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Etiology of Lung Cancer among Women in Northern Thailand

Research Project

Project/Area Number 07042012
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research Field 広領域
Research InstitutionResearch Institute for Clinical Oncology, Saitama Cancer Center

Principal Investigator

NAKACHI Kei  Saitama Cancer Center Research Institute, Epidemiology, Vice-head, 研究所疫学部, 副部長 (00142117)

Co-Investigator(Kenkyū-buntansha) FUJIKI Hirota  Saitama Cancer Center Research Institute, Director, 研究所, 所長 (60124426)
SHIMIZU Hiroyuki  Gifu University, School of Medicine, Public Health, Professor, 医学部, 教授 (90073139)
SONE Yoshiaki  Osaka City University, Faculty of Science of Living, Assistant Professor, 生活科学部, 助教授 (60145802)
TAKAHASHI Takeshi  Aichi Cancer Center Research Institute, Ultrastructure, Head, 研究所超微形体態学部, 部長 (50231395)
TSUCHIYA Eiji  Saitama Cancer Center Research Institute, Pathology, Head, 研究所病理部, 部長 (00072314)
MAITREE Sutt  チェンマイ大学, 医学部, 教授
SUTTAJIT Mai  チェンマイ大学, 医学部, 教授
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 1997: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1996: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1995: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsLung cancer / Northern Thailand / タイ北部 / 女性
Research Abstract

Nothern part of Thailand, in particular Chiang Mai Province, has been known to show very high incidence rates of lung cancer, which yearly increase, on the basis of the cancer registry data, i.e., the age-adjusted rates were 34.5 and 26.9 in 1985 for men and women, respectively ; those increased to 47.7 and 40.1 in 1992. Particularly, recent increase of lung cancer incidence in Chiang Mai women aged over 55 years is a serious problem to be solved along with the very high incidence of lung cancer as a whole. Only few studies have been so far carried out to find the causes of lung cancer and thus establish preventive measures against lung cancer.
We started a research project on the etiology of lung cancer in collaboration with the faculty of medicine, Chaing Mai University, since 1995. This research project entailed the following three approaches :
1) a comparative study of general women living in high and low incidence areas of lung cancer in Chiang Mai, 2) a case-control study at a hosp … More ital (Maharaj Nakorn Chiang Mai Hospital) of the faculty of medicine, Chiang Mai University, which is the largest hospital in Chiang Mai Province, and 3) pathological and molecular biological studies on lung cancer specimens obtained at the Maharaj Nakorn Chiang Mai Hospital.
The first approach includes a epidemiological survey on their lifestyle by interviewing, nutritional survey on duplicated meals, serological analysis of their serum samples, mutagenicity assay of urine samples, identification of bacteria and fungi in sputum and those floating in the air indoor their houses. We surveyed 57 and 59 women aged at 50-74 years living at Sarapee (high incidence) and Chomtong (low incidence ; about the one-fourth of Sarapee's rate) districts in 1995 and 1996, respectively. Lower rate, 28.1%, of current smokers was observed in Sarapee, compared with 61.0% in Chomtong district.This result strongly implies that cigarette smoking alone can not explain the remarkable difference in lung cancer incidence between these districts. Althoug intake frequency and amount of green & yellow vegetables and fruits was less in Sarapee than that in Chomtong, the most outstanding difference between the districts was prevalence of benigh respiratory diseases : 43.7% in Sarapee experienced benigh respiratory diseases such as clonical bronchitis and COPD in contrast to 13.6% in Chomtong. Those female smokers in Sarapee who experienced benigh respiratory diseases showed very high serum IgE levels over 1000 U/ml, indicating long-term exposure of the lung to environmental substances. Furthermore, some types of bacteria, in particular M.canis, were specifically found in the air inside the houses in Sarapee.
Along with the approaches 2) and 3), we isolated and cultured these bacteria for subsequent animal experiments to examine the tumor promotion activity of the bacteria. Less

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Yoshiaki Sone: "Comparison of diets among elderly female residents in two suburban districts in Chiang Mai Province,Thailand,in dry season-survey on high-and low-risk districts of lung cancer incidence" Appl Human Sci,. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sone, Y., Sakamoto, N., Suga, K., Imai, K., Nakachi, K., Sonclin, P., Sonclin, A., Lipigomgoson, S., Limtrakul, P.and Suttajit, M.: "Comparison of diets among elderly female residents in two suburban district in Chiang Mai Province, Thailand, in dry season-survey on high-and low-risk districts of lung cancer incidence-" Appl Human Sci. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiaki Sone: "Comparison of diets among elderly female residents in two suburban districts in Chiang Mai Province,Thailand,in dry season-survey on high-and low-risk districts of lung cancer incidence" Appl Human Sci,. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Nakachi,et al.: "Some evidences of molecular epidemiology in Japan" J.Epidemiology. 6. S125-S129 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Nagatake,T.Takahashi,et al.: "Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancer" Cancer Res.56. 2718-2720 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Fujiki,et al.: "Naturally derived tumor promoters and inhibitors of carcinogenesis" J.Toxico-Toxin Reviews. 15(2). 129-156 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Nakachi,K.Imai: "Ethnoepidemiology of Cancer (Gann Monogr.Cancer Res.No.44)" Japan Scientific Societies Press, 223 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] E.Sueoka H.Fujiki,et al: "Activation of protein kinase C by mycobacterial cord factor,trehalose 6-monomycolate,resulting in tumor necrosis foctor-α release in mouse lung tissue" Jpn.J.Cancer Res.86. 749-755 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Nakachi,et al: "Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinoma of the lung by grades of differentiation" Carcinogenesis. 16. 2209-2213 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E.Sueoka H.Fujiki,et al.: "Proceedings of International Symposium on Ciguatera and Marine Natural Products" Asian-Pacific Research Foundation, 183-195 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Suganuma H.Fujiki,et al.: "Proceedings of International Symposium on Ciguatera and Marine Natural Products" Asian-Pacific Research Foundation, 217-226 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Fujiki M.Suganuma,et al.: "Carcinogenesis of microcystins" CRC Press, 203-232 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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