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Precarcerous or preneoplastic lesions in salivary glands

Research Project

Project/Area Number 06807141
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

FUKUSHIMA Masahiro  Niigata Univ. School of Denttistry, Associate Professor, 歯学部, 助教授 (00018631)

Co-Investigator(Kenkyū-buntansha) SAKU Takashi  Niigata Univ.School of Dentistry, Professor, 歯学部, 教授 (40145264)
SUZUKI Makoto  Niigata Univ. Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (50107778)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsFGF / PCNA / Salivary gland / Salivary gland tumor / Precancer / Pleomorphic adenoma / Adenoid cystic carcinoma / Mucoepidermoid carcinoma / 唾液腺腫瘍
Research Abstract

We have collected 212 cases of benign and malignant tumors arising in the major and minor salivary glands. These cases were selected from the surgical pathology files in the Department of Oral Pathology, Niigata University Dental Hospital in the past 29 years. HE stained sections of these 212 cases were reviwed by the three pathologists independently, then rediagnosed histopathologically according to the WHO Histological Typing of Salivary Gland Tumors. At the same time, we examined the normal salivary gland tissue neighouring the tumor nests on the same slides. Hyperplastic and dysplastic changes in the ducts were discovered in the normal gland tissue next to both benign and malignant salivary gland tumors. The incidence of atypical salivary ducts were as follows : 24% in pleomophic adenoma, 21% mucoepidermoid carcinoma, 5% adenoid cystic carcinoma, and the incidence in minor salivary glands were 82%, 70% and 53%, respectively. Furthermore, we prepared 5mu serial sections from formalin fixed and paraffin embedded blocks, and performed various kinds of histochemical stainings and immunohistochemical stainings for aFGF,bFGF and PCNA with the PAP or ABC methods. The positive reactions for bFGF and PCNA were frequently detected in the dysplastic ductal structures. After reviewing the immunostained samples that the ductal hyperplasia and dysplasia came to be visible microscopically, even in HE stained samples. The results suggest that there is a borderlin (precancerous) lesion of the salivary gland, which is regarded as a process of tumor formation.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 野村 務 他: "頭頚部重複癌10例の臨床病理組織学的検討" 口腔外科学会誌. 40. 203 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 周 静 他: "乳歯の歯髄処置後の根尖性歯周炎が原因と考えられる下顎第2小臼歯の含歯性嚢胞の1例" 新潟歯学会誌. 24. 73 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 鶴巻 浩 他: "舌上皮内癌と上咽頭癌が重複した1例" 口腔腫瘍誌. 6. 171 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Nomura, Tsutomu et al.: "A clinicopathological study of 10 primary multiple cancers of head and neck" Jpn. J.Oral Maxillofac. surg.40 (1). 203-205 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Zhou, Jing et al.: "Dentigerous cyst arising the second premolar in the mandible, possibly caused by periapical periodontitis of the deciduous molar under endodontic treatment" Niigata Dent. J.24 (1). 73-80 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsurumaki, Hiroshi et al.: "A case of the double cancer in the tongue (carcinoma in situ) and the nasopharynx" J.Jpn. Soc. Oral Tumor. 6 (2). 171-172 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 野村 務 他: "頭頸部重複癌10例の臨床病理組織学的検討" 口腔外科学会誌. 40. 203 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 周 静 他: "乳歯の歯髄処置後の根尖性歯周炎が原因と考えられる下顎第2小臼歯の含歯性嚢胞の1例" 新潟歯学会誌. 24. 73 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 鶴巻 浩 他: "舌上皮内癌と上咽頭癌が重複した1例" 口腔腫瘍誌. 6. 171 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 野村 務 他: "頭頚部重複癌10例の臨床病理組織学的検討" 口腔外科学会誌. 40. 203 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 周 静 他: "乳歯の歯髄処置後の根尖性歯周炎が原因と考えられる下顎第2小臼歯の含歯性嚢胞の1例" 新潟歯学会誌. 24. 73 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 鶴巻 浩 他: "舌上皮内癌と上咽頭癌が重複した1例" 口腔腫瘍誌. 6. 171- (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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