| Project/Area Number |
07041167
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | Kyorin University School of Medicine |
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Principal Investigator |
ENDOU Hitoshi Department of Pharmacology and Toxicology, School of Medicine, Kyorin University, Professor, 医学部, 教授 (20101115)
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| Co-Investigator(Kenkyū-buntansha) |
河合 祥雄 順天堂大学, 医学部, 講師 (40138194)
SAMAISUKH So マヒドン大学, 理学部, 助教授
JUTAMAAD Sat マヒドン大学, 理学部, 助教授
PAWINEE Piya マヒドン大学, 理学部, 講師
CHUMPOL Pholpramool Department of Pharmacology, Faculty of Science, Mahidol University, 理学部, 助教授
SUMALEE Nimm マヒドン大学, 医学部, 教授
CHIBA Momoko Department of Hygiene, School of Medicine, Juntendo University, 医学部, 助教授 (80095819)
KOMATSU Yasuhiro Department of Pediatric Nephrology, Tokyo Women's Medical College, 医学部, 助手 (60195849)
INABE Yutaka Department of Hygiene, School of Medicine, Juntendo University, 医学部, 教授 (30010094)
IGARASHI Takashi Department of Pediatrics, Faculty of Medicine, Mejirodai Campus, The University, 医学部, 講師 (70151256)
SAMAISUKUH Sophasan Department of Physiology, Faculty of Science, Mahidol University
JUTAMAAD Satayavivad Department of Pharmacology, Faculty of Science, Mahidol University
PAWINEE Piyachaturawat Department of Physiology, Faculty of Science, Mahidol University
SUMALEE Nimmannit Department of Medicine, Faculty of Medicine, Mahidol University
SAMAISUKH S マヒドン大学, 理学部, 助教授
JUTAMAAD Sa マヒドン大学, 理学部, 助教授
PAWINEE Piy マヒドン大学, 理学部, 講師
CHUMPOL Pho マヒドン大学, 理学部, 助教授
SUMALEE Nim マヒドン大学, 医学部, 教授
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 1996: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1995: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | Distal renal tubular acidosis / urinary stone / hypo-kelamic periodic paralysis / urinary vanadium / trace element / sodium pump / animal model / environmental substance (water, soil) / 遠位尿細管性酸血症麻痺 / 低カリウム性周期性四肢 / 低カリウム性酸血症麻痺 |
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| Research Abstract |
In order to identify possible causes of sudden unexplained death syndrome (SUDS) -related endemic diseases (including distal renal tubular acidosis, hypokalemic periodic paralysis and urinary stone) in North-East Thailand, a fieldwork and laboratory investigations were carried out.
1. Fieldwork
We visited villagers in Yasothorn district whose members were suffered from SUDS,and made interviews. As analytical samples, their blood, urine, water and soil were collected for the determination of various elements including Vanadate (V).
1) Genetic factors
Since the local definition of SUDS is different from clinical one, it was difficult to identify a possibility of genetic diathesis. Nevertheless, blood and urine samples were collected from a limited number of SUDS-relatives for further analysis of DNA to look for abnormal genes in familiar QT elongation syndrome.
2) Acquired factors
We analyzed 43 different elements in the collected samples from North-East (NE) and Bangkok (BK) as controls. Vanadium contents in soils and water revealed no difference between NE and BK,whereas contents of Ca, Mg, K and Pb in soil were higher in BK than NE.Only Na in NE was higher than NE.V contents in plasma and urine in NE villagers were higher than BK.These results suggest that even under low plasma K in NE villagers their intracellular K could be maintained at relatively high levels, and that one of causes of the endemic diseases may be disturbance of this K-retaining mechanism.
2. Animal model experiments
The treatment of rats with low potassium diet for longer time than 1 month cased hypo-potassemia, and revealed abnormality in cardiac and renal functions. Since no SUDS occurred under the hypo K,additional factors e.g.low Mg should be investigated.
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