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Significance of detection of drug-resistant organisms in laboratory animal colonies

Research Project

Project/Area Number 06680837
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionKeio University School of Medicine

Principal Investigator

MAEJIMA Kazuyoshi  Keio Univ.Sch.Med./Prof., 医学部, 教授 (70051464)

Co-Investigator(Kenkyū-buntansha) SHIMODA Kouji  Keio Univ.Sch.Med./Res.Associate, 医学部, 助手 (00129470)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsDrug-resistant / Laboratory animals / Intestinal flora / E.coli / Streptococcus / Staphylococcus / MRSA / 院内感染モデル
Research Abstract

According to our previous data obtained in 1960s and 1980s in Japan, drug-resistant organisms were temporarily isolated from the laboratory animals given antibiotics for control of infectious diseases, and were hardly detected in the animals untreated with antibiotics. These observations were apparently different from the findings that various types of drug-resistant organisms were widely contaminated in human beings and domestic animals. Based on these data, we have a plan to establish an animal model for investigation on the distribution of drug resistant organisms in human and animal wards.
At first, the present examination was made to confirm our previous data that drug-resistant organisms were hardly isolated from the laboratory animals. Isolation of E.coli, Streptococcus faecalis and Staphylococcus aureus was made on the fresh feces of mice, rats, guinea-pigs and rabbits housed in 5 commercial breeders and 5 animal experimentation facilities in Kyushu aereas. Using a routine techniques, the isolates were examined for drug-resistance to 9 antibiotics including ampicillin, tetracyclin, streptomycin, kanamycin, gentamycin and others.
All the isolates were resistant to various antibiotics with different paterns. Drug-resistant organisms were also isolated from laboratory animals though given no antibiotics. The present results indicated that drug-resistant organisms were widely disturbed in the laboratory animals same as human beings and domestic animals. And now, laboratory animals seems to be not an adequate model for investigation on the distribution of drug-resistant oragnaims in the wards.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 前島 一淑: "実験動物生態学1.生態学的アプローチ" アニテックス. 6. 153-158 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 池島 宏子: "Spermatocyte-specific transcription by calmodulin gene II promotor in transgenic mice." Mol.Cel.Endocrinol.99. 49-53 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 下田 耕治: "Spatial and temporal regulation of rat calmodulin gene III directed by a 877-Base promotor and 103-base leader segment in the mature and embyonal central nervous system of transgenic mice." Mol.Brain Res.31. 61-70 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 前島 一淑: "実験動物生態学5.サル類の社会的幸福" アニテックス. 7. 41-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 潘 甜美: "Deoderization of laboratory animal faeilities by ozone." Exp.Anim.44. 255-259 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 鈴木 照雄: "Hemotological and serum biochemical values in pregnant and postpatritum females of squirrel monkey." Exp.Anim.45. 39-43 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 信永 利馬 他: "バイオメディカルリサーチマニュアルV実験外科学" 養賢堂, 259 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 笠井 憲雪 他: "バイオメディカルリサーチマニュアルVI疾患モデル動物" 養賢堂, 212 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maejima, Kazuyoshi & Shimoda, Kouji: "Laboratory Animal Ecology 1. An Ecological approach." Anitex. 6. 153-158 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maejima, Kazuyoshi & Shimoda, Kouji: "Laboratory Animal Ecology 2.Influences of breeding enviroment (1)" Anitex.6. 223-229 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maejima, Kazuyoshi & Shimoda, Kouji: "Laboratory Animal Ecology 3.Influences of breeding enviroment (2)" Anitex.6. 303-309 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maejima, Kazuyoshi & Shimoda, Kouji: "Laboratory Animal Ecology 4.Influences of room-mate and cage-mate animals." Anitex. 6. 352-367 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ikeshima, Hiroko et al.: "Spermatocyte-specific transcription by calmodulin gene II promotor in transgenic mice." Mol.Cel.Endocrinol.99. 49-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Maejima, Kazuyoshi & Shimoda, Kouji: "Laboratory Animal Ecology 5.Social and psycological influences" Anitex.7. 41-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Simoda, Kouji et al.: "Spetial and temporal regulation of the rat calmodulin gene III directed by a 877-base promotor and 103-base leader segment in the mature and embryonal central nervous system of transgenic mice." Mol.Brain, Res.31. 61-70 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Pan, Tien Mei et al.: "Deoderization of laboratory animal facilities by ozone." Exp.Anim.44. 255-259 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suzuki, Teruo et al.: "Hematological and serum biochemical values in pregnant and postpatritm females of squirrel monkey." Exp.Anim.45. 39-43 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nobunaga, Toshima et al.: Biomedical Research Manual V-Experimental Surgery, edited by K.Maejima & H.Nagasawa. Yoken-Do, Tokyo, 259 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kasai, Noriyuki et al.: Biomedical Research Manual VI-Animal Models, edited by K.Maejima & H.Nagasawa. Yoken-Do, Tokyo, 212 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Asano, Toshihiko et al.: Yoken-Do, Tokyo1995. Biomedical Research Manual VII-Special Experimental Techniques, edited by K.Maejima & H.Nagasawa, 205 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 下田耕治: "Special and temporal regulation of the rat calmodulin gene III directed by a 877-base promotor and 103-base leader segment in transgenic mice." Molecular Brain Research. 31. 61-70 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 潘 甜 美: "Deodrization of laboratory animal failities by ozone." Experimental Animals. 44. 255-259 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 蔡 毅: "中国四逆散,加味消遥散,柴胡琉肝散とその原未煎液中の微量元素" 製剤と機械. 194. 10-12 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鈴木照雄: "Homatological and serum biochemical values in pregnent and postpatrtum females of sguirrel monkey." Experimental Animals. 45. 39-43 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 信永利馬: "動物実験法5-実験外科手技" (株)養賢堂, 252 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 浅野敏彦: "動物実験法7-特殊な実験処置" (株)養賢堂, 205 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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