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Optical Analysis of Distributed Processing in Neural Systems

Research Project

Project/Area Number 07044231
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field 神経・脳内生理学
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAMINO Kohtaro  Tokyo Medical and Dental University, School of Medicine, Professor, 医学部, 教授 (40025630)

Co-Investigator(Kenkyū-buntansha) ソーツバージ ブライアン  ペンシルバニア大学, 医学部(米国), 教授
コーエン ローレンスB  エール大学, 医学部(米国), 教授
SATO Katsushige  Tokyo Medical and Dental University, School of Medicine, Research Associate, 医学部, 助手 (80291342)
MOMOSE-SATO Yoko  Tokyo Medical and Dental University, School of Medicine, Research Associate, 医学部, 助手 (70251501)
COHEN Lawrence B.  Yale University, School of Medicine, Professor
SALZBERG Brian M.  University of Pennsylvania, School of Medicine, Professor
コーエン ローレンスB.  エール大学, 医学部・(米国), 教授
SALZBERG Bri  ペンシルバニア大学(米国), 医学部, 教授
COHEN Lawren  エール大学(米国), 医学部, 教授
廣田 秋彦  島根医科大学, 医学部, 教授 (50156717)
SAIZBERG Bri  ペンシルバニア大学(米国), 医学部, 教授
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1997: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1996: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1995: ¥4,300,000 (Direct Cost: ¥4,300,000)
Keywordscentral nervous system / distributed system / optical recording / brainstem / spinal cord / Aplysia / enteric plexus / hypothalamus / 腸管神経叢 / 神経系 / 分散処理システム / 光学的測定 / 脳幹神経核 / アプリシア神経節
Research Abstract

This project is aimed at revealing the basic mechanisms of the "distributive processing" in the nervous system, and is organized as the international collaboration of three research groups which have a common technique for optical recording of neuronal activities using voltage-sensitive dyes. From 1995 to 1997, following studies have been carried out.
1. K.Kamino's group :
(1) The ontogenic organization of spatiotemporal patterns of neuronal activities in the nuclei of the brainstem (nucleus tractus soritarii, dorsal motor nerve of the vagus nerve, and nucleus ambiguus) of the embryonic chick and rat were analyzed from the view point of "distributive processing".
(2) The functional organization of the spinal cord of the chick embryo was also studied. (This study was related that of L.B.Cohen's group.)
2. L.B.Cohen's group :
(1) The distributive processing mechanism in the abdominal ganglion of Aplysia was studied.
(2) The fining pattern of the motor neurons of the embryonic chick spinal cord was analyzed. (This study was related to that of K.Kamino's group as started above.)
(3) The spreading pattern and distributive processing of the neural information in the turtle visual cortex were studied.
3. B.M.Salzberg's group :
(1) Neuronal activities of the submucous plexus of guinea pig small intestine were recorded optically from several ganglia, and the inter-neuronal and inter-ganglionic distributive processing of neuronal information was analyzed.
(2) The distributive processing of excitation-secretion coupling of mouse hypothalamo-pituitary system was studied.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Sato, K.: "Responses to glossopharyngeal stimulus in the early enbryonic chick brainstem:spatiotemporal patterns in three dimensions from repeated multiple site optical recording of electrical activity." Journal of Neuroscience.15. 2123-2140 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato, Y.: "Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity." Journal of Membrane Biology. 144. 167-176 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, K: "Optical studies of the biphasic modulatory effects of glycine on EPSPs in the chick brainstem and their embryogenesis." Neuroscience. 72. 833-846 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, K.: "Optical illustration of glutamate-induced cell swelling coupled with membrane depolarization in embryonic brain stem slices." NeuroReport. 8. 3559-3563 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato, Y.: "Optical characterization of a novel GABA response in early embryonic chick brainstem." Neuroscience. 80. 203-219 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, K.: "Optical mapping of neural responses in the embryonic rat brainstem with reference to the early functional organization of vagal nuclei." Journal of Neuroscience. 18. 1345-1362 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato, Y.: "GABA:Receptors,Transporters and Metabolism:Advances in Pharmacological Sciences." Birkhauser,Basel,Switzerland, 328 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, K: "Optical mapping of neural responses in the embryonic rat brainstem:early functional organization of vagal nuclei: In"Frontiers of Neural Development"" Springer-Verlag,Tokyo(in press), (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato K,Momose-Sato Y,Sakai T,Hirota A and Kamino K: "Responses to glossopharyngeal stimulus in the early embryonic chick brainstem : spatiotemporal patterns in three dimensions from repeated multiple-site optical recording of electrical activity." J.Neurosci.15. 2123-2140 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirota A,Sato K,Momose-Sato Y,Sakai T and Kamino K: "A new simultaneous 1020-site optical recording system for monitoring neural activity using voltage-sensitive dyes." J.Neurosci.Methods. 56. 187-194 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato Y,Sato K,Sakai T,Hirota A and Kamino K: "A novel gamma-aminobutyric acid response in the embryonic brainstem as revealed by voltage-sensitive dye recording." Neuroscie.Lett.191. 193-196 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato Y,Sato K,Sakai T,Hirota A,Matsutani K and Kamino K: "Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity." J.Membrane Biol.144. 167-176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato K,Momose-Sato Y,Hirota A,Sakai T and Kamino K: "Optical studies of the biphasic modulatory effects of glycine on excitatory postsynaptic potentials in the chick brainstem and their embryogenesis." Neuroscience. 72. 833-846 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato Y,Sato K,Hirota A,Sakai T,Yang X-S and Kamino K: "Optical characterization of a novel GABA response in early embryonic chick brainstem." Neuroscience. 80. 203-219 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato K,Momose-Sato Y,Arai Y,Hirota A and Kamino K: "Optical illustration of glutamate-induced cell swelling coupled with membrane depolarization in embryonic brain stem slices." NeuroReport. 8. 3559-3563 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yang X-S and Kamino K: "Photometric assessment of volume changes coupled with membrane potential in valinomycin-incorporated red blood cells." Jpn.J.Physiol.47. 217-230 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakai T,Hirota A,Momose-Sato Y,Sato K and Kamino K: "Optical mapping of conduction patterns of normal and tachucardia-like excitations in the rat atrium." Jpn.J.Physiol.47. 179-188 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato K,Momose-Sato Y,Hirota A,Sakai T and Kamino K: "Optical mapping of neural responses in the embryonic rat brainstem with reference to the early functional organization of vagal nuclei." J.Neurosci.18. 1345-1362 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato Y,Sato K,Hirota A and Kamino K: "GABA-induced intrinsic light scattering changes associated with voltage-sensitive dye signals in embryonic brainstem slices : coupling of depolarization and cell shrinkage." J.Nerophysiol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakai T,Momose-Sato Y,Sato K,Hirota A and Kamino K: "Optical monitoring of synaptic transmission in bullfrog sympathetic ganglia using a voltage-sensitive dye." Neurosci.Lett.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Momose-Sato Y,Sato K,sakai T,Hirota A and Kamino K: A novel GABA response identified optically in the nucleus of the tractus solitarius of the chick embryo.In "GABA : Receptots, Transporters and Metabolism". (ed.) Tanaka C and Bowery N G,Birkaeuser Verlag, Basel Switzerland, 255-258 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato K,Momose-Sato Y,Arai Y and Kamino K: Optical mapping of neural responses in the embryonic rat brainstem : early functional organization of vagal nuclei.In "Frontiers of Neural Development" Springer Verlag, Tokyo, in press,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sato, K.: "Optical illustration of glutamate indued cell swelling coupled with membrane depolarization in embryonic brain stem slices." NeuroReport. 8. 3559-3563 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Momose-Sato, Y.: "Optical characterization of a novel GABA response in early embryonic chick brainstem." Neuroscience. 80. 203-219 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakai, T.: "Optical mapping of conduction patters of normal and tachycardia-like excitations in the rat atrium." Japanese Journal of Physiology. 47. 179-188 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato, K.: "Optical mapping of neural responses in the embryonic rat brainstem with reference to the early functional organization of vagal nuclei." Journal of Neuroscience. 18. 1345-1362 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Momose. Sato, Y.: "GABA induced intrinsic light-scattering changes associated with voltage-sensitive by signals in embryonic brainstem slices coupling of depolarization and cell shrinkage." Journal of Neurophysiology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakai, T.: "Optical monitoring of synaptic transmission in bullfrog symathetic ganglia using a voltage sensitive dye." Neuroscience Letters. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato, K.: "Optical mapping of neural responses in the embryonic rat brainstem : early functional orgnization of vagal nucle : In “Frontiers of Neural development"" Springer-Verlag, Tokyo (in press), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 神野 耕太郎: "「脳の科学」創刊号.脳の機能発生1形成を光学的イメージングでとらえる." 星和書店(in press), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Momose-Sato,Y.: "Optical mapping of early embryonic expressions of Mg^<2+_>/APV-sensitivecomponents of vagal glutaminergic EPSPs in the chick brainstem." The Journal of Nruroscience. 14. 7572-7584 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato.K.: "Responses to glossopharyngeal stimulus in the early enbryonic chick brainstem : spatiotemporal patterns in three dimensions from repeated multiple site optical recording of electrical activity." The Journal of Neuroscience. 15. 2123-2140 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Momose-Sato,Y.: "A novel γ aminobutyric acid response in the embryonic brainstem as revealed by voltage-sensitive dye recording." Neuroscience Letters. 191. 193-196 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Momose-Sato,Y.: "Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity." The Journal of Membrane Biology. 144. 167-176 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hirota,A.: "A new simultaneous 1020-site optical recording system for monitoring neural activity using voltage-sensitive dyes," Journal of Neuroscience Methods. 56. 187-194 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato,K.: "Optical studies of the biphasic modulatory effects of glycine on EPSPs in the chickbrainstem and their embryogenesis." Neuroscience. 72. 833-846 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 共立出版、東京: "1993" 膜学実験シリーズ第1巻 生体膜編, (424)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kamino,K.: "Progress in Biomedical Optics : Proceedings of Clinical Applications of Modern Imaging Technology II." SPIE,Bellingham W.A.,USA, 494 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 佐藤容子: "膜学実験シリーズ第1巻 生体膜編" 共立出版、東京, 424 (1993)

    • Related Report
      1996 Annual Research Report
  • [Publications] Momose-Sato,Y.: "GABA : Receptors,Transporters and Metabolism : Advances in Pharmacological Sciences." Birkhauser,Basel,Switzerland, 328 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Momse‐Sato,Y.: "Optcal mappuing of early embryonic expressions ofMg^<2+>/APV sensitivecomponents of vagal glutaminergic EPSPs in the chick brainstem." The Journal of Neuroscience. 14. 7572-7584 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sato,K.: "Responses to glossopharyngeal stimulus in the early enbryonic chick brainstem:spatiotemporal patterns in three dimensions from repeated multiple-site optical recording of electrical activity." The Journal of Neuroscience. 15. 2123-2140 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Momse‐Sato,Y.: "A novel γ‐aminobutyric acid response in the embryonic brainstem as revealed by voltage-sensitive dye recording." Neuroscience Letters. 191. 193-196 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Momose‐Sato,Y.: "Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity." The Journal of Membrane Biology. 144. 167-176 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirota,A.: "A new simultaneous 1020-site optical recording system for monitoring neural activity using voltage-sensitive dyes." Journal of Neuroscience Methods. 56. 187-194 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sato,K.: "Optical studies of the biphasic modulatory effects of glycine on EPSPs in the chick brainstem and their embryogenesis." Neuroscience. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 酒井哲郎: "膜学実験シリーズ第1巻 生体膜編" 共立出版、東京, 424 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kamino,K.: "Progress in Biomedical Optics:Proceedings of Clinical Applications of Modern Imaging Technology II." SPIE,Bellingham W.A.,USA, 494 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 佐藤容子: "膜学実験シリーズ第1巻 生体膜編" 共立出版、東京, 424 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Momose-Sato,Y.: "GABA:Receptors,Transporters andMetabolism:Advances in Pharmacological Sciences." Birkhauser,Basel,Switzerland(in press), (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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