| Project/Area Number |
07042004
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Nagoya University |
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Principal Investigator |
OHNO Yoshiyuki Nagoya University, School of Medicine, Professor, 医学部, 教授 (10160590)
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| Co-Investigator(Kenkyū-buntansha) |
DILLON Drupadi Department of Nurtrition, University of Indonesia, School of Medicine, dietitian, 医学部・栄養学, 栄養士
BUDININGSIH Setyawati Department of Community Medicine, University of Indonesia, School of Medicine, L, 医学部・地域医療学, 講師
RAMLI Muchlis Division of Surgical Oncology, University of Indonesia, School of Medicine, Doct, 医学部・中央病院・腫瘍外科, 医師
TJAHJADI Gunawan Department of Anatomic Pathology, University of Indonesia, School of Medicine, H, 医学部・解剖病理・乳腺病理, 主任
CORNAIN Santoso Laboratory of Immunology, Dept.University of Indonesia, School of Medicine, Head, 医学部・免疫研, 主任
WAKAI Kenji Nagoya University, School of Medicine, Doctor, 医学部, 助手 (50270989)
SAKAMOTO Goi Department of Breast Pathology, Cancer Institute, Chief, 病理部・病理部, 部長 (80085620)
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| Project Period (FY) |
1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1995: ¥3,300,000 (Direct Cost: ¥3,300,000)
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| Keywords | Breast cancer / Case-control study / Indonesia / Risk factors / Nutrition / Fat / 脂肪 |
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| Research Abstract |
In order to disclose the role of dietary factors in female breast cancer in Indonesia, a case-control study has been undertaken including a nutritional interview in Jakarta since 1992. Epidemiological and nutritional information was collected for 226 cases and 452 controls as of the end of January, 1996. The preliminary analysis revealed the following findings. (a) The more the intake (per calorie) of protein, fat, calcium, phosphorus, retinol and ascorbic acid, the higher the risk of breast cancer. Remarkable positive association was detected particularly for fat intake. The odds ratios (ORs) for the second, third and fourth quartile, relative to the first quartile, were 2.66,4.28 and 5.52, respectively (trend p=2*10^<-9>). (b) In contrast, carbohydrate intake per calorie was strongly and negatively associated with the risk ; the corresponding ORs being 0.73,0.45 and 0.20, respectively (trend p=3*10^<-9>). These results, along with the findings obtained by our previous case-control study which used a food frequency method, suggest that excess fat intake may increase breast cancer risk in Indonesian females.
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