| Project/Area Number |
07042005
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Osaka University |
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Principal Investigator |
AOZASA Katsuyuki Osaka University, Medical School Professor, 医学部, 教授 (30115985)
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| Co-Investigator(Kenkyū-buntansha) |
KOJYA Shizuo University of Ryukyus, School of Medicine Lecturer, 医学部, 講師 (60161923)
TAGAWA Shin-ichi Osaka City University, Medical School Associate Professor, 医学部, 助教授 (70171569)
TOMITA Yasuhiko Osaka University, Medical School Assistant, 医学部, 助手 (60263266)
KANNO Hiroyuki Osaka University, Medical School Assistant, 医学部, 助手 (40252663)
OHSAWA Masahiko Osaka University, Medical School Assistant, 医学部, 助手 (80213685)
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| Project Period (FY) |
1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Nasal T-cell / Epstein-Barr virus / PCR method / lymphoma In situ hybridization / Pathoepidemiology |
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| Research Abstract |
Nasal T-cell lymphoma (NTL) is one of diseases clinically showing lethal midline granuloma. Histologically NTL shows polymorphous pattern of cellular proliferation, thus also having been called as polymorphic reticulosis (PR). Our previous study showed the incidence rate of NTL per 100, 000 patients visiting Ear-Nose-Throat Clinic was 8.0 in Japan other than Okinawa, 27.4 in Okinawa, 40.8 in Seoul (Korea), and 9.8 in Shanghai (China), which were higher than that in England. Recent study suggested the etiological role of Epstein-Barr virus (EBV) for development of NTL.In the current study, correlation between the incidence rate of NTL and frequency of EBV positivity in the proliferating cells was examined. For this purpose, nasal lymphoma in Okinawa (20 cases) and Osaka (32 cases) were selected for histologic and immunohistochemical studies. Presence of EBV was examined by the PCR and in situ methods.
Immunohistochemically, 27 cases were B cell type (20 Osaka, 7 Okinawa), 20 were T cell type (9 Osaka, 11 Okinawa), and 5 were undefined. EBV genome was found in 6 of 15 cases (40%) and 4 of 5 cases (80%) of nasal B and T cell lymphomas in Osaka and 3 of 7 cases (43%) and 7 of 7 cases (100%) in Okinawa, showing the different frequencies of positivity by immunophenotype but not by district. These findings suggest that EBV might be a causative factor in sino-nasal lymphoma of not only T cell but also B cell type in Japan. Meanwhile the higher incidence of NTL in Okinawa than in Osaka could not be explained by the different positivity ratio of EBV in the tumors. Other factors such as environmetal or life style on the development of NTL might be important.
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