• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Japan-French Joint Research on Genome

Research Project

Project/Area Number 07044266
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Molecular biology
Research InstitutionInternational Institute for Advanced Studies (1997)
Osaka University (1995-1996)

Principal Investigator

MATSUBARA Kenichi  International Institute for Advanced Studies, Vice Director, 副所長 (20037394)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroshi  Nara Institute of Science and Technology, Graduate School of Biological Sciences, バイオサイエンス研究科, 教授 (70019876)
FUJIYAMA Asao  National Institute of Genetics, Division of Human Genetics, Associate Professor, 総合遺伝研究系, 助教授 (60142311)
SAKAKI Yoshiyuki  The University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (10112327)
OGASAWARA Naotake  Nara Institute of Science and Technology, Graduate School of Biological Science,, バイオサイエンス研究科, 教授 (10110553)
ITOH Takashi  The University of Tokyo, Institute of Medical Science, Assistant Professor, 医科学研究所, 助手 (90201326)
GUELLAEN GEO  国立衛生医学研究所(INSERM), 部長
JORDAN BERTR  フランス科学研究庁, 生命科学部, 部長
DUJON BERNAR  フランス科学研究庁, 生命科学部, 部長
ROIZES GERAR  フランス科学研究庁, 生命科学部, 部長
DANCHIN ANTO  フランス科学研究庁, 生命科学部, 部長
DELABAR JEAN  フランス科学研究庁, 生命科学部, 部長
GALIBERT FRA  フランス科学研究庁, 生命科学部, 部長
SLONIMSKI PI  フランス科学研究庁(CNRS), 名誉所長
村上 康文  理化学研究所ライフサイエンス筑波研究センター, 先任研究員 (90200279)
高木 利久  東京大学, 医科学研究所, 教授 (30110836)
大木 操  国立がんセンター研究所, 放射線研究部, 部長 (00158792)
吉田 光昭  東京大学, 医科学研究所, 教授 (80012607)
松田 文彦  京都大学, 遺伝子実験施設, 助手 (50212220)
宮野 悟  九州大学, 理学部, 教授 (50128104)
林崎 良英  理化学研究所, ライフサイエンス筑波研究センター, 主任研究員 (70192705)
中村 祐輔  東京大学, 医科学研究所, 教授 (70217909)
辻 省次  新潟大学, 脳研究所, 教授 (70150612)
小原 雄治  国立遺伝学研究所, 遺伝情報研究センター, 助教授 (70135292)
金久 實  京都大学, 化学研究所, 教授 (70183275)
大久保 公策  大阪大学, 細胞生体工学センター, 助教授 (40233069)
阿部 達生  京都府立医科大学, 医学部, 教授 (60079746)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 1997: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 1996: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1995: ¥12,000,000 (Direct Cost: ¥12,000,000)
KeywordsGenome research / Structural analyzes / Functional analysis / Genome informatics / Human genome / Analysis of B.subtilis / Yeast genome / Database
Research Abstract

To meet the need for deeper collaborative efforts on human disease genes, genome structure of model organisms, genome informatics, two French scientists, Drs.P.Bouvagnet and J.Thierry-Mieg were added to the member's list. Both of them came to Japan for collaborative researches.
Based upon agreement between Matsubara and Dr.F.Galibert at CNRS,special efforts have been made to promote collaborative activities that include such researchers as Sakaki, Ohki, Fujiyama (human genome structure), Yoshikawa, Ogasawara, Murakami, Ito (microbial genome structure), Takagi (genome informatics), Matsubara (cDNA). Matsuda (Research collaborator) visited Pasteur Institute and CNRS Montpellier to carry out collaboration on human immunoglobulin gene. Exchanges of young researchers were also actively promoted. French scientists who came to Japan for collaboration included P.Bouvagnet, P.Slonimski, A.Danchin, J.Thierry-Mieg.
On December 1997, Matsubara, Fujiyama, along with Wakasugi (Research collaborator) visited Paris and dislcussed with Drs.Samarut (CNRS Life Science Director) and Galibert (do., Vice director), summarizing achievements in these three years and exchanged ideas on future perpectives. As a result, the following consensus was obtrained. (1) This collaboration program has greatly helped mutual understanding, generating reliable and deep interactions among the participants, and as a result several new collaborative efforts have been initiated. (2) Ongoing collaborative researchers should be enforced. (3) Supports for exchanges should be sought for futhersing mutual understanding and stimulations ; especially encouraging exchange of young researchers for better interactions for the future.
The resume of the three years' activities will be published in an well-circulated international journal.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (241 results)

All Other

All Publications (241 results)

  • [Publications] Sumimoto, H.(Itoh, T): "Membrane translocation of cytosolic factors in activation of the phagocyte NADPH oxidase : role of protein-protein interactions" Membrance proteins:Structure,Function and Expression Control(eds.Mihara,K.& Hamasaki,N.)S.Karger AG,Switzerland. 235-245 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kito, K.(Ito, T.Sakaki, Y.): "Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells" Gene. 184. 73-81 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, T. and Sasaki, Y.: "Fluorescent differential display : a fast and safe way for reliable differential display analysis" Fingerprinting Methods Based on Arbitrarily Primed PCR(eds.Micheli,M.R. & Bova,R.)Springer-Verlag,Heidelberg. 305-313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furihata, C.(Itoh, T.): "Differentially expressed MHC class II-associated invariant chain in rat stomach pyloric mucosa with N-methyl-N^1nitro-N-nitrosoguanidine exposure" Cancer Res.57. 1416-1418 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Furihata, C.(Itoh, T.): "Rare occurrence of ras and p53 gene mutation in mouse stomach tumors induced N-methyl-N-nitrosourea" Jpn.J.Cancer Res.88. 363-368 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, T.and Sakaki, Y.: "Fluorescent differential display" Methods Mol.Biol.,Differential Display Methods and Protocoles(eds.Liang,P.& Pardee,A.B.)Humana Press Inc.,Totowa,NJ. 85. 37-44 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Adaci, N.(Itoh, T.): "Isolation and expression study of a maternally expressed novel Xenopus gene Xeml encoding a putative evolutionarily conserved membrane protein" Biochem.Biophys.Res.Commun.238. 899-904 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hagiwara, Y.(Itoh, T.): "Screening for imprinted genes by allelic messege display:Identification of a paternally expressed gene Impact on mouse chromosome 18" Proc.Natl.Acad.Sci.USA. 94. 9249-9254 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mizuki, K.(Itoh, T.): "Functional modules and expression of mouse p40^<phox> and 67^<phox>,Src homology 3(SH3)domain-containing proteins involved in the phagocyte NADPH oxidase complex" Eur.J.Biochem.251. 573-582 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura, R.(Itoh, T.): "The PC motif: A novel and evolutionarily conserved sequence involved in interaction between p40^<phox> and 67^<phox>,SH3 domain-containing cytolsolic factors of the phagocyte NADPH oxidase" Eur.J.Biochem.251. 583-589 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hata, K.(Itoh, T.): "Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47^<phox> and 67^<phox>,both in C terminally truncated forms:Implication for regulatory SH3 domain-mediated interactions" J.Biol.Chem.273. 4232-4236 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ito, T.and Sakaki, Y.: "Fluorescent differential display(FDD):A fast and reliable method for messege display PCR" Methods Enzymol,inpress.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Arai, Y.(Ohki, M.): "The inv(11)(p15q22)chromosome translocation of de nove and therapy-related myeloid malignancies results in fusion of the nucleoporin gene,NUP98,with the putative RNA helicase gene,DDX10" Blood. 89. 3936-3944 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hosoda, F.(Ohki, M.): "A complete Not1 restiction map covering the entire long arm of human chromosome 11" Genes to Cells. 2. 345-347 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kitamura, E.(Ohki, M.): "A3-Mb sequence-ready contig map encompassing the multiple disease gene cluster on chromosome 11q13.1-q13.3" DNA Res.4. 281-289 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kunst, F.(Ogasawara, N.): "The complete genome sequence of the gram-positive bacterium Bacillus subtilis" Nature. 390. 249-256 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kasahara, Y.(Ogasawara, N.): "Sequence analysis of the groESL-cotA region of the Bacillus subtilis genome,containing the restriction/modification system gene" DNA Res.4. 335-339 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Liu, H.(Ogasawara, N., Yoshikawa, H.): "Sequence analysis of a 25-kb segment in the 17-19 degree region of the Bacillus subtilis chromosome containing ada locus" DNA Res.4. 325-328 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Beloin, C.(Ogasawara, N.): "Characterization of a lrp-like gene Bacillus subtilis" Mol.Gen.Genet. 256. 63-71 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sadaie, Y.(Ogasawara, N.): "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome" Microbiology. 143. 1861-1866 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kasahara, Y.(Ogasawara, N.): "Sequence analysis of the 36kb region between gnte and trny genes of Bacillus subtilis genome" DNA Res.4. 155-159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Coillie, E.V.(Sakaki, Y.): "The human MCP-2 gene(SCYA8):cloning,sequence analysis,tissue expression,and assignment to the CC chemokine gene contig on chromsome 17q11.2" Genomics. 40. 323-331 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kamino, K.(Sakaki, Y.): "A variety of presenilin 1 mutations in Japanese familial early-onset Alzheimer's disease" Alzheimer's Disease : Biology,Diagnosis and Terapeutics. 79-84 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori, M.(Sakaki, Y.): " A novel method for making nested deletions and its application for sequencing of a 300kb region of human APP locus" Nucleic Acids Research. 25. 1802-1808 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hata, K.(Sakaki, Y.): "Identification of critical CpG sites for repression of L1 transcription by DNA methylation" Gene. 189. 227-234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohira, M.(Sakaki, Y.): "Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21" Genome Res.47. 47-58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura, A.(Sakaki, Y.): "Isolation of a novel human gene from the down syndrome critical region on chromosome 22q22.2" J.Biochem.122. 872-877 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakamura, A.(Sakaki, Y.): "A novel gene isolation from human placenta located in Down syndrome critical region on chromosome 21" DNA Res.4. 321-324 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tei, H.(Sakaki, Y.): "Circadian oscillation of a mammalian homologue of the Drosophila period gene" Nature. 389. 512-516 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsukahara, F.(Sakaki, Y.): "Molecular characterization of mouse mtprd gene,the homologue oh human TPRD:the unique gene expression suggesting its critical role in pathophysiology of Down syndrome" J.Biochem.,in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsukamoto, Y.(Takagi, T.): "Application of a deductive database system to search to search for topological and similar three-demensional structures in protein" Computer Applications in the Biosciences. 13. 183-190 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohta, Y.(Takagi, T.): "Automatic construction of knowledge base from biological papers" Proc.of the Fifth International Conference on Intelligent Systems for Molecular Biology. 218-225 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Satou, K.(Takagi, T.): "Extraction of substructures of proteins essential to their biological functions by a data mining technique" Proc.of the Fifth International Conference on Intelligent Systems for Molecular Biology. 254-257 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsunoda, T.(Takagi, T.): "Automatic extraction of position specific cooccurence of transcription factor bindings on promoters" Proc.of the Pacific Symposium on Biocomputing '98. 252-263 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fukuda, K.(Takagi, T.): "Toward information extraction: Identifying protein names from biological papers" Proc.of the Pacific Symposium on Biocomputing '98. 707-718 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tenzen, T.(Fujiyama, A.): "Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex" Mol.Cell.Biol.17. 4043-4050 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤山 秋佐夫: "二次元電気泳動によるゲノムスキャンニング法" シリーズ・ニューバイオフィジックス「ヒューマンゲノム計画」(金久 實編). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 藤山 秋佐夫: "ゲノムリソースの作成とゲノム生物学への適用" 蛋白質核酸酵素. 42. 2472-2747 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Okubo, K.and Matsubara, K.: "Complementary DNA sequence(EST)collections and the expression information of the human genome" FEBS Letters. 403. 225-229 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda, K.(Matsubara, K.): "Analysis of an expression profile of genes in the human adipose tissue" Gene. 190. 227-235 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshikawa, H.(Fujiyama, A., Matsubara, K.): "Chromosome assignment of aberrant NotI restriction DNA fragments in primary hepatocellular carcinoma" Gene. 197. 129-135 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumoto, A.(Matsubara, K.): "An expression profile of genes in human retina and isolation of a cDNA for a novel rod photoreceptor protein" IOVS. 38. 2576-2585 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsuo, N.(Matsubara, K.): "Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus" Biochem.Biophys.Res.Commun.238. 126-129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuriyama, H.(Matsubara, K.): "Molecular cloning and expression of a novel aquaporin from adipose tissue with glycerol permeability" Biochem.Biophys.Res.Commun.241. 53-58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsumoto, A.(Matsubara, K.): "An expression profile of genes in human retina and isolation of a cDNA for a novel rod photoreceptor protein" IOVS. 38. 2576-2585 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsuo, N.(Matsubara, K.): "Cloning of a cDNA encoding a novel sugar trensporter expressed in the neonatal mouse hippocampus" Biochem.Biophys.Res.Commun.238. 126-129 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kuriyama, H.(Matsubara, K.): "Molecular cloning and expression of a novel aquaporin from adipose tissue with glycerol permeability" Biochem.Biophys.Res.Commun.241. 53-58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Eki, T.(Murakami, Y.): "Cloning and characterization of novel gene DCRR1,expressed from Down's syndrome critical region of human chromosome 21q22.2" DNA Sequence. 7. 153-164 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohiara, M.(Murakami, Y.): "Gene idendification in 1.6-Mb region of the Down syndrome region on chromosome 21" Genome Res.7. 47-58 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Naitou, M.(Murakami, Y.): "Expression profiles of transcripts from 126 ORFs in Saccharomyces cerevisiae chromosome VI by systematic Northern analyse" Yeast. 13. 1275-1290 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishiai, M.(Murakami, Y.): "Isolation of human and fission yeast gene homologues of the budding yeast origin recognition complex subunit Orc5:Human homologue(ORC5L)maps to chromosome band 7q22" Genomics. 46. 294-298 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sakamoto, A.(Murakami, Y.): "Both hypertronic and dilated cardiomyopatgies are caused by mutation of the same gene delta-sarcoglycan,in hamster:An animal model of disrupted dystrophin-associated glycoprotein complex" Proc.Natl.Acad.Sci.USA. 94. 13873-13878 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Eki, T.(Murakami, Y.): "Mapping of the human genes encoding cyclin H(CCHH)and the CDK-activating kinase(CAK)assembly factor MAT1(MNAT1)to chromosome bands 5q13.3-q14 and 14q23,respectively" Genomics. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sumimoto, H.(Itoh, T.): "Membrane translocation of cytosolic factors in activation of the phagocyte NADPH oxidase:role of protein-protcin interactions" Membrane Proteins:Structure,Function and Expression Control(eds.Mihara,K.& Hamasaki,N.)S.Karger AG,Switzerland. 235-245 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kito, K.(Ito, T., Sakaki, Y.): "Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells" Gene. 184. 73-81 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito.T.and Sakaki, Y.: "Fluorescent differential display: a fast and safe way for reliable differential display analysis" Fingerprinting Methoda Based on Arbitrarily Primed PCR(eds.Micheli,M.R. & Bova,R.)Springer-Verlag,Heidelberg. 305-313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Furihata, C.(Itoh, T.): "Differentially expressed MHC class II-associated invariant chain in rat stomach pyloric mucosa with N-methyl-N^1nitro-N-nitrosoguanidine exposure" Cancer Res.57. 1416-1418 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Furihata, C.(Itoh, T.): "Rare occurrence of ras and p53 gene mutation in mouse stomach tumors induced N-methyl-N-nitrosourea" Jpn.J.Cancer Res.88. 363-368 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito, T.and Sakaki, Y.: "Fluorescent differential display" Methods Mol.Biol.,Differential Display Methods and Protocoles (eds. Liang,P.& Pardee,A.B.)Humana Press Inc.,Totowa,NJ. 85. 37-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Adaci, N.(Itoh, T.): "Isolation and expression study of a maternally expressed novel Xenopus gene Xem1 encoding a putative evolutionarily conserved membrane protein" Biochem.Biophys.Res.Commun.238. 899-904 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hagiwara, Y.(Itoh, T.): "Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18" Proc.Natl.Acad.Sci.USA. 94. 9249-9254 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mizuki, K.(Itoh, T.): "Functional modules and expression of mouse p40^<ph ox>and67^<ph ox>,Src homology 3 (SH3) domain-containing proteins involved in the phagocyte NADPH oxidase complex" Eur.J.Biochem.251. 573-582 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura, R.(Itoh, T.): "The PC motif: A novel and evolutionarily conserved sequence involved in interaction between p40^<ph ox> and 67^<ph ox>,SH3 domain-containing cytolsolic factors of the phagocyte NADPH oxidase" Eur.J.Biochem.251. 583-589 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hata, K.(Itoh, T.): "Anionic amphiphile-independent activation of the phagocyle NADPFH oxidase in a cell-free system by p47^<ph ox> and 67^<ph ox>, both in C terminally truncated forms: Implication for regulatory SH3 domain-mediated interactions" J.Biol.Chem.273. 4232-4236 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito, T.and Sakaki, Y.: "Fluorescent differential display (FDD):A fast and reliable method for message display PCR" Methods Enzymol, inpress.

    • Related Report
      1997 Annual Research Report
  • [Publications] Arai, Y.(Ohki, K.): "The inv (11)(p15q22)chromosome translocation of de nove and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10" Blood. 89. 3936-3944 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hosoda, F.(Ohki, M.): "A complete Notl restriction map covering the entire long arm of human chromosome 11" Genes to Cells. 2. 345-347 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitamura, E.(Ohki, M.): "A3-Mb sequence-ready contig map encompassing the multiple disease gene cluster on chromosome 11q13.1-q13.3" DNA Res.4. 281-289 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kunst, F.(Ogasawara, N.): "The complete genome sequence of the gram-positive bacterium Bacillus subtilis" Nature. 390. 249-256 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kasahara, Y.(Ogasawara, N.): "Sequence analysis of the groESL-cotA region of the Bacillus subtilis genome, containing the restriction/modification system gene" DNA Res.4. 335-339 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Liu, H.(Ogasawara, N., Yosihkawa, H.): "Sequence analysis of a 25-kb segment in the 17-19 degree region of the Bacillus subtilis chromosome containing ada locus" DNA Res.4. 325-328 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Beloin, C.(Ogasawara, N.): "Characterization of a lrp-like gene Bacillus subtilis" Mol. Gen. Genet.256. 63-71 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sadaie, Y.(Ogasawara, N.): "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome" Microbiology. 143. 1861-1866 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kasahara, Y.(Ogasawara, N.): "Sequence analysis of the 36kb region between gntE and trnY genes of Bacillus subtilis genome" DNA Res.4. 155-159 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Coillie, E.V.(Sakaki, Y.): "The human MCP-2 gene(SCYA8):cloning, sequene analysis, tissue expression, and assignment to the CC chemokine gene contig on chromsome 17q11.2" Genomics. 40. 323-331 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamino, K.(Sakaki, Y.): "A variety of presenilin 1 mutations in Japanese familial early-onset Alzheimer′s disease" Alzheimer′s Disease:Biology, Diagnosis and Terapeutics. 79-84 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hattori, M.(Sakaki, Y.): "A novel method for making nested deletions and its application for sequencing of a 300kb region of human APP locus" Nucleic Acids Research. 25. 1802-1808 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hata, K.(Sakaki, Y.): "Identification of critical CpG sites for repression of L1 transcription by DNA methylation" Gene. 189. 227-234 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohira, M.(Sakaki, Y.): "Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21" Genome Res.47. 47-58 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura, A.(Sakaki, Y.): "Isolation of a novel human gene from the Down syndrome critical region on chromosome 22q22.2" J.Biochem.122. 872-877 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakamura, A.(Sakaki, Y.): "A novel gene isolation from human placenta located in Down syndrome critical region on chromosome 21" DNA Res.4. 321-324 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tei, H.(Sakaki, Y.): "Circadian oscillation of a mammalian homologue of the Drosophila period gene" Nature. 389. 512-516 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsukahara, F.(Sakaki, Y.): "Molecular characterization of mouse mtprd gene, the homologue oh human TPRD: the unique gene expression suggesting its critical role in pathophysiology of Down syndrome" J.Biochem., in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsukamoto, Y.(Takagi, T.): "Application ofa deductive database system to search to search for topological and similar three-demensional structures in protein" Computer Applications in the Biosciences. 13. 183-190 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohta, Y.(Takagi, T.): "Automatic construction of knowledge base from biological papers" Proc. of the Fifth International Conference on Intelligent Systems for Molecular Biology. 218-225 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Satou, K.(Takagi, T.): "Extraction of substructures of proteins essential to their biological functions by a data mining technique" Proc. of the Fifth International Conference on Intelligent Systems for Molecular Biology. 254-257 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tsunoda, T.(Takagi, T.): "Automatic extratic of position specific cooccurence of transcription factor bindings on promoters" Proc. of the Pacific Symposium on Biocomputing '98. 252-263 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukuda, K.(Takagi, T.): "Toward information extraction: Idenifying protein names from biological papers" Proc.of the Pacific Symposium on Biocomputing '98. 707-718 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tenzen, T.(Fujiyama, A.): "Precise switching of DNA replication timing in the GC content transition area in the human major histocompatibility complex" Mol.Cell.Biol.17. 4043-4050 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤山 秋佐夫: "二次元電気泳動によるゲノムスキャンニング法" シリーズ・ニューバイオフィジックス「ヒューマンゲノム計画」(金久 寛編). (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤山 秋佐夫: "ゲノムリソースの作成とゲノム生物学への適用" 蛋白質核酸酵素. 42. 2472-2747 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Okubo, K.and Matsubara, K.: "Complementary DNA sequence(EST) collections and the expression information of the human genome" FEBS Letters. 403. 225-229 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maeda, K.(Matsubara, K.): "Analysis of an expression profile of genes in the human adirose tissue" Gene. 190. 227-235 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yosikawa, H.(Fujiyama, A.Matsubara, K.): "Chromosome assignment of aberrant NotI restriction DNA fragments in primary hepatocellular carcinoma" Gene. 197. 129-135 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto, A.(Matsubara, K.): "An expression profile of genes in human retina and isolation of a cDNA for a novel rod photoreceptor protein" IOVS. 38. 2576-2585 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsuo, N.(Matsubara, K.): "Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus" Biochem. Biophys. Res. Commun.238. 126-129 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kuriyama, H.(Matsubara, K.): "Molecular cloning and expression of a novel aquaporin from adipose tissue with glycerol permeability" Biochem. Biophys. Res. Commun.241. 53-58 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto, A.(Matsubara, K.): "An expression profile of genes in human retina and isolation of a cDNA for a novel rod photoreceptor protein" IVOS. 38. 2576-2585 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsuo, N.(Matsubara, K.): "Cloning of a cDNA encoding a novel sugar trensporter expressed in the neonatal mouse hippocampus" Biochem.Biophys.Res.Commun.238. 126-129 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kuriyama, H.(Matsubara, K.): "Molecular clonig and expression of a novel aquaporin from adipose tissue with glycerol permeability" Biochem.Biophys.Res.Commun.241. 53-58 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Eki, T.(Murakami, Y.): "Cloning and characterization of novel gene DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2" DNA Sequence. 7. 153-164 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohiara, M.(Murakami, Y.): "Gene idendification in 1.6-Mb region of the Down syndrome region on chromosome 21" Genome Res.7. 47-58 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naitou, M.(Murakami, Y.): "Expression profiles of transcripts from 126 ORFs in Saccharomyces cerevisiae chromosome VI by systematic Northern analyse" Yeast. 13. 1275-1290 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishiai, M.(Murakami, Y.): "Isolation of human and fission yeast gene homologues of the budding yeast. origin recognition complex subunit Orc5: Human homologue(ORC5L)maps to chromosome band 7q22" Genomics. 46. 294-298 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakamoto, A.(Murakami, Y.): "Both hypertronic and dilated cardiomyopatgies are caused by mutation of the same gene delta-sarcoglycan, in hamster: An animal model of disrupted dystrophin-associated glycoprotein complex" Proc.Natl.Acad.Sci.USA. 94. 13873-13878 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Eki, Y.(Murakami, Y.): "Mapping of the human genes encoding cyclin H(CCNH)and the CDK-activating kinase(CAK)assembly factor MAT1(MNAT1)to chromosome bands 5q13.3-q14 and 14q23,respectively" Genomics,in press.

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito,T.and Sakaki,Y.: "Fluorescent differential display method for high-speed scanning of tissue-or cell-specific transcripts" Human Molecular Genetics:Methods Mol.Genet.(ed.Adolph,K.W.)Academic Press,San Diego. vol.8. 229-245 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,T.: "An SH3 domain-mediated interaction between the phagocyte NADPH oxidase factors p40^<phox> and p47^<phox>" FEBS Letter. 385. 229-232 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sumimoto,H.(Ito,T.): "Assembly and activation of the phagocyte NADPH oxidase:specific interaction of the N-terminal Src Homology 3(SH3)domain of p47^<phox> with p22^<phox> is required for activation of the NADPH oxidase" J.Biol.Chem.271. 22152-22158 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,T.and Sakaki,Y.: "Toward genome-wide scanning of gene expression:a functional aspect of the Genome Project" Essays in Biochemistry(ed.Apps,D.K.)Portland Press,London. vol.31. 11-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sumimoto,H.(Ito,T.): "Membrane translocation of cytosolic factors in activation of the phagocyte NADPH oxidase:role of protein-protein interactions" Membrane Proteins:Structure,Function and Expression Control(Eds.Mihara,K.and Hamasaki,N.)Kyusyu Univ.Press,Fukuoka. 227-237 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kito,K.(Ito,T.,Sakaki,Y.): "Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells" Gene. 184. 73-81 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,T.and Sakaki,Y.: "Fluorescent differential display:a fast and safe way for reliable analysis of differential display" Fingerprinting Methods Based on Arbitrarily Primed PCR Random Amplification Methods(Eds.Micheli,M.R.and Bova,R.)Springer-Verlag,Heidelberg. 305-313 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito,T.and Sakaki,Y.: "Fluorescent differential display" Differential Display:Methods and Applications;Methods Mol.Biol.(Eds.Pardee,A.B.and Liang,P.)Humana Press Inc.,Totowa. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Furihata,C.(Ito,T.): "Differentially expressed MHC class II-associated invariant chain in rat stomach pyloric mucosa with N-methy1-N^1-nitro-N-nitroguanidine exposure" Cancer Res.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Hattori,M.(Sakaki,Y.): "Novel method for making nested deletions and its application for sequencing of a 300kb APP gene locus" Nucleic Acids Res.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato,S.(Sakaki,Y.): "Splivcing mutation of Presenilin 1 gene for early-onset familial Alzheimer's disease" Human Mutation. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamamoto,Y.(Takagi,T.): "Constructing a dictionary of biological terms for information extraction" 7th Workshop on Genome Informatics. 260-261 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohta,Y.(Takagi,T.): "Information finding from biological papers" 7th Workshop on Genome Informatics. 258-259 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshikawa,H.(Matsubara,K,Fujiyama,A.): "Chromosome Assignment of Human Genomic NotI Restriction Fragments in a Two-Dimensional Electrophoresis Profile" Genomics. 31. 28-35 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawamoto,S.(Matsubara,K.): "Expression profiles of active genes in human and mouse livers" Gene. (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kita,H.(Matsubara,K.): "An expression profile of active genes in cultured human keratinocytes" DNA Res.3. 1-7 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Maeda,K.(Matsubara,K.): "cDNA cloning and expression of a novel adipose specific collagen-like factor,apM1(AdiPose most abundant gene transcript 1)" Biochem.Biophys.Res.Commun.221. 286-289 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohno,I.(Matsubara,K.): "A cDNA cloning of human AEBP1 from primary cultured osteoblast and it's expression in a differentiating osteoblastic cell line" B.B.R.C.228. 411-414 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nishida,K.(Matsubara,K.): "An expression profile of active genes in human corneal epithelium and the isolation of human keratin 12 cDNA" Invest.Ophthalmol.Vis.Sci.37. 1800-1809 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu-Matsumoto,A.(Matsubara,K.): "Isolation and chromosomal localization of human cone cGMP phosphodiesterase g cDNA" Genomics. 32. 121-124 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Okubo,K.and Matsubara,K.: "Complementary DNA sequence(EST)collections and the expression information of the human genome" FEBS Letters. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Goffeau(Murakami,Y.): "Life with 6000 genes" Science. 274. 546-567 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Eki,T.(Murakami,Y.): "Analysis of a 36.2-kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae" Yeast. 12. 149-167 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Eki,T.(Murakami,Y.): "Fifteen open reading frames in a 30.8-kb region of the right arm of chromosome VI from Saccharomyces cerevisiae" Yeast. 12. 177-190 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Naitou,M.(Murakami,Y.): "Sequencing of 23kb fragment,clone gapB and 4682 of Saccharomyces cerevisiae Chromosome VI" Yeast. 12. 77-84 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ariyama,T. (Abe,T.): "High-resolution cytogenetic map of the short arm of chromosome 1 with newly isolated 411 cosmid markers by flouresence in situ hybridization ; precise ordering 18 markers on 1p36.1 on prophase chromosomes and “stretched" DNAs" Genomics. 25. 114-123 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Morishima,Y. (Abe,T.): "Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization" Genomics. 28. 273-279 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ichikawa,D. (Abe,T.): "Multiple primary cancers with microsatellite instability : Report of a case" Jpn.J.Cancer Res.87. 105-108 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Harada,H. (Abe,T.): "Bipolar affective disorder associated with ア-Thalassemia minor" Biol.Psychiatry. 37. 477-480 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shiojima,I. (Abe,T.): "Assignment of Cardiac homeobox gene CSX to human chromosome 5q34" Genomics. 27. 204-206 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Taketani,S. (Abe,T.): "The human protoporphybinogen oxidase gene : Organization and location to chromosone 1" Genomics. 29. 698-703 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Marukawa,O. (Abe,T.): "Molecular cloning of the breakpoint of t (11;22) (q23;q11) chromosome translocation in an adult acute myelomonocytic leukemia" Brit.J.Haematol.,. (in press). (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inazawa,J. (Abe,T.): "PTPN13,a Fas-associated protein tyrosine phosphatase,located on the long arm of chromosome 4 at band q21.3" Genomics,. (in press). (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ichikawa,D. (Abe,T.): "Analysis of numerical aberrations of specific chromosomes by fluorescemce in situ hybridization (FISH) as a diagnostic tool in breast cancer" Cancer,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Gardiner,K. (Ohki,M.): "Localization of cDNAs to a region poorly represented in the CEPH chromosome 21 YAC contig : candidate genes for genetic diseases mapped to 21q22.3" Genomics. 30. 376-379 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Goto,M. (Ohki,M.): "Assignment of the E4TF1-60 gene to human chromosome 21q21.2-21.3" Gene. 166. 337-338 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohira,M. (Ohki,M.): "A 1.6 Mb P1-based physical map of the Down syndrome region on chromosome 21" Genomics,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohira,M. (Ohki,M.): "Identification of a novel gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21" DNA Res.,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okubo,K.Matsubara,K.: "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles" Genomics. 30. 178-186 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakamoto,Y. (Ogasawara,N.,Yoshikawa,H): "The Bacillus subtilis dnaC gene encodes a protein homologous to the DnaB helicase of Escherichia coli" Microbiol.141. 641-644 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akagawa,E. (Ogasawara,N.): "Determination of 17,484 bp nucleotide sequence around 39o region of the Bacillus subtilis chromosome andsimilarity analysis of the products of putative ORFs" Microbiol.141. 3241-3245 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Aroya,S. (Ogasawara,N.): "The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination" J.Mol.Biol.,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida,K. (Ogasawara,N.): "Cloning and sequencing of a 40.5 kb region of the Bacillus subtilis genome containing the bglS and cel loci ; creation of a 177 kb contig covering from the gnt to sacXY loci" DNA Res.,. (in preparation).

    • Related Report
      1995 Annual Research Report
  • [Publications] Barnes,T. (Kohara,Y.): "Meiotic recombination,non-coding DNA and genomic organization in Caenorhabditis elegans" Genetics. 141. 159-179 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tabara,H. (Kohara,Y.): "A multi-well version of in situ hybridization on whole mount embryos of C.elegans" Nucl.Acids Res.,. (submitted).

    • Related Report
      1995 Annual Research Report
  • [Publications] Zhao,N. (Sakaki,Y.): "High-destiny cDNA filter analysis : a novel approach for large-scale,quantitative analysis of gene expression" Gene. 156. 207-213 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Adachi,N. (Sakaki,Y.): "Differential display analysis of gene expression in developing embryos of Xenopus laevis" Biochimica et Biophysica Acta. 1262. 43-51 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Araki,E (Sakaki,Y.): "Transgenic mice expressing the amyloid protein-contaning carboxyl-terminal fragment of the Alzheimer amyloid precursor protein" Amyloid. 2. 100-106 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Alemeida,M.R. (Sakaki,Y.): "Haplotype analysis of common transthyretin mutations" Hum.Genet.96. 350-354 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kurose,K. (Sakaki,Y.): "RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system" Nucleic Acids Res.23. 3704-3709 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kato,M. (Sakaki,Y.): "Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death" Lancet. 345(8959). 1247 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takahashi,N. (Sakaki,Y.): "High-density cDNA filter analysis of the expresion profiles of the genes preferentially expressed in human brain" Gene. 164. 219-227 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toyoda,A. (Sakaki,Y.): "Mode of activation of the GC box/Spl-dependent promoter of the human NADH-cytochrome b5 reductase-encoding gene" Gene. 164. 351-355 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Cher,M.L. (Sakaki,Y.): "Mapping of Regions of Physical Deletion on Chromosome 16q in Prostate Cancer Cells by Fluorescence in situ Hybridization (FISH)" J.Urol. 153. 249-254 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ito,T. (Sakaki,Y.): "Fluorescent differential display method for high-speed scanning of cell-specific transcripts methods" Mol.Genet.8. 229-245 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ito.T. (Sakaki,Y.): "Fluorescent Differential Display (FDD) : A Fast and Safe Way for Reliable DD Analysis in Springer Lab Manual : Fingerprinting Methods Using PCR" Springer-Verlag, (Eds.Micheli,M.R.and Bova,R.). (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shibata,A. (Sakaki,Y.): "Identification of cis-acting elements involved in an alternative splicing of the amylod precursor protein (APP) gene" Gene,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hattori,M. (Sakaki,Y.): "Mutation detection by orphan peak analysis in CRC Press book : The Detection of DNA sequence polymorphisms and mutations" Methods and Applications,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suzuki,T. (Sakaki,Y.): "Regional and cellular presenilin 1 gene expression in human and rat tissues" Biochem.Biophys.Res.Commun.,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Naruse,K. (Sakaki,Y.): "A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2" Genomics,. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hattori,M. (Sakaki,Y.): "Novel method for making nested deletions and its application for sequencing of a 300 kb APP gene locus" (submitted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tsukahara,F. (Sakaki,Y.): "Cloning of a novel cDNA encoding tetratricopeptide repeat (TPR) motif from Down syndrome critical region 21q22.2" (submitted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ito,T. (Sakaki,Y.): "Fluorescent Differential Display Reveals a Male-Specific Band in Mouse Liver That Encodes a Member of Cytochrome P450 4A Family" (submitted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kito,K. (Sakaki,Y.): "Fluorescent Differential Display Analysis of Gene Expression of Differentiating Neuroblastoma" (submitted). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Satou,K. (Takagi,T.): "Development of a deductive database system for computing closures of similarity relationships among protein structures" Journal of Japanese Society for Artificial Intelligence. 11(3). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shibayama,G. (Takagi,T.): "Mining association rules from signals found in mammalian promoter sequence" Genome Informatics Workshop 1995. 108-109 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Uchiyama,I. (Takagi,T.): "Protein sequence grouping by peptide word motifs" Genome Informatics Workshop 1995. 116-117 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Murakami,K. (Takagi,T.): "Evaluation of exon prediction tools using a long DNA sequence data" Genome Informatics Workshop 1995. 98-99 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogiwara,A. (Takagi,T.): "A WWW Database of Bacillus Subtilis ORFs determined by the International Project of Sequencing B.Subtilis Genome" Genome Informatics Workshop 1995. 162-163 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogiwara,A. (Takagi,T.): "Sequence Analysis using Databases and Networks (Part 1),in Japanese" Cell Technology. 14(5). 577-588 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogiwara,A. (Takagi,T.): "Sequence Analysis using Databases and Networks (Part 2),in Japanese" Cell Technology. 14(6). 709-721 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高木 利久: "ゲノム情報" ゲノム情報,情報処理学会編 新版 情報処理ハンドブック. 862-867 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorubral-Pallidoluysian Atrophy (DRPLA) : Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat" Ann.Neurol.37. 769-775 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Onodera,O. (Tsuji,S.): "Molecular cloning of cDNA for dentatorubral-pallidoluysian atrophy (DRPLA) and regional expressions of the expanded alleles in the central nervous system" Am.J.Hum.Genet.57. 1050-1060 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ichinose,H. (Tsuji,S.): "Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene" Nature Genet.8. 236-242 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Burke,J.R. (Tsuji,S.): "Dentatorubral-pallidoluysian atrophy and Haw River syndrome" Lancet. 344. 1711-1712 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka,H. (Tsuji,S.): "The gene for hereditary progressive dystonia with marked diurnal fluctuation maps to chromosome 14q" Ann.Neurol.37(3). 769-775 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorubral-pallidoluysian atrophy (DRPLA) : close correlationof CAG repeat expansions with the wide spectrum of clinical presentations and prominent anticipaiton" Seminars in Cell Biology. 6(1). 37-44 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeuchi,T. (Tsuji,S.): "Dentatorbral-pallidoluysian atrophy (DRPLA). Molecular basis for wide clinical features of DRPLA" Clin.Neurosci.3(1). 23-27 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sanpei,K. (Tsuji,S.): "Direct detection of expanded (CAG/CTG) repeats in the myotonin-protein kinase genes of myotonic dystrophy patients using a high-stringency hybridization method" Biochem.Biophys.Res.Commun.212(2). 341-346 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okuizumi,K. (Tsuji,S.): "Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease" Nature Genet.11. 207-209 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Onodera,O. (Tsuji,S.): "Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expression of the expanded alleles in the CNS" Am.J.Hum.Genet.57(5). 1050-1060 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takiyama,Y. (Tsuji,S.): "Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease" Hum.Mol.Genet.4(7). 1137-1146 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koike,R. (Tsuji,S.): "Partial deletions of putative adrenoleukodystrophy (ALD) gene in Japanese ALD patietns" Hum.Mutation. 6. 263-267 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoneda,M. (Tsuji,S.): "Detection and quantification of point mutations in mtDNA by PCR" Methods in Enzymology,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakatsuru,S. (Nakamura,Y.): "Isolation and mapping of a novel human gene encoding a product homologous to yeast proteins involving in DNA replication" Cytogenet.Cell Genet.68. 226-230 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Fujiwara,Y. (Nakamura,Y.): "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor deta gene" Oncogene. 10. 891-895 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katagiri,T. (Nakamura,Y.): "Human metalloprotease/disintegrin-like (MDC) Gene : Exon-intron organization and alternative splicing" Cytogenet.Cell Genet.68. 39-44 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Arakawa,H. (Nakamura,Y.): "Molecular cloning,characterization,and chromosomal mapping of a novel human gene that is highly homologous to Xenopus transcription factor III" Cytogenet.Cell Genet.70. 235-238 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Chinen,K. (Nakamura,Y.): "Isolation and mapping of human beta-signal sequence receptor gene" Cytogenet.Cell Genet.70. 215-217 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kawakami,T. (Nakamura,Y.): "Isolation and mapping of a human gene that is highly homologous to PR-8,a rat gene associated with programmed cell death" Cytogenet.Cell Genet.71. 41-43 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ariyama,T. (Nakamura,Y.,Abe,T.): "Precise ordering of 26 cosmid markers on chromosome region 3p23-p21.3 by two-color FISH on human prophase chromosomes and stretched DNAs" Cytogenet.Cell Genet.70. 129-133 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ariyama,T. (Nakamura,Y.,Abe,T.): "High-resolution cytogenetic mapping of the short arm of chromosome 1 with newly isolated 411 cosmid markers by fluorescence in situ hybridization : The precise order of 18 markers on 1p36.1 on prophase chromosomes and “stretched" DNAs" Genomics. 25. 114-123 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Koyama,K. (Nakamura,Y.): "Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification" Genomics. 26. 245-253 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikegawa,S. (Nakamura,Y.): "Isolation,characterization and chromosomal assignment of human colligin2" Cytogenet.Cell Genet.71. 182-186 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikegawa,S. (Nakamura,Y.): "Mutations of the fibroblast growth factor-3 gene in one familial and six sporadic cases of Japanese patients with achondroplasia" Human Genet.96. 309-311 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Spurr,N.K. (Nakamura,Y.): "Report of the second international workshop on human chromosome 8 mapping 1994" Cytogenet.Cell Genet.68. 147-164 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Miura,K. (Nakamura,Y.): "Deletion mapping in squamous cell carcinomas of the esophagus defines a region containing a Tumor Suppressor Gene Within a 4-cM Interval of the distal long arm of chromosome 9" Cancer Res.55. 1828-1830 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inoue,S. (Nakamura,Y.): "Chromosomal mapping of human (ZNF147) and mouse gene for estrogen-responsive finger protein (efp),a member of the RING finger family" Genomics. 25. 581-583 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sudo,K. (Nakamura,Y.): "Isolation,and mapping of human cDNA homologous to murine protein synthesis initiation factor 4A-II (eIF4A-II)" Cytogenet.Cell Genet.71. 385-388 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Saito,H. (Nakamura,Y.): "Isolation,and mapping of a novel human gene encoding a protein contaiing Zinc-finger structures" Genomics,in press.

    • Related Report
      1995 Annual Research Report
  • [Publications] Koyama,K. (Nakamura,Y.): "The human homologue of the murine mgl-I gene maps within the Smith-Magenis-Syndrome region in 17p11.2" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Saito,H. (Nakamura,Y.): "Cloning and mapping of a human novel cDNA that encodes a protein highly homologous to yeast nuclear protein NHP2" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Fujiwara,T. (Nakamura,Y.): "Cloning,sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit)" DNA Research. 2. 107-111 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toda,T. (Nakamura,Y.): "Genetic identity of Fukuyama-type congenital muscular dystrophy and Walker-Warburg syndrome" Ann.Neurol.37. 99-101 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Soejima,H. (Nakamura,Y.): "Fifty novel sequences-tagged sites (STSs) on human chromosome 11q13.4-q25 identified from microclones generated by microdissection" Cytogenet.Cell Genet.70. 108-111 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takiguchi-Shirahama,S. (Nakamura,Y.): "Germline mutations of the RET proto oncogene in eight Japanese patients with multiple endocrine neoplasia (MEN2A)" Hum.Genet.95. 187-190 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hofstra,R.M.W. (Nakamura,Y.): "Ordering of markers in the pericentromeric region of chromosome 10" Hum.Genet.96. 116-118 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nahmias,J. (Nakamura,Y.): "Cosmid contigs spanning 9q34 including the candidate region for TSC1" Eur.J.Hum.Genet.3. 65-77 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inoue,M. (Nakamura,Y.): "Isotation and characterization of a novel human cDNA clone homologous to a yeast transcription activator,GCN5" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Furukawa,Y. (Nakamura,Y.): "Isolation and mapping of a novel human gene that is homologous to RPD3,a transcription factor in Saccharomyces cerevisiae" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,T. (Nakamura,Y.): "Molecular cloning of a novel human cDNA,RT14,containing a putative ORF highly conserved between human,fruit fly,and nematode" DNA Research. 2. 235-237 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Toda,T. (Nakamura,Y.): "Dinucleotide repeat polymorphism on chromosome 9q32" Jpn.J.Hum.Genet.40. 333-334 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Isomura,M. (Nakamura,Y.): "Cloning and mapping of a novel human cDNA homologous to DR OER,the enhancer of the Drosophila melanogaster rudimentary gene" Genomics,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka,T. (Nakamura,Y.): "Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ninomiya,S. (Nakamura,Y.): "Isolation of a testis-specific cDNA on chromosome 17q from a region adjacent to the breakpoint of t (12;17) observed in a patient with acampomelic campomelic dysplasia and sex reversal" Hum.Mol.Genet.5. 69-72 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Watanabe,T. (Nakamura,Y.): "Cloning,expression,and mapping of h-UBC9,a gene encoding a human homologue of ubiquitin-conjugating enzymes that are critical for regulating the cell cycle in teas" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikegawa,S. (Nakamura,Y.): "Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) In patients with Schmid metaphyseal chondrodysplasia" Human Mutation,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Tokino,T. (Nakamura,Y.): "Characterization of the human p57 KIP2 gene ; Alternative splicing,Insertion/deletion polymorphisms in VNTR sequences in the coding region,and mutational analysis" Hum.Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka,T. (Nakamura,Y.): "Molecular cloning of a novel human cDNA encoding putative cysteine protease and its chromosomal assignment to 14q32.1" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Mori,T. (Nakamura,Y.): "Isolation and mapping of a novel human gene homologous to yeast CDCs 3,10,11,and 12,and mouse DIFF" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Okita,K. (Nakamura,Y.): "Definition of the locus responsible for systemic carnitine deficiency within a 1.6-cM region of mouse chromosome 11 by detailed linkage analysis" Genomics,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Chinen,K. (Nakamura,Y.): "Isolation and mapping of a novel gene,partially homologous to yeast SEC14,that contains variable number of tandem repeat (VNTR) in the 3′ untranslated region" Cytogenet.Cell Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohta,T. (Nakamura,Y.): "Isolation of a cosmid clone corresponding to an inv (21) breakpoint of a patient with transient abnormal myelopoiesis" Am.J.Hum.Genet.,. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] 高木 利久: "ゲノムネットのデータベース利用法" 共立出版, (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤山 秋佐夫: "染色体操作技術、組織培養" 5-6 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤山 秋佐夫: "ヒト染色体のソーティング、組織培養" 47-51 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Honjo,T.and Matsuda,F.: "Immunoglobulin heavy chain loci of mouse and man Immunoglobulin Genes (T.Honjo and FW.Alt,eds.)" Academic Press,London,U.K., 145-171 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsuda,F.and Honjo,T.: "Organization of the human immunoglobulin heavy-chain locus Advances in Immunology (F.Dixon,ed.)" Academic Press,San Diego,in press,

    • Related Report
      1995 Annual Research Report
  • [Publications] 小原 雄治: "線虫C.エレガンスの細胞死の遺伝子カスケード 「アポトーシスの分子医学」(橋本嘉幸、山田武 編)" 羊土社, 26-36 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小原 雄治: "線虫C.elegansゲノムの発現マップ、細胞工学 14" 秀潤社, 661-666 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小原 雄治: "座談会、情報生物学の現状と将来、蛋白質核酸酵素 40" 羊土社, 1784-1802 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 林崎 良英: "ゲノム解析研究と医学分野における将来への展望" Pharma Medica, 51-56 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 林崎 良英: "DNA多型検出の戦略 DNA多型 3" 東洋書店, 10-15 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hayashizaki,Y.: "Restriction landmark genomic scanning (RLGS), Molecular Biology and Biotechnology" VCH publishers, 813-817 (1995)

    • Related Report
      1995 Annual Research Report

URL: 

Published: 1995-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi