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Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia

Research Project

Project/Area Number 07041118
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionHokkaido University

Principal Investigator

KIDA Hiroshi  Hokkaido Univ., Graduate School of Vet.Medicine, Professor, 大学院・獣医学研究科, 教授 (10109506)

Co-Investigator(Kenkyū-buntansha) YAMNIKOVA Svetrana  Russian Academy of Science, Ivanovsky Virus Institute, Professor, イワノフスキーウイルス研究所, 教授
KAWAOKA Yoshihiro  Winsconsin Univ., Faculty of Veterinary Medicine, Professor, 獣医学部, 教授
TAKADA Ayato  Hokkaido Univ., Graduate School of Vet.Medicine, Instructor, 大学院・獣医学研究科, 助手 (10292062)
OKAZAKI Katsunori  Hokkaido Univ., Graduate School of Vet.Medicine, Associate Professor, 大学院・獣医学研究科, 助教授 (90160663)
SVETRANA Yam  ロシア科学アカデミー, イワノフスキーウイルス研究所, 教授
デメネフ V.  ロシア極東医学協会, 副会長
ヤムニコバ S.  ロシア科学アカデミー, イワノフスキーウイルス研究所, 教授
ルボフ D.K.  ロシア科学アカデミー, イワノフスキーウイルス研究所, 所長
伊藤 壽啓  鳥取大学, 農学部, 助教授 (00176348)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥16,100,000 (Direct Cost: ¥16,100,000)
Fiscal Year 1997: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1996: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
Keywordsinfluenza virus / migratory ducks / feces / breeding areas / Siberia / lake water / The River Lena / Southern China / 水禽 / 渡り鳥 / ニューキャッスル病ウイルス / アムール河
Research Abstract

In each summer of 1995-1997,3,000 fecal materials of waterfowls and lake-water samples were collected in Kamchatka, Khabarovsk, and Saha Republic. In 1996, out of 900 fecal samples collected in Kobyaysky area of the basin of the River Lena, 60゚30'N,19 H4N6,1 H4N9,1 H11N1,2 H11N6, and 8 H11N9 influenza viruses were isolated. Although no virus was isolated from the samples collected in "40 islands" area of the River Lena (65゚00'-64゚34'N) , 1 H4N6 and 5 H3N8 viruses were isolated from 120 samples collected in Kobyaysky area and 72 samples in Yakutsk (62゚05'N) , respectively, in 1997. No influenza virus was isolated from the samples collected in Kamchatka or Khabarovsk. These data may indicate that breeding areas of ducks are located around 63゚N of the basin of the River Lena.
In each October of 1996 and 1997,480 fecal samples of waterfowls were collected in Soya, Hokkaido. From those, a-strain of H1N1, H5N3, H5N4, H6N1, H6N7, H8N1, H8N3, H9N2, and H11N9 influenza virus was isolated.
Phylogentic analysis of NP genes of the isolates from fecal samples collected in Siberia and Hokaido are showed that thses strains belong to the Eurasian lineage of avian influenza viruses. The viruses in Siberia are brought to southern China, possible epicenter of influenza, by migration of ducks. Further surveillance studies of migratory birds in Siberia, should povide information on the new pandemic influenza viruses.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] Y.Gou: "Seroepidemiological and molecular evidence for the presence of two H3N8 equine influenza viruses in China in 1993-94." J.Gen.Virol.76. 2009-2014 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C.Rohm: "Do hemagglutinin genes of highly pathogenic avian influenza viruses constitute unique phylogenetic lineages?." Virology. 209. 664-670 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Horimoto: "The hemagglutinin cleavability of a virulent avian influenza virus by subtilisin-like endoproteases is influenced by the amino acid immediately downstream of the cleavage site" Virology. 210. 466-470 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.R.Castrucci: "Reverse genetics system for generation of an influenza A virus mutant containing a deletion of the carboxyl-terminal residue of M2 protein" J.Virol.69. 2725-2728 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] D.S.Senne: "Survey of the hemagglutinin(HA)cleavage site sequence of H5 and H7 avian influenza viruses:Amino acid sequence at the HA cleavage site as a marker of pathogenicity potential." Avian Dis.40. 425-437 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.J.Mitnaul: "The cytoplasmic tail of influenza A virus neuraminidase(NA)affects NA incorporation into virions,virion morphology,and virulence in mice but not essential for virus replication." J.Virol.70. 373-379 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito: "Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species." Virology. 227. 493-499 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 喜田 宏: "インフルエンザウイルスの生態-新型ウイルスの出現に備えて-" 蛋白核酸酵素. 42. 145-153 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito: "Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection." J.Virol.71. 3357-3362 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.B.Sharp: "Coinfection of wild ducks by influenza A viruses:distribution patterns and biological significance." J.Virol.71. 6128-6135 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Horimoto: "Biologic effects of introducing additional basic amino acid residues into the hemagglutinin cleavage site of a virulent avian influenza virus." virus Res.50. 35-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.Campitelli: "continued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy." Virology. 232. 310-318 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 喜田 宏: "動物界におけるインフルエンザウイルスの生態と新型ウイルス出現のメカニズム" 日本臨床. 55(10). 2521-2526 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imai, M.: "Fusion of influenza virus with the endosomal membrane is inhibited by monoclonal antibodies to defined epitopes on the hemagglutinin." Virus Res.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito: "Receptors of influenza A viruses:Implications for the role of pigs for the generation of pandemic human influenza viruses.In:Brown,L.E.,Hampson,A.W.,and Webster,R.G.eds.Options for the control of influenza III" Elsevier, 860 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Kida: "Avian influenza viruses as the origin of pandemic strains:perpetuation in nature and potential for transmission to pigs.In:Brown,L.E.,Hampson,A.W.,and Webster,R.G.eds.Options for the control of influenza III" Elsevier, 860 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Guo, et al.: "Seroepidemiological and molecular evidence for the presence of two H3N8 equine influenza viruses in China in 1993-94" J.Gen.Virol.76. 2009-2014 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] C.Rohm, et al.: "Do hemagglutinin genes of highly pathogenic avian influenza viruses consttute unique phylogenetic ineages?" Virology. 209. 664-470 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Horimoto, et al.: "The hemagglutinin cleavability of a virulent avian influenza virus by subtilisin-like endoproteases is influenced by the amino acid immediately downstream of the cleavage site" Virology. 210. 466-470 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.R.Castrucci, et al.: "Reverse genetics sytem for generation of an influenza A virus mutant containing a deletion of the carboxyl-te, et al., rminal residue of M2 protein" J.virol.69. 2725-2728 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] D.S.Senne, et al.: "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses : Amino acid sequence at the HA cleavage site as a marker of pathogenicity potential" Avian Dis.40. 425-427 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.J.Mitnaul, et al.: "The cytoplasmic tail of influenza A virus neuraminidase (NA) affects NA incorporation into virions, virion morphology, and virulence in mice but not essential for virus replication" J.Virol.70. 373-379 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito, et al.: "Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species" Virology. 227. 493-499 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kida, H.: "Ecology of infruenza viruses : Are we prepared for the emergence of the next pandemic of influenza? (in Japanese)" Tanpakushitu Kakusan kouso. 42. 145-153 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito, et al.: "Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection" J.Virol.71. 3357-3362 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] L.Campitelli, et al.: "Continued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy" Virology. 232. 310-318 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Horimoto, et al.: "Biologic effects of introducing additional basic amino acid residues into the hemagglutinin cleavage site of a virulent avian influenza virus" Virus Res.50. 35-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.B.Sharp, et al.: "Coinfection of wild ducks by influenza A viruses : distribution patterns and bilogical significance" J.Virol.71. 6128-6135 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Ito, et al.: "Receptors of influenza A viruses : Implications for the role of pigs for the generation of pandemic human influenza viruses" In : Brown, L.E., Hampson, A.W., and Webster, R.G.eds.Options for the control of influenza III. 516-519 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Kida, et al.: "Avian influenza viruses as the origin f pandemic strains : perpetuation in nature and potential for transmission to pigs" In : Brown, L.E., Hampson, A.W., and Webster, R.G.eds.Options for the control of influenza III. 529-536 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Kida: "Ecology of influenza viruses : Mechanism of emergence of the pandemic strain (in Japanese)" Nihonrinsyo. 55. 2521-2526 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Imai, et al.: "Fusion of influenza virus with the endosomal membrane is inhibited by monoclonal antibodies to defined epitopes n the hemagglutinin" Virus Res.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, T.: "Differences in sialic acid-galactose linkages in the chicken egg aminion and allantois influence human influenza virus receptor specificity and variant selection." Journal of Virology. 71(4). 3357-3362 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Campitelli, L.: "Cotinued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy." Virology. 232(2). 310-318 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Horimoto, T.: "Biologic effects of introducing additional basic amino acid residues into the hemagglutinin cleavage site of a virulent avian influenza virus." Virus Research. 50(1). 35-40 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sharp, G. B.: "Coinfection of wild ducks by influenza A viruses: distribution patterns and biological significance." Journal of Virology. 71(8). 6128-6135 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 喜田 宏: "動物界におけるインフルエンザウイルスの生態と新型ウイルス出現のメカニズム" 日本臨床. 55(10). 2521-2526 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Imai, M.: "Fusion of influenza virus with the endosomal membrane is inhibited by monoclonal antibodies to defined epitopes on the hemagglutinin." Virus Research. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Ito: "Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection" J.Virol.71(印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 喜田宏: "インフルエンザウイルスの生態-新型ウイルスの出現に備えて-" 蛋白核酸酵素. 42. 145-153 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] D.S.Senne: "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses : Amino acid sequence at the HA cleavage site as a marker of pathogenicity potential." Avian Dis.40. 425-437 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] L.J.Mitnaul: "The cytoplasmic tail of influenza A virus neuraminidase (NA) affects NA incorporation into virions,virion morphology,and virulence in mice but not essential for virus replication." J.Virol.70. 873-879 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Ito: "Receptors of influenza A viruses : Implications for the role of pigs for the generation of pandemic human influenza viruses. In : Brown,L.E.,Hampson,A.W.,and Webster,R.G.eds.Options for the control of influenza III" Elsevier, 860 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Kida: "Avian influenza viruses as the origin of pandemic strains : perpetuation in nature and potential for transmission to pigs. In : Brown,L.E.,Hampson,A.W.,and Webster,R.G.eds.Options for the control of influenza III" Elsevier, 860 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T. Ito: "Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species" Virology. (投稿中).

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Ito: "Continued circulation of reassortant H1N2 influenza viruses in pigs in Japan" Virology. (投稿中).

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Guo: "Seroepidemioiogical and molecular evidence of the presence of two H3N8 equine influenza viruses in China in 1993-94." J. Gen. Virol.76. 2009-2014 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Horimoto: "Thc hcmagglutinin clcavability of a virulont avian influenza viruses by subrtilisin-like endoproteases is influenced by the amino acid immediately down-stream of the cleavage site" Virology. 210. 466-470 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] C. Rohm: "Do hemagglutinin genes of highly pathogenic avian influenza viruses constitute unique phylogenetic lineages?. Virology. 209: 664-70, 1995." Virology. 209. 664-670 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M. R. Castrucci: "Reverse genetics system for generation of an influenza A virus mutant containing a deletion of the carboxyl-terminal residue of M2 protein" J. Virol.69. 2725-2728 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Kawaoka: "Orthomyxoviruses: Influenza. In: Topley & Wilson's Microbiology and Microbial Infections, 9th ed." Edward Arnold, London(印刷中),

    • Related Report
      1995 Annual Research Report
  • [Publications] 喜田 宏: "家禽ペスト獣医伝染病学、第4版、清水悠紀臣等編" 近代出版、東京, 1 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 喜田 宏: "インフルエンザ(家禽ペスト)カラーマニュアル鳥の病気、鶏病研究会編" 鶏病研究会、東京, 4 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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