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HTLV-infection and diseases in South America and Caribbean

Research Project

Project/Area Number 07042007
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research Field Virology
Research InstitutionKagoshima University

Principal Investigator

SONODA Shunro  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (40036463)

Co-Investigator(Kenkyū-buntansha) YASHIKI Shinji  Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (40182315)
FUJIYOSHI Toshinobu  Kagoshima University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50173480)
TAKEZAKI Toshiro  Aichi Cancer Center Research Institute, Division of Epidimiology, scholar, 研究員 (50227013)
HAYAMI Masanori  Kyoto University, Institute for virus Research, Professor, ウイルス研究所, 教授 (40072946)
LUIS Hurtado  ボリビア医学会, 名誉教授
BYRNES John  マイアミ大学, 医学部, 教授
HANCHARD Bar  ウエストインディー大学, 医学部, 教授
LUIS Hurtad  ボリビア医学会, 名誉教授
WILLIAM J.Ha  マイアミ大学, 医学部・内科学, 助教授
ABRAHAM Blan  バジェ大学, 医学部, 準教授
VLADIMIR Zan  バジェ大学, 医学部・内科学, 教授
BARRIE Hanch  ウエストインデイー大学, 医学部・病理学, 教授
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 1997: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1996: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1995: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsHTLV-I / HLA / Andes Natives of South American / Easter Island / HAM / TSP / ATL / disease susceptibility / ethnoeoidemiology / II / アンデス先住民 / ジャマイカ黒人 / HLAハプロタイプ / 疾病感受性 / モンゴロイド
Research Abstract

In order to elucidate the susceptibility to HTLV-I/II infection and diseases, we investigated HTLV-I and II infection foci amang South American and Caribbean populations. In this study, we have collected blood samples from the Andes native populations of Bolivia, Peru, Colombia, Chile and Argentina, the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile, as well as Black population of Jamaica, Colombia and Brazil, under informed consent.
HTLV-I foci were found among the Andes native populations of Bolivia, Peru, colombia, chile and Argentina. On the otherhand, HTLV-II foci were identified among the Orinoco low-land population of Colombia and Venezuela, and the Patagonia low-land population of Chile. Thus, the distribution of HTLV-I and HTLV-II foci are geographically sagregated each other. HLA background of HTLV-I carriers of the South American natives showed common HLA class I and II alleles of HTLV-I carriers of Southern Japanese and ethno-specific HLA alleles.
We investigated HTLV-I immunoepitopes recognized by the HLA alleles at risk for ATL and HAM/TSP.Thus, HLA class I A26^<**>, B^<**>4002/6 were at risk for ATL and rhese HLA alleles lacked anchor motifs in HTLV-I Tax peptides. While HLA class I A24, B^<**>07 were at risk for HAM/TSP and these HLA alleles showed many anchor motifs in HTLV-I Tax peptides.
The blood samples collected in this study have been consisted of live lymphocytes bank and plasma bank, which are available for seroepidemiolgical examination and immunogenetical analysis.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Miura.T, Yamashita M, et al.: "Molecular phylogeny of human T-cell leukemia virus type I and II of Amerndians in Colombia and Chile." J.Mol.EVol. 44. 76-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sameshima A, Fujiyoshi T, et al.: "Demonstration of antibodies against human papillomavirus type 11-E-6 and L2 proteins in patients with recurrent respiratory papillomatosis." Auris Nasus Larynx. 24. 185-191 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kubo K, Fujiyoshi T, et al.: "Lack of association of Borna disease virus and human T-cell leukemia virus type-1 infection with psychiatric disorders among Japanese patients." Clin.Diagn.Lab.Immunol.4. 189-191 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamano Y, Kitze B, et al.: "Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP" J.Neuroimmunol.76. 50-60 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitze B, Usuku K, et al,: "Human CD4+Tlymphocytes recognize a highly conserved epitope of HTLV-I env gp 21 restricted by HLADRBl^*0101." Clin.Exp.Immunol.(in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Manns A, Hanchard B, et al.: "HLA class II alleles associated with HTLV-I infection and adult T-cell leukemia/lymphoma in a black population." J.Natl.Cancer,Inst.(in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miura.T,Yamashita M,et al: "Molecular phylogeny of human T-cell leukemia virus tupe I and II of Amerndians in Colombia and Chile" J.Mol.Evol. 44. 76-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sameshima A,Fujiyoshi T,et al: "Demonstration of antibodies against human papillomavirus type 11-E-6 and L2 proteins in patients with recurrent respiratory papillomatosis" Auris Nasus Larynx. 24. 185-191 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kubo K,Fujiyoshi T,et al: "Lack of association of Boma disease virus and human T-cell leukemia virus type-1 infection with psychiatric disorders among Japanese patients" Clin.Diagn.Lab.Immunol. 4. 189-191 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamano Y,Kitze B,et al: "Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP" J.Neuroimmunol. 76. 50-60 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitze B,Usuku K,et al: "Human CD4+Tlymphocytes recongnize a highly conserved epitope of HTLV-1 env gp 21 restricted by HLADRB1^<**>0101" Clin.Exp.immunol. in press. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Manns A,Hanchard B,et al: "HLA class II alleles associated with HTLV-I infection and adult T-cell leukemia/lymphoma in a black population" J.Natl.cancer.Inst. in press. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miura.T, Yamashita M, et al.: "Molecular phylogeny of human T-cell leukemia virus type I and II of Amerndians in Colombia and Chile." J.Mol.Evol. 44. 76-82 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Samehsima A, Fujiyoshi T, et al: "Demonstration of antibodies against human papillomavirus type 11-E-6 and L2 proteinsin patients with recurrent respiratory papillomatosis." Auris Nasus Larynx. 24. 185-191 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kubo K, Fujiyoshi T, et al.: "Lack of association of Borna discase virus and human T-cell leukemia virus type-1 infection with psychiatric disorders among Japanese patients." Clin.Diagn.Lab.Immunol.4. 189-191 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamano Y, Kitze B, et al.: "Preferential recognition of synthetic peptides from HTLV-I-gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP" J.Neuroimmunol.76. 50-60 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitze B, Usuku K, et al.: "Human CD4+Tlymphocytes recognize a Highly conserved epitope of HTLV-1 env gp 21restricted by HLADRB1^*0101" Clin.Exp.Immunol. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Manns A, Hanchard B, et al.: "HLA class II alleles associated with HTLV-I infection and adult T-cell leukemia/lymphoma in a black population." J.Natl.Cancer.Inst.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] L. La Granade. S. Sonoda. W. Miller, E. Pete, P. Rodgers-Johnson, B. Hanchard, B. Cranston, T. Fujiyosji. S. Yashiki, M. Blank, C. J. Gibbs and A. Manns.: "HLA DRB1*DQB1*haplotype in HTLV-I-asssociated familial infective dermatitis may predict development of HAM/TSP." Amer. J. Med. Genet.61. 37-41 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] B. Kitze, K. Usuku, S. Izumo, M. Nakamura, H. Shiraki, N. Ijichi, S. Yashiki, T. Fujiyoshi, S. Sonoda and M. Osame.: "Diversity of the intrathecal antibody synthesis against HTLV-I and its relation to disease." J. Neurol.243. 393-400 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] B. Kitze, K. Usuku, S. Yashiki, S. Ijichi, T. Fujiyoshi, M. Nakamura, S. Izumo, M. Osame, and S. sonoda.: "Intrathecal humoral immune response in HAM/TSP in relation to HLA haplotype analysis." Act. Neurol. Scand. 94. 287-293 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M. Nagai, S. Yashiki, T. Fujiyoshi, C. Fujiyama, B. Kitze, S. Izumo, M. Osame and S. Sonoda.: "Characterization of a unique T-cell clone established from a patient with HAM/TSP which recognized HTLV-I-infected T-cell antigens as well as spinal cord tissue antigens." J. Neuroimmunol.65. 97-106 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Sonoda, T. Fujiyoshi and S. Yashiki.: "Immunogenetics of HTLV-I/II and associated diseases." J. Acq. Immun. Defic. Synd. Hum. R.13 (suppl 1). S119-S123 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Sonoda and T. Fujiyoshi: "HTLV-I infection and HLA." Gann Monograph on Cancer Research Ethnoepidemiology of Cancer (eds. K. Tajima and S. Sonoda) .44. 81-93 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K. Tajima and S. Sonoda.: "Ethnoepidemiology, a new paradigm, for studying cancer risk factors and prevention strategy." Gann Monograph on Cancer Research Ethnoepidemiology of Cancer (eds. K. Tajima and S. Sonoda) .44. 3-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y. Yamano, B. Kitze, S. Yashiki, K. Usuku, T. Fujiyoshi, T. Kaminagayoshi, K. Unoki, S. Izumo, M. Osame and S. Sonoda.: "Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP." J. Neuroimmunol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] K. Kubo. T. Fujiyoshi, M. M. Yokoyama, K. Kamei, J. A. Richt, B. Kitze, S. Herzog, M. Takigawa and S. Sonoda.: "Lack of association of Borna Disease Virus and human T-cell leukemia virus type I infections with psychiatric disorders among Japanese patients." Glin. Diag. Lab. Immunol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] K. Tajima and S. Sonoda (des) .: "Ethnoepidemiology of Cancer, Gann Monograph on Cancer Research No. 44" 日本学会出版センター, 1-223 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 園田俊郎、田島和雄: "HTLV-I、II民族疫学、Molecular Medicine(特集ヒトがんウイルス)33巻" 中山書店, 334-341 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 園田俊郎: "HTLV-I、IIの感染の疫学、免疫応答と発癌の宿主要因(特集 ヒト癌ウイルスによる発癌機構)血液腫瘍科 33巻" 科学評論社, 123-132 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 園田俊郎: "ウイルス感染症 標準微生物学第6版(平松、山西編)" 医学書院, 376-384 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 園田俊郎: "臨床検査 ウイルス 微生物学(竹田、上田、浜田、垣内編)" 医歯薬出版, 682-692 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 園田俊郎: "ウイルス感染症の疫学 微生物学(竹田、上田、浜田、垣内編)" 医歯薬出版, 644-652 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 屋敷伸治、園田俊郎: "レトロウイルス、遅発性ウイルス感染症とその類似疾患(脳と神経科学シリーズ3" メデイカルレビュー社, 12-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Katahira.,S.Yashiki.,T.Fujihoshi et al.: "In vitro induction of cytotoxic T lymphocytes against HLTV-I-infected T-cells from adult T-cell leukemia patients,asymptomatic HTLV-I carriers and serogenative healthy donors." Jpn.J.Cancer Res.86. 21-27 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Yoshida.,S.Yashiki.,T.Oki.,T.Fujiyoshi.,Y.Nagata and S.Sonoda.: "A meternal risk factor for mother-to-child HTLV-I transmission : viral antigen-producities in culture of cells in peripheral blood and breast milk." Jpn.J.Cancer Res.86. 649-654 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] C.Fujiyama.,T.Fujiyoshi.,D.Matsumoto.,H.Tamashiro.,and S.Sonoda.: "Evaluation of commercial HTLV-I test kits by a standard HTLV-I serum panel." WHO Bulletin.74. 515-521 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] C.Fujiyama.,T.Fujiyoshi.,D.Matsumoto.,S.Yashiki.,H.Tamashiro and S.Sonoda.: "Re-evaluation of anti-HTLV-I western blot assay using HTLV-I and HTLV-II serum panel." Clin.Diag.Virol.4. 149-161 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Fujiyoshi.,S.Yashiki.,C.Fujiyama.,et al.: "Ethnic segregation of HTLV-I and HTLV-II carriers among South American native indians." Int.J.Cancer.63. 510-515 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Miyashita.,T.Fujiyoshi.,S.Yashiki.,M.Kuwayama.,C.Fujiyama and S.Sonoda.: "Cloning of HLA-A26 cDNA from Japanese donors possessing "ATL-associated HLA haplotypes"" Tissue Antigens.46. 398-400 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamashita M.,Kitze B.,Miura T.et al.: "LTR sequences of HTLV-I from non-Mashhadi Iranians who immigrated to Germany : its phylogenetic relationship to those from Iranian Mashhadi Jews." AIDS Res Hum Retrovirus.11. 1533-1535 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] L.La Granade.,S.Sonoda.,W.Miller.,E.Pete.,P.Rodgers-Johnson.,et al.: "HLA DRB1*DQB1*haplotype in HTLV-I-associated familial infective dermatitis may predict develrpment of HAM/TSP." Amer.J.Med.Genet.61. 37-41 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Nagai.,S.Yashiki.,T.Fujiyoshi.,et al.: "Characterization of a unique T-cell clone established from a patient with HAM/TSP which recognized HTLV-I-infected T-cells antigens as well as spinal cord tissue antigens." J.Neuroimmunol.(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] S.Sonoda.,T.Fujiyoshi.,and S.Yashiki.: "Immunogenetics of HTLV-I/II and associated diseases." J.Acquir.Immune Defic.Syndu.Hum.Retrovirol.(in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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