| Project/Area Number |
07044287
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Nagoya City University |
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Principal Investigator |
OHTA Nobuo Nagoya City University, Medical School, Professor, 医学部, 教授 (10143611)
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| Co-Investigator(Kenkyū-buntansha) |
何 永康 湖南省寄生虫病防治研究所, 主任
賀 宏武 湖南省寄生虫病防治研究所, 助研究員
張 仁利 湖南省寄生虫病防治研究所, 助研究員
黄 令霞 湖南省寄生虫病防治研究所, 主任
陳 炎 湖南省寄生虫病防治研究所, 副所長
鐘 志南 湖南省寄生虫病防治研究所, 副研究員
羅 仕栄 湖南省衛生庁血吸虫病防治弁公室, 主任
MARUYAMA Haruhiko Nagoya City University, Medical School, Research Associate, 医学部, 助手 (90229625)
ITOH Makoto Aichi Medical University, Associate Professor, 助教授 (90137117)
KANAZAWA Tamotsu National Institute of Health, Chief, 室長 (10194888)
HIRAYAMA Kenji Saitama Medical School, Professor, 教授 (60189868)
KAJIHARA Noriaki Yamanashi Institute for Public Health, Chief, 主任研究員
SHO Masanori Yamanashi Medical University, Research Associate, 助手 (90154682)
MINAI Masaru Yamanashi Institute for Public Health, Director, 部長
NAKAJIMA Yasuo Yamanashi Medical University, Professor, 教授 (20039845)
HOSAKA Yukio Tokyo Medical College, Professor, 教授 (60072873)
LUO Shiyong Hunan Institute of Parasitic Diseases, Chief
HE Hongbin Hunan Institute of Parasitic Diseases, Lecuturer
ZHONG Zhinian Hunan Institute of Parasitic Diseases, Research Associate
ZHANG Renli Hunan Institute of Parasitic Diseases, Lecuturer
HUANG Linxia Hunan Institute of Parasitic Diseases, Research Associate
HE Yongkang Hunan Institute of Parasitic Diseases, Research Associate
CHEN Yan Hunan Institute of Parasitic Diseases, Director
錘 志南 湖南省寄生虫病防治研究所, 副研究員
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 1996: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1995: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | Schistosoma japonicum / Antibody / hepatic fribrosis / HLA / TNF-alpha / ELISA / Ultrasonography / type IV collagen / 血清診断 / B型肝炎 / 肝脾住血吸虫病 / 循環抗原 / 遺伝疫学 |
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| Research Abstract |
Epidemiological analysis was done in an endemic area of marshland-type achistosomiasis japonica in China. The aim of this cooperative research project was to characterize endemic patterns of schistosomiasis in the studied area, to identify risk factors for the infection, and to develop effective countermeasure for this disease. We did survey in Rinjiang village, Hunan Province, of which population size was 1,144, and the village is located a long with the Yangzhi river. We collected blood and urine samples from residents, and tested for antibody titers, HLA and TNF-alpha as genetic markers, and serum level of type IV collagen and mesenchimal metaroproteinase-2 (MMP-2). Hepatic fibrosis induced by Schistosoma japonicum infection was diagnosed ultrasonographically based on the criteria of WHO.We tested 500 residents randomly, and 180 were tested consecutively in the two years.
Of the tested subjects, 26.8% were seropositive for S.japonicum, indicating past infection of the parasite. Serop
… More
ositive rate was significantly elevated in (a) males, (b) adults and (c) farmers. Individuals belong to this group showed significantly high water-contact, and at the same time reinfection rate in these 18 months was significantly high in this group. Although we studied habitant areas of the intermediate snail hosts in this village, we did not observed significant association between seropositive rate and intensity of snail distribution possible because the village was too small (1.48km^2).
We tried to develop new method for evaluating epiodemiological parameters ; detection of schistosome antigens and anti-schistosome antibodies in urine and detecting serum parameters correlated with degree of hepatic fibrosis. We observed that antibody level in urine showed significant association with that of serum antibody. Serum levels of type IV collagen and MMP-2 were also correlated with degree of hepatic fibrosis. Those results suggests their probable usefulness in epidemiological study because of the easy handling and cost-effectiveness. Less
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