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Molecular studies on incubation behavior and the application

Research Project

Project/Area Number 07044190
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Applied animal science
Research InstitutionNagoya University

Principal Investigator

SHIMADA Kiyoshi  Nagoya University School of Agricultural Professor Science, 農学部, 教授 (40065579)

Co-Investigator(Kenkyū-buntansha) SAITO Noboru  Nagoya University School of Agricultural Science Assistant Professor, 農学部, 助手 (40211924)
OHKUBO Takeshi  Mie University Center of Mol.Biol.and Genetics Assistant Professor, 遺伝子実験施設, 助手 (70233070)
KUWAYAMA Takehito  Tokyo Agricultural University Department of Zootechnical Sci.Lecturer, 農学部, 講師 (40215124)
KATO Yukio  Gumma University Institute of Mol.Cell.Reg.Professor, 生体調節研, 助教授
M.EL Halawan  ミネソタ大学, 農学部, 教授
DAVID Zadowo  マギル大学, 農学部, 助教授
PROUDMAN Jo  米国農務省, 畜産学, 研究員
ZADWORNY Da  マギル大学, 農学部, 助教授
SHARP Peter  ロスリン研究所, 発生・生殖部門, 教授
河本 馨  東京大学, 農学部, 教授 (30011894)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 1997: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1995: ¥4,400,000 (Direct Cost: ¥4,400,000)
Keywordsprolactin / incubation behavior / chicken / mRNA / prolactin receptor / pituitary / hypothalamus / PRL mRNA / VIP Receptor / GnRH / antisense / PRLmRNA / GHmRNA / VIP / GRF / cyclic AMP / PRL-Rc / recombinant PRL
Research Abstract

Now commercial White Leghorn strain chicken dose not express incubation behavior, but Japanese native strain chicken and turkey hens still express incubation behavior. Therefore, in these birds, the incubation behavior lowers productivity of meat and egg laying, causing a lot of economic loss in poulty industries. Therefore, the poupose of present study is to reveal molecular mechanism of the incubation behavior and to establish the application for the removal of incubation behavior of these birds.
Turkey and Gifu-jidori hens still express incubation behavior. During the reproductive cycle in these birds, levels of plasma prolactin (PRL) and pituitary PRL mRNA increased during the incubation period but these levels were low in the laying period. These results suggest that PRL may regulate induction and maintaining of incubation behavior.
Using perifusion culture of the pituitary and cell culture of pituitary cells, we demonstrated that VIP induces PRL synthesis and release in the pituita … More ry gland via cAMP cascade. We cloned chicken VIP receptor mRNA.
There were no significant difference in the distribution of brain PRL receptor mRNA between chabohen displaying expression of incubation behavior and White Leghorn hens without expression of incubation behavior. In addition, during reproductive cycle in chabo hen the levels of brain PRL receptor mRNA did not change.
Effects of remobal of newly hatched chicks on incubation behavior were studied in the chabo hens. Those hens whose chicks were removed from the nest for 24 hr displayd again incubation behavior but those hens whose chicks were removed from the nest for 72 hr did not show incubation behavior again. The plasma levels of PRL decreased in all hens whose chicks were removed from the nest for 24 and 72hr. This results suggested that other factor may regulate the maintain of incubation behavior.
The administrations of VIP antibody into turkey and chicken hens markedly reduced plasma levels of PRL and inhibited incubation behavior. Less

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (119 results)

All Other

All Publications (119 results)

  • [Publications] Kansaku N., Shimada K., Saito N.: "Regionalized gene expression of prolactin and growth hormone in the chicken anterior pituitary gland." Gen.Comp.Endocrinol.99. 60-68 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ieda T., Saito N., Ono T., Shimada K.: "Effects of presence of an egg and calcium deposiuon in the shell gland on levels of messenger ribonucleic acid of CaBP-D28K and of vitamin Dd3 receptor in the chell gland of the laving hen." Gen.Comp.Endocrinol.99. 145-151 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato M., Shimada K., Saito N., Noda K., Ohta M.,: "Expression of P450I/α hydroxylase and P450aromatase genes in isolated granulosa,theca interna and theca externa layers of the chicken ovarian follicles during follicular growth" Biol.Reprod.52. 405-410 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka M.Toma Y.Ohkubo T., Sudo S., Nakashima K.: "Sequence of the flounder(Paralichthys olivaceus)growth hormone-encoding gene and its promoter region." Gene.165. 321-322 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato Y., Gen K., Chung H.-O., Kato T.: "Gonadotropins:Basic view and gene expression." Korean J.Animal Reprod.19. 15-34 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadokoro N., Koibuchi N., Ohtake H., Kawatsu T., Kato Y., Yamaoka S., Kumasaka T.: "Expression of proalctin gene in human decidua during pregnancy detected by in situ hybridization histochemistry." Endocrinol.J.42. 537-543 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadokoro N., Koibuchi N., Ohatake H., Kawatsu T., Tanaka S., Kato Y.Yamaoka S., Kumasaka T.: "Localization of prolactin and its receptor messenger RNA in the human decidua." Experimentia. 12. 1216-1219 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chung HO.Tomizawa K.Kato T.Wakabayashi K., Kato Y.: "Increased thermo-stability of rat prolactin after replacing glutamic acid at position 118 by lysine." Zool.Sci.13. 915-919 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chung HO., Kato T., Kato Y.: "Molecular cloning of c-jun and c-foc cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing hormone stimulation" Mol.& Cell.Endocrinol.119. 75-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu H., Ohtani K., Kato Y., Tanaka Y., Mori M.: "Estrogen increases hypothalamic neuropeptide Y(NPY)mRNA expression in ovariectomized obese rat." Neurosci.Lett.204. 81-84 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K., Koichi H.Kato Y.Mori M.: "Genomic organization and promoter tunction of the human thyrotropin-reteasing hormone receprot gene." J.Biol.Chem.271. 22183-22188 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato Y., Maruyama O., Chung HO., Tomizawa K., Kato T.: "Amino acids in highly conserved regions near the C-terminus of rat prolactin(PRL)play critical roles similar to those in binding of human GH to the PRL receptor." Biochem.& Biophys.Res Com.222. 547-552 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagase M., Todo T., Gen K., Kato Y., Young G., Adachi S., Yamauchi K: "Motecutar ctoning and sequence anatysis of the cDNAs encoding the glycoprotein hormone and α-and gonadotropin IIβ-subunits,and their expression in the pituaitary of teh Iapanese eel Anguilla japonica" J.Mol.Endoctinol.16. 171-181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ma E, Milewski N., Grossmann R., Ivell R., Kato Y., Ellendorff F.: "Expression of GH,TSHβ geneduring fetal pituitary development in teh pig." Exp.Clin.Endocrinol.Diabat.104. 464-472 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ikuyama S., Ohe H., Sakai Y., Naka gaki H., Fukushima T., Kato Y., Mo rohashi K.-K., Takayanagi R., Nawata H.: "Folliccle stimulating hormone-β-subunit gene is expressed in parallet with a transcnption factor Ad5BP/SF-1 in human pituitary adenomas." Clin.Endocrinol.45. 187-193 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ogawa H., Kuwayama T., Tanaka T.: "Rapid growth phase of ovum in the guniea fowl." Jpn.Poult.Sci.33. 300-304 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ogawa H., Kuwayama T., Tanaka T.: "The timing of ovulation after oviposition and the time spent by the ovum in each portion of oviduct in the guniea fowl." Jpn.Poult.Sci.33. 118-122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuwayama T., Ogawa H., Munechika I., Kono T., Ichinoe K.: "Crowing characteristics of jungle fowl,Japanese native breeds and white leghom breed of chiken." Jpn.Poult.Sci.33. 89-95 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakaguchi K.Tanaka M.Ohkubo T.Doh-ura K.Fujikawa T.Sudo S.Nakashima K: "Induction of brain prolactin receptor long-torm mRNA expression and maternal behavior in pup-contacted male rats:promotion by prolactin administration and suppression by female contact" Neuroendocrinol.63. 559-568 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohkubo T., Araki M., Tanaka M., Sudo S., Nakashima K.: "Molecular cloning and characterization of the yellowtail GH gene and its promoter:a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites." J.Mol.Endoctinol.16. 63-72 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka M., Hayashida Y., Sakaguchi K., Ohkubo T., Wakita M., Hoshino S., Nakashima K: "Growth hormone-independent expression of insulin-like growth factor I messenger ribonucleic acid in extrahepatic tisues of the chicken." Endocrinology.137. 30-34 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawant, Shimada K., Yoshida K., Saito N.: "Effects of aromatase inhibitor on sex differentiation and levels of P45017α and P450arom messenger ribonucleic acid of gonads in chicken embryos." Gene.Comp.Endocrinol.102. 241-246 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuhn E.R., Shimada K., Ohkubo T., Vleurick L.M., Berghman L.R., Darras V.M.: "Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo." Gen.Comp.Endocrinol.103. 349-358 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sechman A., Shimada K., Saito N., Ieda T., Ono T.: "Tmodothyronine(13)enhances the stimulatory effect of 1,25-dihydroxyvitamine D3 on calbindin-D28K mRNA expression in the kidney and intestine but not in cerebellum of the chick" A.J.A.S.,. 9. 37-44 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshida K., Shimada K., and Saito N.: "Expression of P45017α hydroxyiase and P450 aromatase genes in the chicken gonad before and after sexual differentiation." Gen.Comp.Endoctinol.,. 102. 23-240 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murayama T., Kawashima M., Takahashi T., Yasuoka T., Kuwayama T., Tanaka K: "Direst action of melatonin on hen ovarian granulosa cells to lower responsiveness to luteinizing hormone." Proc.Soc.Exp.Biol.& Med.215. 386-392 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuwyama T., Shimada K., Wada M., Tanaka K.: "Increase in plasma luteinizing hormoneand estradiol-17α concentraions following an injection of luteinizing hormonr-releasing hormone in incubating and brooding Gifujidori hens." Jpn.Poult.Sci.34. 404-409 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kobayashi M., Kato Y., Yoshiura Y., Aida K.: "Molecular cloning of cDNAs encoding two tyoes of pituaitry gonadotropin α-subunit from the goldfish,Carassius auratus." Gen.Comp.endocrinol.105. 372-378 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inaba T., Mori J., Ohmura M., Tomizawa K., Kato Y., Ihara T., Sato I.and Ueda S.: "Baculovirus-insect cell production of bioactive porcine FSH." Theeriogenology. 47. 491-499 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshida Y., Kobayashi M., Kato Y.and Aida K.: "Molecular cloning of cDNAs encoding two types of pituitary gonadotropin β-subunit from the gold fish,Carassius auratus." Gen.Comp.Endocrinol.105. 379-389 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Granz S., Ellendorff F., Grossmann R., Ivell R., Kato Y., Mulbauer e and Flsaesser F: "Ontogeny of growth hormone and LHβ-,FSHβ and α-subunit mRNA concentraions in the porcine fetal neonatal anterior pituitary." J.Neuroendocrinol.9. 439-449 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato Y.Tomizawa K.Kato T.: "Enhancement of the receptor binding and Nb2 proliferation activities of rat prolactin by site-directed mutagenesis." Zool.Sci.14. 147-152 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sudo S., Fujikawa T., Nagakura T., Ohkubo T., Sakaguchi K., Tanaka M., Nakashima K., Takahashi T.: "Structures of mollusc shell framework proteins." Nature. 387. 563-564 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A binawanto, Zhang C., Saito N., Shimada K.: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken." J.Exp.Zool.280. 65-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kansaku N., Shimada K., Saito N., Hidaka H.: "Effects of protein kinase A inhibitor(H-89)on VIP-and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland." Comp.Biochem.Physiol.119. 89-95 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohkubo T., Tanaka M., Nakashima K.Talbot R.T and Sharp P.J.: "Prolactin receptor gene expression in the brain and peripheral tissues in broody and non-broody breeds of domestic hen." Gen.Comp.Endocrinol.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Zhang C., Shimada K., Saito N., Knsaku N.: "Expression of messenger ribonucleic acids of luteinizing hormone and follicle stimulating hormone receptors in granulosa and theca layers of chicken preovulatory follicles." Gen.Comp.Endocrinol.105. 402-409 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimada K., Saito N.: "Possible AVT involvement in regulation of body water balance during the incubation period in the chabo hen." Jpn.Poult.Sci.34. 169-174 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawanto.Shimada K., Saito N.: "Sex-reversal effects of non-steroidal aromatase inhibitor on aromatase(P450arom)nRNA expression in adult chicken gonads." Jpn.Poult.Sci.34. 158-328 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawanto, Shimada K., Saito N.Sugishima T., Shiokawa E.: "Effects of aromatase inhibitor on sex differentiation and levels of P450c17 and P450 arom mRNA of gonads in broiler embryos and broiler chickens." Jpn.Poult.Sci.34. 318-328 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tarada O., Shimada K., Saito N.: "Effect of oestradiol replacement in ovariectomized chickens on pituaitary LH concentrations and concentrations of mRNAs encoding LH β and α subunits." J.reprod.Fert.111. 59-64 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 斉藤 昇: "“新しい卵巣ホルモン"の産生と作用" 日本家禽学会誌. 34. 1-8 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumoto K., Ieda T., Saito N.Ono T., Shimada K.: "Rele of retinoic acid in regulation of mRNA expression of CaBP-D28K in cerebellum of the chicken" Comp.Biochem.Physiol.(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito N., Shimada K.: "Perspectives in Avian Endoctinology" Journal of Endocrinology Ltd., 7 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimada K.and Kanasaku N.: "Advances in Compretive Endoctinology" Monduzzi Editore S.p.A., 5 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimada K.and Saito N.: "Reproductive Biology Update-novel tools for assessment of enviromental toxicity" Shoukadoh Booksellers Company, 9 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kansaku N., Shimada K., Saito N.: "Regionalized gene expression of prolactin and growth hormone in the chicken anterior pituitary gland." Gen.Comp.Endocrinol.99. 60-68 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ieda T., Saito N., Ono T., Shimada K.: "Effects of presence of an egg and calcium deposition in the shell gland on levels of messenger ribonucleic acid of CaBP-D28K and of vitamin D3 receptor in the chell gland of the laying hen." Gen.Comp.Endocrinol.99. 145-151 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato M., Shimada K., Saito N., Noda K., Ohta M.: "Expression of P45017alpha hydroxylase and P450aromatase genes in isolated granulosa, theca interna cnd theca externa layrs of the chicken ovarian follicles during follicular growth." Biol.Reprod.52. 405-410 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Karo Y., Gen K., Chung H.-O., Kato T.: "Gonadotropins : Basic view and gene expression." Korean J.Animal Reprod.19. 15-34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadokoro N., Koibuchi N., Ohtake H., Kawatsu T., Kato Y., Ymaoka S., Kumasaka T.: "Expression of proalctin gene in human decidua during pregnancy detected by in situ hybridization histochemistry." Endocrinol J.42. 537-543 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tadokoro N., Koibuchi N., Ohtake H., Kawatsu T., Tanaka S., Kato Y., Ymaoka S., Kumasaka T.: "Localization of prolactin and its receptor messenger RNA in the human decidua." Experimentia. 12. 1216-1219 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka M.Toma Y.Ohkubo T.Sudo S., Nakashima K.: "Sequence of the folunder (Paralichthys olivaceus) growth hormone-encoding gene and its promoter region." Gene. 165. 321-322 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawant, Shimada K., Yoshida K.and Saito N.: "Effects of aromatase inhibitor on sex differentiation and levels of P45017alpha and P450arom messenger ribonucleic acid of gonads in chicken embryos." Gene.Comp.Endocrinol.102. 241-246 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuhn E.R., Shimada K., Ohkubo T., Vleurick L.M., Berghman L.R., Darras V.M.: "Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo." Gen.Comp.Endocrinol.103. 349-358 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sehman A., Shimada K., Saito N., Ieda T., Ono T.: "Triodothyronine (T3) enhances the stimulatory effect of 1,25-dihydroxyvitamine D3 on calbindin-D28K mRNA expression in the kidney and intestine but not in cerebellum of the chick." A.J.A.S.9. 37-44 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yohida K., Shimada K., Saito N.: "Expression of P45017alpha hydroxylase and P450 aromatase genes in the chicken gonad before and after sexual differentiation." Gen.Comp.Endocrinol.102. 23-240 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chung HO.Tomizawa K.Kato T.Wakabayashi K.Kato Y.: "Increased thermo-stability of rat prolactin after replactin after replacing glutamic acid at poisition 118 by lysine." Zool.Sci.13. 915-919 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Chung HO.Kato T., Kato Y.: "Melecular cloning of c-jun and c-fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing hormone stimulation" Mol.& Cell.Endocrinol.119. 75-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu H., Ohtani K., Kato Y., Tanaka Y., Mon M.: "Estrogen increases hypothalamic neuropeptide Y (NPY) mRNA expression in ovariectomized obese rat." Neuroscience Lett.204. 81-84 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki T., Yamada M., Satoh T., Konaka S., Ren Y., Hashimoto K.: "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene." J.Bilo.Chem.271. 22183-22188 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato Y., Maruyama O., Chung HO., Tomizawa K., Kato T.: "Amino acids in highly conserved regions near the C-terminus of rat prolactin (PRL) play critical roles similar to those in binding of human GH to the PRL receptor." Biochem Bilphys.Res.Com.222. 547-552 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nagase M., Todo T., Gen K., Kato Y., Young G., Adachi S., Yamauchi K.: "Molecular cloning and sequence analysisi of the cDNAs encoding the glycoprotein hormone a- and gonadotropin IIb-subunits, and their expression in the pituaitary of the Japanese eel, Anguilla japonica." J.Mol.Endocrinol.16. 171-181 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ma E., Milewski N., Grossmann R., Ivell R., Kato Y., Ellendorff F.: "Expression of GH,TSHb and FSHb geneduring fetal pituitary development in teh pig." Exp.Clin.Endocrinol.Diab.104. 464-472 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ikuyama S., Ohe H., Sakai Y., Nakagaki H., Fukushima T., Kato Y., Morohashi K-K., Takayanagi R., Nawata H.: "folliccle stimulating hormone-b-subunit gene is expressed in parallel with a transcription factor Ad4BP/SF-1 in human pituitary adenomas." Clin.Endocrinol.45. 187-193 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ogawa H., Kuwayama T., Tanaka T.: "Rapid growth phase of ovum in the guniea fowl." Jpn.Poult.Sci.33. 300-304 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ogawa H., Kuwayama T., Tanaka T.: "The timing of ovulation after oviposition and the time spent by the ovum in each portion of oviduct in the guniea fowl." Jpn.Poult.Sci.33. 118-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuwayama T., Ogawa H., Munechika I., Kono T., Ichinoe K.: "Crowing characteristics of jungle fowl, Japanese native breeds and white leghorn breed of chiken." Jpn.Poult.Sci.33. 89-95 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakaguchi K.Tanaka M.Ohkubo T.Doh-ura K.Fujikawa T.Sudo S., Nakashima K.: "Induction of brain prolactin receptor long-form mRNA expression and maternal behavior in pup-contacted male rats : promotion by prolactin administration and suppression by female contact." Neuroendocrinology. 63. 559-568 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohkubo T.Araki M.Tanaka M.Sudo S., Nakashima K.: "Molecular cloning and characterization of the yellowtail GH gene and its promoter. a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites." J.Mol.Endocrinol.16. 63-72 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka M.Hayashida Y.Sakaguchi K.Ohkubo T.Wakita M.Hoshino S., Nakashima K.: "Growth hormone-independent expression of insulin-like growth factor I messenger rebonucleic acid in extrahepatic tissues of the chicken." Endocrinology. 137. 30-34 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kobayashi M., Kato Y., Yoshiura Y., Aida K.: "Molecular cloning of cDNAs encoding two tyoes of pituaitry gonadotropin asubunit from the goldfish, Carassius auratus." Gen.Comp.Endocrinol.105. 372-378 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inaba T., Mori J., Ohmura M., Tomizawa K., Kato Y., Ihara T., Sato I., Ueda S.: "Bacculovirus-insect cell production of bioactive porcine FSH." Theeriogenology. 47. 491-499 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshida Y., Kobayashi M., Kato Y., Aida K.: "Molecular cloning of cDNAs encoding two types of pituitary gonadotropin b-subunit from the gold fish, Carassius auratus." Gen.Comp.Endocrinol.105. 379-389 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Granz S., Ellendorff F., Grossmann R., Ivell R., Kato Y., Mulbauer E., Elsaesser F.: "Ontogeny of growth hormone and LHbeta-, FSHbeta and alpha-subunit mRNA concentraions in the porcine fetal neonatal anterior pituitary." J.Neuroendocrinol.9. 439-449 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato Y.Tomizawa K., Kato T.: "Enhancement of the receptor binding and Nb2 proliferation activities of rat prolactin by site-directed mutagenesis." Zool.Sci.14. 147-152 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Murayama T.Kawashima M.Takahashi T.Yasuoka T.Kuwayama T., Tanaka K.: "Direct action of melatonin on hen ovarian granulosa cells to lower responsiveness toluteinizing hormone." Proc.Soc.Esp.Biol.& Med.215. 386-392 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuwyama T., Shimada K., Wada M., Tanaka K.: "Increase in plasma luteinizing hormoneand estradiol-17a concentraions following aninjection of luteinizing hormonr-releasing hormone in incubating and brooding Gifujidori hens." Jpn.Poult.Sci.34. 404-409 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sudo S.Fujikawa T.Nagakura T.Ohkubo T.Sakaguchi K.Tanaka M.Nakashima K.Takahashi T.: "Structures of mollusc shell framework proteins." Nature. 387. 563-564 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohkubo T., Tanaka M., Nakashima K., Talbot R.T., Sharp P.J.: "Prolactin receptor gene expression in the brain and peripheral tissues in broody and non-broody of domestic hen." Gen.Comp.Endocrinol.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Zhang C., Shimada K., Saito N., Kansaku N.: "Expression of messenger ribonucleic acids of luteinizing hormone and follicle stimulating hormone receptors in granulosa and theca layrs of chicken preovulatory follicles." Gen.Comp.Endocrinol.105. 402-409 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimada K., Saito N.: "Possible A VT involvement in regulation of body water balance during the incubation oeriod in the chabo hen." Jpn.Poult.Sci.34. 169-174 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawanto, Shimada K., Saito N.: "Sex-reversal effects on non-steroidal aromatase inhibitor on aromatase (P450arom) mRNA expression in adult chicken gonads." Jpn.Poult.Sci.34. 158-168 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawanto, Shimada K., Saito N.Sugishima T., Shiokawa E.: "Effects of aromatase inhibitor on sex differentiation and levels of P450c17 and P450 arom mRNA of gonads in broiler embryos and broiler chickens." Jpn.Poult.Sci.34. 318-328 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Terada O., Shimada K., Saito N.: "Effects of oestradiol replacement in ovariectomized chickens on pituaitary LH concentrations and concentrations of mRNAs encoding LH beta and alpha subunits." J.Reprod.Fert.111. 59-64 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Abinawanto, Zhang C., Saito N., Shimada K.: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken." J.Exp.Zool.280. 65-72 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kansaku N., Shimada K., Saito N., Hidaka H.: "Effects of protein kinase A inhibitor (H-89) on VIP-and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pituitary gland." Comp.Biochem.Physiol.119. 89-95 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumoto K., Ieda T., Saito N., Ono T., Shimada K.: "Role of retinoic acid in regulation of mRNA expression of CaBp-D28K in cerebellum of the chicken" Comp.Biochem.Physiol.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Zhang C., Shimada K., Saito N.and Kansaku N.: "Expression of messenger ribonucleic acids of luteinizing hormone and follicle stimulating hormone receptors in granulosa and theca layers of chicken preovulatory follicles." Gen.Comp.Endocrinol.105. 402-409 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimada K.and Saito N.: "Possible AVT involvement in regulation of body water balance during the incubation period in the chabo hen." Jpn.Poult.Sci.34. 169-174 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abinawanto, Shimada K.and Saito N.: "Sex-reversal effects of non-steroidal aromatase inhibitor on a aromatase(P450arom)mRNA expression in adult chicken gonads." Jpn.Poult.Sci.34. 158-168 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abinawanto, Shimada K., Saito N.Sugishima T.and Shiokawa E.: "Effects of aromatase inhibitor on sex differetiation and levels of P450c17 and P450 arom mRNA of gonads in broiler embryos and broiler chickens." Jpn.Poult.Sci.34. 318-328 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Terada O., Shimada K.and Saito N.: "Effect of oestradiol replacement in ovariectomized chickens on pituaitary LH concentrations and concentrations of mRNAs encoding LH β and α subunits." J.Reprod.Fert.111. 59-64 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 斉藤 昇: "″新しい卵巣ホルモン″の産生と作用" 日本家舎学会誌. 34. 1-8 (1997)

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      1997 Annual Research Report
  • [Publications] Abinawanto, Zhang C., Saito N., and Shimada K.: "Identification of sperm bearing female-specific chromosome in the sex-reversed chicken." J.Exp.Zool.280. 65-72 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kansaku N., Shimada K, Saito N., and Hidaka H.: "Effects of protein kinase Ainhibitor(H-89)on VIP-and GRF-induced release and mRNA expression of prolactin and growth hormone in the chicken pitutary gland." Comp.Biochem.Physiol.(in press). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto K., Ieda T., Saito N.Ono T and Shimada K.: "Role of retinoic acid in regulation of mRNA expression of CaBP-D28K in cerebellum of the chicken" Comp.Biochem.Physiol.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito N.and Shimada K.: "Perspectives in Avian Endocrinology" Journal of Endocrinology Ltd., 7 (1997)

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      1997 Annual Research Report
  • [Publications] Sechman A.,Shimada K.,Saito N.,Ieda T.,and Ono T.: "Triiodothyronine(T3)enhances the stimulatory effect of 1,25-dihydroxyvitamin D3 on calbindin-D28K mRNA expression in the kidney and…" Asia-Austrasian J.Animal Sci.9. 37-44 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshida K.,Shimada K.,and Saito N: "Expression of P45017α hydroxylase and P450aromatase genes in the chicken gonad before and after sexual differentiation." Gen.Comp.Endocrinol.102. 233-240 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Abinawanto,Shimada K.,Yoshida K.,and Saito N.: "Effects of aromatase inhibitor on sex differentiation and levels of P45017α and P450arom messenger ribonucleic acid…" Gen.Comp.Endocrinol.102. 241-246 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Chaturvedi,C.M.,Zheng,Z.,Shimada,K.,Cornett,L.E.and Koike,T.I.: "Changes in poly(A)tail length of arginine vasotocin messenger ribonucleic acid in the hypothalamus of water-deprived chickens." Gen.Comp.Endocrinol.103. 316-322 (1996)

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      1996 Annual Research Report
  • [Publications] Kuhn,E.R.,Shimada,K.,Ohkubo,T.,Vleurick,L.M.,Berghman,L.R.and Darras,V.M.: "Influence of recombinant chicken prolactin on thyroid hormone metabolism in the chick embryo." Gen.Comp.Endocrinol.103. 349-358 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 斉藤昇: ""新しい卵巣ホルモン"の産生と作用" 日本家禽学会誌. 34. 1-8 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Zhang C.,Shimada K.,Saito N.,and Kansaku N.: "Expression of messenger ribonucleic acids of luteinizing hormone and follicle stimulating hormone receptors in granulosa and theca layers of …" Gen.Comp.Endocrinol.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimada K.and Saito N.: "Possible AVT involvement in regulation of body water balance during the incubation period in the chabo hen." Jpn.Poult.Sci.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Abinawant,Shimada K.,Saito N.Sugishima T.and Shiokawa E.: "Effects of aromatase inhibitor on sex differentiation and levels of P450c17 and P450arom mRNA of gonads in broilerr embryos and broiler chickens" Jpn.Poult.Sci.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hertelendy,F.,Shimada,K.,Toth,M.,Molnar,M.and Tanaka,K.: "Advances in Organ Biology" JAI Press Inc., 29 (1996)

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      1996 Annual Research Report
  • [Publications] Naito, K. et al.: "Association of p34cdc2 and cyclin B1 during meiotic maturation in porcine oocytes." Dev. Biol.168. 627-634 (1995)

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      1995 Annual Research Report
  • [Publications] Kato, M., Shimada, K., Saito, N., Noda, K. and Ohta, M.: "Expression of P450DI_<17α-hydroxylase> and P450_<aromatase> genes in isolated granulosa, theca interna, and theca externa layers…" Biol. Reprod.52. 405-410 (1995)

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      1995 Annual Research Report
  • [Publications] Abinawanto, Shimada, K., Yoshida, K. and Saito, N.: "Sex reversal and gene expression of steroidgenic enzymes in the chiken." Tokai Journal of Animal Production. 5(1). 75-89 (1995)

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      1995 Annual Research Report
  • [Publications] 幸村真吾,加藤真澄,島田清司,齊藤昇,野田賢治,関親生: "ニワトリの排卵周期における卵巣ステロイド合成酵素mRNA量の変動" 東海畜産学会報. 5(1). 90-93 (1995)

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      1995 Annual Research Report
  • [Publications] Kansaku, N, Shimada, K. and Saito, N.: "Regionalized gene expressin of prolactin and growth hormore in the chiken anterior pituitary gland." Gen. Comp. Endocrinol.99. 60-68 (1995)

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      1995 Annual Research Report
  • [Publications] Ieda, T., Saito, N.,Ono, T. and Shimada, K.: "Effects of presence of an egg and calcium deposition in the shell gland on levels of messenger ribonucleic acid of CaBP_<-28K> and…" Gen. Comp. Endocrinol.99. 145-151 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sechman, A., Shimada, K., Saito, N., Ieda, T. and Ono, T.: "Triiodothyronine (T_3) enhnces the stimulatory effect of 1,25-dihydroxyvitamin D_3 on calbindin-D_<28K> mRNA expressin …" Asian-Australasian Journal of Animal Sciences. 9. 37-44 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Abinawanto, Shimada, K., Yoshida, K. and Saito, N.: "Effects of aromatase inhibitor on sex differentiation and levels of P450_<17a> and P450_<arom> messenger ribonucleic acid of …" Gen. Comp. Endocrinol.(1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida, K., Shimada, K. and Saito, N.: "Expression of P450_<17α-hydroxylase> and P450_<aromatase> genes in the chiken gonad before and after sexual differentiation." Gen. Comp. Endocrinol.(accepted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 島田清司,齊藤昇: "日本学術振興会" 日本学術振興会, 6 (1995)

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      1995 Annual Research Report
  • [Publications] 島田清司: "新畜産学大辞典" 養賢堂, 8 (1995)

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      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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