| Project/Area Number |
07041166
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Field |
Ophthalmology
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| Research Institution | Yokohama City University |
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Principal Investigator |
OHNO Shigeaki Yokohama City University, School of Medicine, Professor, 医学部, 教授 (50002382)
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| Co-Investigator(Kenkyū-buntansha) |
TABBARA Khalid.F King Saud Univ, Sch of Med, Professor, 医学部, 教授
NAKAMURA Satoshi Yokohama City University, School of Medicine, Associate Professor, 医学部, 講師 (00237398)
SUGITA Miyuki Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (90235888)
ONOE Kazunori Hokkaido Univ Institute of Immun Sci, Professor, 免疫科学研究所, 教授 (40002117)
INOKO Hidetoshi Tokai Univ., Sch of med, Professor, 医学部, 教授 (10101932)
CRISTBOL A C Buenos Aires大学, 医学部, 講師
庚 鎮城 中国復旦大学, 教授
RUBENS Belfo Paulista医科大学, 医学部, 教授
KHALID F Tab King Saud大学, 医学部, 教授
新藤 裕実子 横浜市立大学, 医学部浦舟病院, 助手 (50285128)
伊藤 典彦 横浜市立大学, 医学部, 助手 (80264654)
内尾 英一 横浜市立大学, 医学部, 講師 (70232840)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 1997: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1996: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1995: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Intractable uveitis / Mongoloid / Molecular genetics / Molecular biology / Mechanism of disease / HLA / Behcet's disease / 難治性ぶどう膜性 / 原田病 / HLA遺伝子 / MICA遺伝子 / ぶどう膜炎 |
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| Research Abstract |
Anthropological and molecular genetic studies on intractable uveitis syndromes which are frequently seen in the Mongoloid population were performed in Syria, Jordan, Mongol and Portugal in the fiscal year of 1997.
In Syria and Jordan, there were many patients with Behcet's disease, and most of the patients in the Ophthalmology Department as well as the Rheumatology Department were those with Behcet's disease, quite similar to Japan. However, Vogt-Koyanagi-Harada's disease was rarely seen in these countries. In Syria, uveitis survey clinic was not yet established, and we advised them how to establish this for our future cooperative studies. In Jordan, however, a speciality clinic for Behcet's disease was already established, and we could see more than 50 typical cases of Behcet's disease. We could also get blood samples from these patients for the HLA-DNA typing. Molecular genetic analyzes on these samples are now in progress in our laboratory.
In Mongolia, there were many patients with i
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ntractable uveitis syndromes, and typical cases with Behcet's disease or Vogt-Koyanagi-Harada's disease were seen. On the other hand, no patients were diagnosed as sarcoidosis in Mongolia. Clinical festures of uveitis in Mongolia was generally similar to Japan, as had been expected. In this investigation, we could establish a scientific basis for future cooperative studies.
Portugal is located in the west end of the so-called Silk-Route, and similar to Japan and other Mediterranean countries, there were many Portuguese patients with Behcet's disease. However, Vogt-Koyanagi-Harada's disease or sarcoidosis was not as frequent as in Japan. In the next study, association of HLA-B^<**>5101 is to be studied in Portuguese patients with Behcet's disease.
Blood samples collected before from Saudi Arabia or Greece were also HLA-DNA typed in our laboratory this year, and the same HLA class I association with Japanese patients was found in these patients.
We can conclude from these results that certain types of intractable uveitis frequently seen in the Mongoloid population are also seen along with the Silk-Route, and these uveitis may have been spread along with the migration of the old Nomadic Tibes. Less
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