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Computational fluiddynamical analysis of correlations between blood flow and LDL at the vascular location where atherosclerosis occurs preferentially

Research Project

Project/Area Number 06680868
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKawasaki College of Allied Health Professions

Principal Investigator

KAGIYAMA Mitsuyasu  Kawasaki College of Allied Health Professions, Department of Medical Electronics, Lecturer, 医用電子技術科, 講師 (60204335)

Co-Investigator(Kenkyū-buntansha) KAJITA Fumihiko  Kawasaki College of Allied Health Professions, Department of Medical Electronics, 医用電子技術科, 教授 (70029114)
MOCHIZUKI Seiichi  Kawasaki College of Allied Health Professions, Department of Medical Electronics, 医用電子技術科, 講師 (60259596)
GOTO Masami  Kawasaki College of Allied Healt Professions, Department of Medical Electronics,, 医用電子技術科, 助教授 (50148699)
MATSUMOTO Takeshi  Kawasaki College of Allied Health Professions, Department of Medical Electronics, 医用電子技術科, 講師 (30249560)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsNumerical Fluiddynamics / Lattice Gas Automaton / Lattice Boltzman Equation / Blood Flow / 計算流体力学 / 格子気体 / 格子気体法 / 格子ボルツマン方程式
Research Abstract

The final goal of this study is to analyze the effects of the hemodynamics at the vascular locations where atherosclerosis occurs preferentially and mechanical properties of endthelial cells on and LDL through vessel walls using computational fluid mechanics. In the first year, a computer program simulating a blood flow by a lattice gas automaton (LGA) method was developed. In a LGA method, both space and time are descrete and particles move along links on a regular lattice and collide each other on each lattice site according to some properly desinged rules and conservation lows. Although the LGA method seems to offer a simple and efficient tool for simulating blood flows, it was difficult to achieve high accuracy with LGA because of its statistical noise according to the particle nature. In the second year we applied the lattice Boltzman equation (LBE) method for simulating blood flows. One advantage of the LBE method is the absence of the noise as described above. A computer program to solve numerically the LBE equation is developed and tested by applyng to two dimensional flow field Furthermore, a numerical analysis of blood flow at the aorto-renal bifurcations was carried out using computational fluiddynamics code alpha-flow based on finite difference methods. Numerical results were agreed with in-vivo data measured by 20Mhz ultrasound pulsed Doppler velocimeter.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 鍵山光庸、他: "動脈硬化頻発部位の血流動態の計算流体力学的解析" 医療情報学連合大会論文集. 15. 267-268 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsumoto, T et al: "Evaluation of Spatial Control Unit for Regional Myocardial Blood Flow by a Molecular Flow Tracer" The 2nd World Congress of Biomechanics. Abstract. 1. 34-34 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mochizuki, S et al: "Effect of intramyocardial slosh phnomenon on the endothelial cell form of the coronary artery" World congress on medical physics and biomedical engineering. Proceedings. 201-201 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Goto, M et al: "Observation of the Thebesian Vein and its Outflow in the Beating Canine Heart" J. Cardiovascular Diagnosis and Procedures. 12. 117-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mitsuyasu KAGIYA: "Analysis of the characteristics of blood flow patterns in arteries at the aorto-renal bifurcations using computational fluiddynamics (in Japanese)" 15th JCMI. 267 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takeshi MATSUMOTO: "Evaluation of spatial control unit for regional myocardial blood flow by a molecular flow tracer" The 2nd world congress of biomechanics. 1. 34 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Seiichi MOCHIZUKI: "Effect of intramyocardial slosh phenomenon on the endthelial cell form of the coronary" World congress on medical phisics and biomedical engineering. 201 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Masami GOTO: "Observation of the thebesian vein and its outflow in the beating heart" J.Cardiovascular Diagnosis and Procedures. 12. 117 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 鍵山光庸,他: "動脈硬化頻発部位の血流動態の計算流体力学的解析" 医療情報学連合大会論文集. 15. 267-268 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsumoto,T et al: "Evaluation of Spatial Control Unit for Regional Myocardial Blood Flow by a Molecular Flow Tracer" The 2nd World Congress of Biomechanics. Abstract. 1. 34-34 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mochizuki,S et al: "Effect of intramyocardial slosh phnomenon on the endothelial cell form of the coronary artery" World congress on medical physics and biomedical engineering.Proceedings. Part 1. 201-201 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Goto,M et al: "Observation of the Thebesian Vein and its Outflow in the Beating Canine Heart" J.Cardiovascular Diagnosis and Procedures. 12. 117-117 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Seiichi Mochizuki他: "Effect of intra-myocardial slosh phenomenon on the endothelial cell form of the coronary artery" Proceedings of the World Congress on Medical Physics and Biomedical Engineering. 1. 201- (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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