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EFFECTS OF HIGH PRESSURE PULSES ON CELLS AND THEIR FUNCTIONAL ORGANSIMS

Research Project

Project/Area Number 06680856
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKYOTO UNIVERSITY OF EDUCATION

Principal Investigator

TESHIMA Koji  KYOTO UNIVERSITY OF EDUCATION,PROFESSOR, 教育学部, 教授 (90026104)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Tomohide  KYOTO UNIVERSITY OF EDUCATION,ASSOCIATE PROFESSOR, 教育学部, 助教授 (10117905)
OSHIMA Toshihisa  KYOTO UNIVERSITY OF EDUCATION,PROFESSOR, 教育学部, 教授 (10093345)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHIGH PRESSURE PULSE / SHOCK WAVE / YEAST CELL / NORMAL CELL / CANCER CELL / 細胞 / 細胞技能成分 / 腫瘍細胞 / 生体細胞の衝撃波への耐性 / 細胞機能成分 / ハツカネズミ癌細胞
Research Abstract

It is not so often that living cells are exposed on high pressure pulses, but studies on influecnes of shock waves on organs, tissues and cells have been attracted as developing extracorporeal shock wave lithotripsy. As a microscopic and basic study we examined shock wave effects on microorganisms and mammalian cells and obtained following results.
1) We have constructed a new facility, which can produce high pressure pulses repeatedly in a few seconds interval. The performance of the facility, which was examined numerially and experimentally shows that it is suitable for the present purpose.
2) Shock waves are bitted against yeast cells, which have relatively hard cell wall and number of collonies made by these yeast cells and amount of the leaked enzyme from the destructed cells were examined. The result shows that the shock exposed cells made less number of collonies without destruction of the cell walls, which suggests that some microogans inside the cell loose its function through the shock exposure before the cell wall is mechanically destructed.
3) Effects of shock waves on normal and mlignant mammalian cells were examined. Two types of cells were tested : adherent and non-adherent cells. The result indicates that resistant nature of a cell to the shock wave varies on the cell type with relation to adherent nature of the cells other than malignancy.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 大島敏久: "細胞および細胞機能成分にたいする衝撃波の影響" 高圧バイオサイエンス. 354-359 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 手島光司: "Biomechanical effects of shock waves on Eschenchia coli and λphage DNA" Shock Waves. 4. 293-297 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 細川友秀: "Destructions of mouselymphoma cells with high pressure pulses generated by a diaphragmless shock tube" Shock Waves. 5. 19-23 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 手島光司: "衝撃波ハンドブック高山和喜編" シュプリンガー・フェアラーク東京, 916-921 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Koji TESHIMA: "BIOMECHANICAL EFFECTS OF SHOCK WAVES ON ESCHERICHIA COLI AND lambda PHAGE DNA" SHOCK WAVES. 4. 293-297 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tomohide HOSOKAWA: "DESTRUCTION OF MOUSE LYMPHOMA CELLS WITH HIGH PRESSURE PULSES GENERATED BY A DIAPHRAGMLESS SHOCK TUBE" SHOCK WAVES. 5. 19-23 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.TESHIMA: "High-frequent generation of hrel pressone pulses using a diaphragmless shock tuqe" Shock Waves B Marseille. Vol. 1. 221-226 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.TESHIMA,T.Ohshima,S.Tanaka,T.Nagai: "Biomechanical effats of shock waves on Escherichia Coli and T prage DNA" Shock Waves. 4. 293-297 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Hosokawa,M.Yamamoto,K.TESHIMA: "Destruction of mouse lymphoma cells with high pressone pulses genereited by a diaphragmless shock tuqe" Shock Waves. 5. 19-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 手島光司,大島敏久: "衝撃波ハンドブック" シュプリンガー東京,高山和喜編, 1256 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.TESHIMA: "High-ferquent generation of high pressure pulses using a diaphragmless shock tube" Proceedingx.19^<th> International Spmposium on Shok Waves. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.TESHIMA: "Biomechanical effects of shock waves on Escherichia coli and λpnage DNA" Shock Waves. 5(in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Hosokawa: "Destructing of mouse lymphoma cells with high pressure pulses generated by a diphrogmless shock tube" Shock Waves. 5(in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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