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A diagnostic study of lectin binding pattern and color variation in oral mucosal epithelium on diseases of the oral mucosa

Research Project

Project/Area Number 06807148
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionTohoku University

Principal Investigator

MARUMO Machiko  Tohoku University, School of Dentistry, Lecturer, 歯学部, 講師 (10005027)

Co-Investigator(Kenkyū-buntansha) SANJO Daisuke  Tohoku University, School of Dentistry, Professor, 歯学部, 教授 (70013943)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsOral Mucosa / Lichen Planus / Lectin Binding Pattern / Color / 口腔粘膜疾患 / 糖鎖 / レクチン結合様式
Research Abstract

Many kinds of diseases of oral mucosa are unknown etiology. Usually clinical pattern shows bullous, erosive, keratinize, ulcerative leasions, so leading to differential diagnosis is difficult.
The purpose of in this study was to examine possible epithelial cell membrane changes in lichen planus affected by the use of the WGA and the color variation in various clinical types of the lichen planus (OLP).
The results were obtained as follows.
1) The binding of the epithelium to wheat germ agglutinin (WGA) was examined.
In healthy oral mucousal epithelium, the binding pattern was obserbed regularly and strong but in OLP irregularly and weak in various clinical types especialy most decrease in lectin binding was observed in erosive lesion.
2) We measured the color variation of the epithelium by CHROMA meter CS-100(MINOLTA). The color space (CIE 1976 L^<**>a^<**>b^<**>) and the color difference (CIE 1976 DELTAE^<**>ab) were examined.
Compare to healthy mucousal epithelium with lichen planus, the color space L^<**> and b^<**> were minus quantity, a^<**> was plus quantity.
The color differrence DELTAE^<**>ab was higher about 7th levels.
3) We measured the pain caused by OLP quantativery, using a visual analogue scale (VAS). The score showed a change in various clinical types and better by clinical therapies. The color variation and VAS showed corelatively changes.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 丸茂町子: "口腔扁平苔癬のビオチン化レクチンによる組織学的研究" 日本口腔診断学会誌. 8. 303-312 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 菅原由美子: "口腔粘膜扁平苔癬の組織化学的研究" 日本口腔科学会雑誌. 44. 285 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 菅原由美子: "口腔扁平苔癬のレクチン結合様式に関する透過型電顕的検討" 日本口腔粘膜学会雑誌. 1. 25 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 丸茂町子: "口腔扁平苔癬の色調に関する客観的測定法の検討" 第9回日本口腔診断学会発表予定. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 丸茂町子: "口腔扁平苔癬の色調と疼痛に関する客観的測定法の検討" 第6回日本口腔粘膜学会発表予定. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Machiko Marumo: "A Histchemical Study with Biotynyl Lectin on the Oral Lichen Planus" Jpn J Oral Diag Oral Med. 8. 303-312 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yumiko Sugawara: "A Histchemical Study on the Oral Lichen Planus" J Jpn Stomatol Soc. 44. 285 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yumiko Sugawara: "A Ultramicroscopic Study with Biotynyl Lectin on the Lichen Planus" J Jpn Oral Muco. 1. 25 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Machiko Marumo: "The Quantitative Measurement of Color Variation on the Oral Lichen Planus" Jpn J Oral Diag Oral Med. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Machoko Marumo: "The Quantitative Measurement of Pain and Color Variation on the Oral Lichen Planus" J Jpn Oral muco. (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 丸茂町子: "口腔扁平苔癬のビオチン化レクチンによる組織化学的研究" 日本口腔診断学会誌. 8. 303-312 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 菅原由美子: "口腔粘膜扁平苔癬の組織化学的研究" 日本口腔科学会雑誌(抄). 44. 285 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 菅原由美子: "口腔扁平苔癬のレクチン結合様式に関する透過型電顕的検討" 日本口腔粘膜学会雑誌(抄). 1. 25 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 丸茂町子: "口腔扁平苔癬の色調に関する客観的測定法の検討" 第9回日本口腔診断学会. (発表予定). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 丸茂町子: "口腔扁平苔癬の色調と疼痛に関する客観的測定法の検討" 第6回日本口腔粘膜学会. (発表予定). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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