneumoniae.
More than 50% of the isolates showed resistance to tetracyclines (TC,MINO), macrolides (EM,CAM) and clindamycin. There was no resistant isolate to vancomycin and the isolates having high resistant to quinolones were small in number. The strong antibacterial activity to the isolates was observed carbapenems (IPM,PAPM) in beta-lactam antibiotics and CDTR and CFPN in oral cephems.
Concerning a screening test by a disk diffusion method for detecting cefotaxime-resistant strains of S.pneumoniae, cefaclor disk method was superior to a cefotaxime disk method which was apt to miss a resistant strain.
We investigated alteration of penicillin-binding proteins genes (PBP2B and PBP2X genes) of the resistant strains of S.pneumoniae.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] T Oguri, S Misawa, J Igari: "In vitro antimicrobial activity of oral beta-lactam antibiotics against Streptococcus pneumoniae from clinical specimens." Jpn J Chemother. 43 (5). 531-537 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary

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Published: 1994-04-01   Modified: 2016-04-21  

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