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The Effect of Environmental and Social Stress on Testicular Function in male Japanese monkeys.

Research Project

Project/Area Number 06680830
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIMIZU Keiko  Primate Research Institute, Kyoto University, Technician, 霊長類研究所, 教務職員 (90135616)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsJapanese monkey / Male / Stress / Testosterone / Cortisol / Testis
Research Abstract

Five sexually mature, male Japanese monkeys (Macaca fuscata fuscata), at least 8yrs old were used. They were housed in an each outdoor social group cage with some females at the Primate Research Institute, Kyoto University, Japan. After two weeks of blood sampling, they were isolated from a social group to an indoor air-conditioned individual cage in the mid breeding season. After two weeks these males were returned to their home cages. Blood samples were obtained following both the removal and the return two weeks later. Plasma concentrations of luteinizing hormone (LH), testosterone, cortisol, prolactin, and inhibin were determined by specific radioimmunoassays. Plasma concentrations of testosterone were significantly increased after the isolation, whereas cortisol levels were decreased. Following after return to their home cage, these changes were recovered. The absence of a stress response to separation in adult males is in contrast to the presence of a stress response observed in infants, juveniles, and adult females and possibly is due to the differences of environmental temperature.
In the next bleeding season, same monkeys were isolated from a social group to an outdoor individual cage. After two weeks isolation, they were returned to their home cages. Blood samples were obtained in the same manner. Plasma testosterone were significantly increased immediately after both isolation and return, but decreased within the isolation period. In contrast with the previous study, plasma cortisol were elevated immediately after both isolation and return. Plasma LH,prolactin, and inhibin were not changed before and after the isolation. These results showed that the isolation was influenced these males as a stressor. Furthermore, the return to the social group did induce a psychosocial stress response in the males and the degree of the stress.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 清水慶子: "飼育環境とオスニホンザルの内分泌動態" 霊長類研究. 11. 290- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 清水慶子: "隔離がオスニホンザルの生殖機能に及ぼす影響" 第42回日本実験動物学会総会講演要旨集. 115- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Keiko Shimizu: "Endocrine response to removal from and return to a group cage in adult male Japanese monkeys." Journal of Repriduction and Fertility.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Keiko Shimizu: "Endocrine response to removal from and return to a group cage in adult male Japanese monkeys." Primate Research. 11. 290 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Keiko Shimizu: "The Effects of Isolation on Reproductive Function in Male Japanese macaques." Abstract of The 42th Congress of Japan Experimental Animals. 115 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Keiko Shimizu: "Endocrine response to removal from and return to a group cage in adult male Japanese monkeys." Journal of Reproduction and Fertility. (in preparation).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published: 1994-04-01   Modified: 2016-04-21  

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