| Project/Area Number |
07042001
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
NISHIHARA Tetsuro The 2nd Department of Surgery, TOHOKU Univ. School of Medicine, Associate Professor, 医学部, 助教授 (50101142)
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| Co-Investigator(Kenkyū-buntansha) |
SIMON S.L. Marshall Islands Nationwide Radiological Study, 所長
TROTT K.R Department of Radiation Biology : Univ. of London, 教授
TAGUCHI Yoshio TOHOKU Univ. International Student Center, 留学生センター, 教授 (70004885)
KIMURA Noriko The 2nd Department of Surgery, TOUFUKU Univ. School of Medicine, 医学部, 助手 (80142975)
DOI Hideyuki The 2nd Department of Surgery, TOUFUKU Univ. School of Medicine, 医学部附属病院, 助手 (90188839)
KUROKAWA Yoshimochi The 2nd Department of Surgery, TOUFUKU Univ. School of Medicine, 医学部附属病院, 助手 (80215087)
FUJIMORI Keisei The 2nd Department of Surgery, TOUFUKU Univ. School of Medicine, 医学部附属病院, 助手 (50238622)
SHINEHA Ryuzaburo The 2nd Department of Surgery, TOUFUKU Univ. School of Medicine, 医学部, 講師 (20192106)
SATOMI Susumu The 2nd Department of Surgery, TOHOKU Univ. School of Medicine, 医学部, 教授 (00154120)
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| Project Period (FY) |
1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1995: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | Thyroid Cancer / Radiation Exposure / The Republic of Marshall Islands / Nodular Goiter / Iodine Intake / Ultrasound Image Scanning / Atomic Bomb Test |
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| Research Abstract |
To study the correlation between the prevalence of thyroid nodules and of thyroid cancer in the population of the Marshall Islands and radiation exposure from atomic bomb test conducted by USA from 1984 to 1959,6,638 residents on Ebeye in the Kwajalein Atoll and on the Majuro Atoll were investigated using ultrasound imaging of the thyroid and fine needle aspiration biopsy cytology (FNABC). A personal interview on a complete residence history, a diet habit and a fertility of history of each participant was conducted by native assistants. The prevalence of thyroid nodules in female alive during the atomic bomb tests was over 40% and increased by aging. From the FNABC findings and the pathological findings of wxcised thyroid among the Ebeye participants, cancer prevalence was estimated as about 2% in those women. We examined blood TSH value for 2,102 participants, auto antibody (TGHA and MCHA) for 3,008 participants, and iodine concentration of casual urine samples for 310 participants in Majuro. The prevalence of chemical hypothyroidism (TSH>5.0 mc U/ml) was 0.5% and of positive antibody was 2.5% in those participants. From the results of the creatinine/iodine ratio in casual urine samples. 22% of the pariticipants were estimated as moderate or severe iodine deficiency on WHO guideline.
High prevalence of thyroid nodules and thyroid cancer in Marshall Islands people who had not been in Rongelap or Utrik during "BRAVO" test may be caused by radiation exposure from atomic bomb test. On the other hand low iodine intake in Marshallese might be considered as a cause of it. Data base of medical results and interview records of each participants is now going to be completed and dosimetry will be performed by Prof. Trott in London in 1996. Statistical analysis will clear relationship between estimated radiation dose and prevalence of thyroid cancer or thyroid nodules in Marshall Islands.
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