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Effects of lighting condition to the behavioral and drug sensitive rhythms in the rat

Research Project

Project/Area Number 06680825
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionGunma University School of Medicine

Principal Investigator

SHINODA Motoo  School of Medicine, Gunma University, 医学部, 助手 (70084605)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Keywordslighting condition / intensity of illumination / spontaneous motor activity / rats / diurnal rhythm / sensitivity / pentobarbital / cocaine / 飲水行動
Research Abstract

Male Wistar-Imamichi (W-I) and BN rats were placed under the various intensity of illumination (10,100 and 1000 1ux). Lighting cycle was LD=12 : 12 (6 : 00 lights on). Present study leads the following results.
(1) Ambulatory activity of W-I was affected by the intensity of illumination. However, this effect was rather small in BN rats. It was observed to higher ambulatory activity during lighting period in the group of W-I under the 10 lux. Except this phenomenon, there was no difference in the daily behavioral rhythm pattern of ambulatory activity under the various intensity of illumination in the both rat strain.
(2) In pentobarbital sodium 50mg/kg i.p.injection to W-I and BN at 9 : 00 and 18 : 00, there was no difference in the anesthetic effect among the three groups under the various intensity of illumination. However, anesthetic effect lasted longer in the rats of 9 : 00 PB injiection than that of 18 : 00 injection
(3) In cocaine 10mg/kg s.c.injection to the both strain at 9 : 00, the strongest acute effect was observed under the 10 lux.
(4) In W-I strain, acute effect of cocaine injection at 18 : 00 continued longer than that at 9 : 00. In W-I,the strongest acute effect was observed under the 10 lux. However, acute effect was least under the 10 lux in BN.
(5) Biochemical analysis was done with blood taken at 9,12,18,21 and 24 : 00 under the various intensity of illumination. There were some differences in the level of total protein, glucose, GTP et al due to the different intensity of illumination.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Y. Iijima, T. Asami, M. Shinoda, et al.: "Changes in the Sensitivity to Methamphetamine Induced by Saline Treatment in the Measurement and Breeding Cages: Evaluation by Ambulation in Mice" Jap. J. Psych. Neurol.48. 710-711 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iijima, T. Asami, M. Shinoda, et al.: "Evaluation of the rebound phenomenon (sub-acute behavioral suppression) induced by cocaine by means of wheel-running and drinking in mice" Neuropsychopharmacology. 10 (3s/part2). 125S (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 飯島幸生、篠田元扶、浅見隆康、他: "マウスの車回しおよび飲水行動の日周リズムからみたコカインの急性効果および反跳現象" 日本神経精神薬理学雑誌. 14. 548- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iijima, M. Shinoda, H. Kuribara, et al.: "Evaluation of acute and sub-acute effects of cocaine by means of circadian variation in wheel-running and drinking in mice" Jpn. J. Psychopharmacol.15. 315-321 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H. Kuribara, M. Shinoda and Y. Uchihashi: "Delayed effects of ethanol, caffeine and nicotine assessed by wheel-running and drinking in mice" J. Toxicol. Sci.20. 595-602 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Shinoda: "Animal experiment and circadian rhythms (in Japanese)" Lab.Anim.Techn.Sci.6 (3). 49-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Shinoda: "Behavioral function test -circadian rhythm of behavior- (in Japanese)" Seitaino kagaku. 45 (5). 512-513 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iijima, T.Asami, M.Shinoda, H.Kuribara, I.Ida, T.Higuchi, and Machiyama, Y.: "Changes in the Sensitivity to Methamphetamine Induced by Saline Treatment in the Measurement and Breeding Cages : Evaluation by Ambulation in Mice" Jap.J.Psych.Neurol. 48 (3). 710-711 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iijima, T.Asami, M.Shinoda, Y.Uchihashi, H.Kurihara, I.Ida, T.Higuchi, and Y.Machiyama: "Evaluation of the rebound phenomenon (sub-acute behavioral suppression) induced by cocaine by means of wheel-running and drinking in mice" Neuropsychopharma-cology. 10 (3s/part2). 125S (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iijima, M.Shinoda, T.Asami, H.Kurihara, I.IdaT.Higuchi, Y.Machiyama and Y.Uchihashi: "Evaluation of the rebound phenomenon induced by cocaine by means of wheel-running and drinking in mice (in Japanese)" Jap.J.Neuropharmacol. 14 (6). 548 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Shinoda: "Biological rhythm and animal experimentation Mechanisms of biological rhythm (in Japanese)" JSLA Bulletine. 57. 1-3 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Iijima, M.Shinoda, H.Kuribara, T.Asami and Y.Uchihashi: "Evaluation of acute and sub-acute effects of cocaine by means of circadian variation in wheel-running and drinking in mice" Jpn.J.Psychopharmacol.15. 315-321 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Kuribara, M.Shinoda and Y.Uchihashi: "Delayd effects ethanol, caffeine and nicotine assessed by wheel-running and drinking in mice" J.Toxicol.Sci.20. 595-602 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Iijima, T. Asami, M. Shinoda, et al: "Changes in the Sensitivity to Methamphetamine Induced by Saline Treatment in the Measurement and Breeding Cages: Evaluation by Ambulation in Mice" Jap. J. Psych. Neurol.48. 710-711 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Iijima, T. Asami, M. Shinoda, et al: "Evaluation of the rebound phenomenon (sub-acute behavioral suppression) induced by cocaine by means of wheel-running and drinking in mice" Neuropsychopharmacology. 10 (3s/parts2). 125S (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 飯島幸生、篠田元扶、浅見隆康 他: "マウスの車回しおよび飲水行動の日周リズムからみたコカインの急性効果および反跳現象" 日本神経精神薬理学雑誌. 14. 548- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Iijima, M. Shinoda, H. Kuribara, et al: "Evaluation of acute and sub-acute effects of cocaine by means of circadian variation in wheel-running and drinking in mice" Jpn. J. Psychopharmacol.15. 315-321 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H. Kuribara, M. Shinoda and Y. Uchihashi: "Delayed effects of ethanol, caffeine and nicotine assessed by wheel-running and drinking in mice" J. Toxicol. Sci.20. 595-602 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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