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Targeted Cancer Chemotherapy Used Lipiodol As A Carrier

Research Project

Project/Area Number 06807104
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

KONNO Toshimitsu  The first Department of Surgery Kumamoto University, School of Medicine, Lecture, 医学部附属病院, 講師 (60117348)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
KeywordsLipiodol ultrafluid / Targeted Chemotherapy / Hepatoma / 肝癌 / Lipiodol ultrafluid / Lipiodol ulfrafluid / Targeted cancer chemotherapy / VX2癌 / 油性制癌剤
Research Abstract

SMACS/Lipiodol, which is developed in our clinic and is commercially available in our country is effective for almost all hepatocellular carcinoma (HCC). Actually, 5-year survival of the patients with unresectable HCC treated with SMANCS/Lipiodol is over 30%, and there are many patients cured. Meanwhile, it has not satisfactory antitumor activities against metastatic liver cancer, because of smaller amount of remained Lipiodol in tumor and shorter period of retention of Lipiodol. For treatment of the patients with metastatic liver cancer, many kinds of anticancer agents were dissolved in Lipiodol, and these oily anticancer agents were tested using rabbits bearing implantable VX2 tumor in the liver, sized of 1-2 cm in diameter.
Complete necrosis of the tumor was observed in about 20% of the rabbits treated with SMANCS/Lipiodol. Complete necrosis of the tumor was observed in almost all rabbits treated with Vinblastine/Lipiodol (5 mg/ml), epirubicin/Lipiodol (6mg/ml), and nitromin/Lipiodol (7.5 mg/ml).
Complete necrosis of the tumor with necrosis of liver parenchyma less than 10 mm and over 10 mm surrounding tumor was observed in the rabbits treated with 7.5 mg/ml and 10mg/ml of Vinblastine/Lipiodol, respectively. It is thought that these oily anticancer agents are more effective against metastatic liver cancer compared with SMANCS/Lipiodol.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] T.Konno, Y.Kai, R.Yamashita, A.Nagamitsu and M.Kimura: "Targeted chemotherapy for unresectable primary and metastatic liver cancer" Acta Oncologica. 33. 133-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 今野俊光: "DDSとしてLipiodolを用いたターゲティング療法" カレントテラピー. 13. 156-160 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 今野俊光: "癌のターゲティング療法、油性制癌剤" Practical Oncology. 8. 8-9 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 今野俊光: "癌組織を標的とするターゲティング-油性抗癌剤(SMANCS/Lipiodolを中心に)-" Medico. 27. 21-24 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno: "Artenal Infusion Chemotherapy" T.Taguchi and H.Nakamura.E.d. Jpn. J. Cancer and Chemother. Pub. Inc. Tokyo, 551 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 今野俊光: "消化器病セミナー58.消化器癌の化学療法 -最近の進歩" 栗原稔 編集,へるす出版 東京, 210 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno, Y.Kai, R.Yamashita, A.Nagamitsu, and K.Kimura: "Targeted Chemotherapy for Unresectable Primary and Metastatic Liver Cancer." Acta Oncologica. 33. 133-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno: "Arterial Infusion Chemotherapy" T.Taguchi and H.Nakamura Ed.Jpn.J.Cancer and Chemother. Pub.Inc.Tokyo. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno: "Targeted Cancer Chemotherapy Used Lipiodol as a Carrier. (Japanese)." Current Therapy. 13. 156-160 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno: "Targeting Cancer Chemotherapy-oily anticancer agents-. (Japanese)." Practical Oncology. 8. 8-9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno: "Gastrointestinal Seminar-58, Chemotherapy for Gastrointestinal Cancer. (Japanese)" M.Kurihara Ed.Health Pub.Tokyo. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Konno,Y.Kai,R.Yamashita,A.Nagamitsu and M.Kimura: "Targeted chemotherapy for unresectable primary and metastatic liver cancer" Acta Oncologica. 33. 133-137 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 今野俊光: "DDSとしてLipiodolを用いたターゲティング療法" カレントテラピー. 13. 156-160 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 今野俊光: "癌のターゲティング療法、油性制癌剤" Practical Oncology. 8. 8-9 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Konno: "Artenal Infusion Chemotherapy" T.Taguchi and H.Nakamura.Ed. Jpn.J.Cancer and Chemother.Pub.Inc. Tokyo, 551 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 今野俊光: "消化器病セミナー58.消化器癌の化学療法 -最近の進歩" 栗原稔 編集,へるす出版 東京, 210 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toshimitsu Konno,Yosuke Kai,Ryoichi Yamashita,Akinori Nagamitsu: "Targeted chemotherapy for unresectable primary and metartatic liver cancer" Acta Oncologia. 33. 133-137 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Masami Kimura,Toshimitsu Konno et al: "Intracavital chemotherapy for peritoneal and pleural carcinomatosis with lipid-formulated anticancer agents" Oncology Report. 1. 313-315 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 今野 俊光: "転移性肝癌に対する動注療法" 外科治療. 70. 749-754 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 今野 俊光: "制癌法-この1年の進歩" 人工臓器. 23. 1136-1137 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Toshimitsu Konno: "Arterial Infusion Chemotherapy.Revisede Update Edition." Jpn J.Cancer and Chemother.Pub.Inc., 550 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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