| Project/Area Number |
06680859
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
MATSUNO Takashi Kitasato University, School of Medicine Associate Professor, 医学部, 助教授 (80104537)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOISHI Masumi Science University of Tokyo, Faculty of Industrial Science and Technology Profes, 基礎工学部, 教授 (70084423)
SAKURAI Kiyoko Kitasato University, School of Allied Health Sciences Professor, 医療衛生学部, 教授 (60050506)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | Hydroxyapatite / Zirconia / Composite Particle / Sintered Body / Fracture Toughness |
|---|
| Research Abstract |
Several studies have been made using powder mixture of hydroxyapatite (HAP) and partially stabilized zirconia (PSZ) so far to develop an artificial bone material with affinity to bone tissue and exhibiting high mechanical strength and fracture toughness, but with less satisfactory results. In this study surface coating of relatively large-sized spherical fine HAP particles (Dm=9.32mum) with small-sized fine PSZ particles (Dm=0.12mum) by the dry impact blending method conducted. The spherical fine HAP particles were mixed with fine PSZ particles using an NHS-0 Type Hybridization System (Nara Machinery Co.). The surface of the spherical fine HAP particles were completely coated with the fine PSZ paricles. The fracture toughness of the sintered body consisting of 100% HAP was 1.1MPam^<0.5>, while those with the HAP/PSZ weight ratios of 10/2 and 10/5, and 10/10 are 1.8 and 2.8 MPam^<0.5>, respectively. Fracture toughness values of 2.8 MPam^<0.5> is close to the 3.0 MPam^<0.5> required for the artificial bone. By electron microscopic observation, it was revealed that fine HAP particles directly connected to each other are seldom observed. The sintered body of the composite fine particles comprises a three-dimensional, continuously reticulate phase of PSZ in which spherical fine HAP particles are scattered. It could be understand from this observation fracture toughness of PSZ still remains in the sintered body of the composite fine particles. The result of the X-ray diffractometry indicates that the sintered bodies with the HAP/PSZ ratios of 10/2,10/5 and 10/10 consist of HAP and PSZ alone, showing that HAP is not transformed to tricalcium phosphate.
|
