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Homosynaptic and heterosynaptic modulation of the information processing in the mammalian parasympathetic ganglia.

Research Project

Project/Area Number 06680818
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 神経・脳内生理学
Research InstitutionKurume University

Principal Investigator

NISHIMURA Toshihiko  Kurume Univ.Sch.Med., Associate Professor, 医学部, 講師 (30172696)

Co-Investigator(Kenkyū-buntansha) 時政 孝行  医学部, 助教授 (50155511)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsHomosynaptic Facilitation / Heterosynaptic Depression / Parasympathetic Ganglion / Oscillator / High Pass Filter / Low Cut Filter / 膜電位振動 / 自発性発火 / 神経ネットワーク / 残余カルシウム / 副交感神経細胞 / アセチルコリン / アデノシン三リン酸 / 同シナプス性促進通 / ハイパス・フィルター
Research Abstract

Two types of homosynaptic facilitation [1 & 2 (1)] and one type of heterosynaptic depression [2 (2)] were determined in mammalian pelvic parasympathetic ganglia in vitro, utilizing intracellular recording techniques.
1. rabbit vesical pelvic ganglia that innervate the urinary bladder
Most of synapses in the ganglia function as a high pass filter ; only when the action potentials of preganglionic neurons occur at high frequency such as 10 Hz, the nicotinic fast EPSP can evoke the orthodromic action potentials. Mechanisms of the filter involve the purinergic low-cut-filter and the frequency dependent increase of transmitter release. The former consists of endogenous ATP and presynaptic inhibitory P_2 receptors. The later might be explained by the "residual calcium" hypothesis.
2. feline colonic ganglia that innervate colonic effector structures
(1) effect of pelvic nerve stimulation
Repetitive stimulation (10 Hz, 30 sec) of pelvic nerve (PN) augmented a spontaneous oscillation of membrane potential termed a depolarizing membrane oscillation (DMO) of feline parasympathetic neurons. These augmented DMO triggered an action potential, converting a silent neuron to a spontaneously firing neuron. Effects of PN-stimulation were antagonized by atropine and mimicked by muscarine.
(2) effect of hypogastric nerve stimulation
Contrary repetitive stimulationof hypogastric nerve (HGN) often depressed the DMO,converting the spontaneously firing neuron to the silent neuron. Effects of HGN-stimulation were partially antagonized by yohimbine and mimicked by norepinephrine.
These results provide a new type of autoinhibition at nicotinic synapses and interaction between sympathetic and parasympathetic division in the parasympathetic ganglia.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] Nishimura,T.: "Effects of adenosine 5'-triphosphate on neurons in rabbit parasympathetic ganglia." Can. J. Physiol. Pharmacol.72 Supp1. 1. 502 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Magnesium modulates spontaneous oscillation of membrane current in mammalian neurones." Jpn. J. Physiol.44 Suppl. 1. 147 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Adenosine 5'-triphosphate induces membrane depolarization through P_<2Y> receptors in rabbit parasympathetic neurons." Kurume Med. J.41. 161-164 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Endogenous ATP modulates nicotinic transmission through presynaptic P_2 receptors in rabbit parasympathetic ganglia." Neurosci. Res.Suppl. 19. 31 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Role of presynaptic P_2 and A_1 receptors on the nicotinic transmission in rabbit parasympathetic ganglia." Jpn. J. Pharmacol.67 Suppl. 1. 217 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Activation of calcium-dependent chloride channels causes post-tetanic depolarization in rabbit parasympathetic neurons." J. Auton. Nerv. Syst.51. 213-222 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 西村俊彦: "ウサギ副交感神経細胞に於けるエンドセリン受容体の情報伝達系" 日本生理誌. 57. 158 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akasu,T.: "Synaptic transmission and function of parasympathetic ganglia." Prog. Neurobiol.45. 459-522 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Galanin causes presynaptic inhibition of cholinergic transmission in rabbit parasympathetic ganglia." Kurume Med. J.42. 45-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Mechanism of high pass filter in nicotinic transmission of rabbit parasympathetic ganglia." 4th IBRO Abstr.24 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Purinergic low-cut filter mechanism of the synaptic transmission in rabbit parasympathetic ganglia." Neuropharmacology III Abstr.22 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura,T.: "Mechanism of frequency dependent facilitation of nicotinic transmission in rabbit parasympathetic ganglia." Soc. Neurosci. Abstr.21. 1088 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Effects of adenosine 5'-triphosphate on neurons in rabbit parasympathetic ganglia." Can.J.Physiol.Pharmacol.72 (Suppl.1). 502 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Magnesium modulates spontaneous oscillation of membrane current in mammalian neurones." Jpn.J.Physiol.44 (Suppl.1). 147 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Adenosine 5'-triphosphate induces membrane depolarization through P2Y receptors in rabbit parasympathetic neurons." Kurume Med.J.41. 161-164 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Endogenous ATP modulates nicotinic transmission through presynaptic P2 receptors in rabbit parasympathetic ganglia." Neurosci.Res.Suppl.19. 31 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Role of presynaptic P2 and Al receptors on the nicotinic transmission in rabbit parasympathetic ganglia." Jpn.J.Pharmacol.67 (Suppl.1). 217 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Activation of calciumdependent chloride channels causes post-tetanic depolarization in rabbit parasympathetic neurons." J.Auton.Nerv.Syst.51. 213-222 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Akasu, T.: "Synaptic transmission and function of parasympathetic ganglia." Prog.Neurobiol.45. 459-522 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Galanin causes presynaptic inhibition of cholinergic transmission in rabbit parasympathetic ganglia." Kurume Med.J.42. 45-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Mechanism of high pass filter in nicotinic transmission of rabbit parasympathetic ganglia." 4th IBRO Abstr.24. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Purinergic low-cut filter mechanism of the synaptic transmission in rabbit parasympathetic ganglia." Neuropharmacology III Abstr.22. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Mechanism of frequency dependent facilitation of nicotinic transmission in rabbit parasympathetic ganglia." Soc.Neurosci.Abstr.21. 1088 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Mechanism of high pass filter in cholinergic synapse of rabbit vesical parasympathetic ganglia (VPG)." Jpn.J.Physiol.45 (Suppl.1). 133 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Function of purinergic system on nicotinic transmission in rabbit parasympathetic ganglia." Jpn.J.Physiol.45 (Suppl.2). 160 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nishimura, T.: "Role of presynaptic P_2 and A_1 receptors on the nocotinic transmission in rabbit parasympathetic ganglia." Jpn. J. Pharmacol.67 Suppl. 1. 217- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Activation of calcium-dependent chloride channels causes post-tetanic depolarization in rabbit parasvmpathetic neurons." J. Auton. Nerv. Syst.51. 213-222 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 西村俊彦: "ウサギ副交感神経細胞に於けるエンドセリン受容体の情報伝達系." 日本生理誌. 57. 158- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akasu, T.: "Synaptic transmission and function of parasympathetic ganglia." Prog. Neurobiol.45. 459-522 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Galanin causes presynaptic inhibition of cholinergic transmission in rabbit parasympathetic ganglia." Kurume Med. J.42. 45-48 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Mechanism of high pass filter in nicotinic transmission of rabbit parasympathetic ganglia." 4th IBRO Abstr.24- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Purinergic low-cut filter mechanism of the synaptic transmission in rabbit parasympathetic ganglia." Neuropharmacology III Abstr.22- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Mechanism of frequency dependent facilitation of nicotinic transmission in rabbit parasympathetic ganglia." Soc. Neurosci. Abstr.21. 1088- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Mechanism of high pass filter in cholinergic synapse of rabbit vesical parasympathetic ganglia (VPG)." Jpn. J. Physiol.45 Suppl. 1. 133- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura, T.: "Function of purinergic system on nicotinic transmission in rabbit parasympathetic ganglia." Jpn. J. Physiol.45 Suppl. 2 (in press). (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 西村俊彦: "副交感神経節内の情報処理に対する交換・副交換神経性制御." 日本生理誌. 58. 30- (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishimura,T.: "Effects of adenosine 5′-triphosphate on neurons in rabbit parasympathetic gnglia." Can. J.Physicol.Pharmacol. 72 Suppl.1. 502- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Magnesium modulates spontaneous oscillation of membrane curreut in mammalian neurones." Jpn.J.Physiol.44 Suppl.1. 147- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Adenosine 5′-triphosphate indudces membrane depolarization through P_<2Y> receptors in rabbit parasympathetic neurons." Kurume Med.J.41. 161-164 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Endogenous ATP modulates nicotinic transmission through presynaptic P_2 receptoras in rabbit parasympathetic ganglia." Neurosci.Res.Suppl.19. 31- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Activation of calcium-dependent chloride channels causes post-tetanic depolarization in rabbit parasympathetic neurons." J.Auton.Nerv.Syst.in press. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Akasu,T.: "Synaptic transmission and function of parasympathetic ganglia." Progr.Neurobiol.in press. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Role of presynaptic P_2and A_1 receptors on the nicotinic transmission in rabbit,parasympathetic ganglia." Jpn.J.Pharmacol.Suppl.in press. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 西村俊彦: "ウサギ副交感神経細胞に於けるエンドセリン受容体の情報伝達系." 日本生理誌. 57in press. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Nishimura,T.: "Galanin causes presynaptic inhibition of cholinergic transmission inrabbit parasympathetic ganglia." Kurume Med.J.42in press. (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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