| Project/Area Number |
06807036
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Toyo University, School of Medicine |
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Principal Investigator |
KANAMORI Masao Toho University, School of Medicine, Dpt.Occup.& Environ.Health, Associate, Professor, 医学部, 助教授 (90127019)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Minoru Toho University, School of Medicine, Dpt.Occup.& Environ.Health, Professor, 医学部, 教授 (80051845)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Alzheimer's disease / Life-styile / Apolipoprotein E allele / Frequency / Odds ratio / Meta-analysis |
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| Research Abstract |
Frequencies of apolipo-protein E2, E3, E4 allele were 0.056,0.854,0.090 respectively. The frequencies of E4 allele were 0.083 for aged 50-64 and 0.104 for aged 65-74. Our results on the allele frequencies is consistent with our Japanese hospital survey. Lower frequency of E4 allele is cleared in Japanese elderly population compared to Caucasian population. These results confirm the influence of genetic factors and some environmental factors on the prevalence rate of Alzheimer's disease.
A meta-analysis from 15 case-control studies for risk factors of Alzheimer's diseases is presented. Summarized odd's ratio on alcohol drinking by random effect model is 1.19 (95% CI 0.87-1.65) All of summarized odds ratio were found to be larger than 1.00 but no association between alcohol and Alzheimer's disease. Summarized odds ratio on tobacco consumption were found to be smaller than 1.00 (odds : 0.87,95% CI 0.67-1.12) but not significantly association between smoking and Alzheimer's disease.
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