| Project/Area Number |
07044303
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MATSUDA Takehisa National Cardiovascular Center Research Institute, Director, 生体工学部, 部長 (60142189)
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| Co-Investigator(Kenkyū-buntansha) |
SATOU Siniti National Cardiovascular Center Research Institute, Staff, 医学部, 講師 (30178735)
NAKAYAMA Yasuhide National Cardiovascular Center Research Institute, Staff, 生体工学部, 室員 (50250262)
MASUDA Mititaka National Cardiovascular Center Research Institute, Senior Staff, 循環器形態部, 室長 (00190364)
FUJIWARA Keigi National Cardiovascular Center Research Institute, Director, 循環器形態部, 部長 (10190092)
SAMET Mark M Univ.of Wisconsin, Adjunct Professor
NIKOLAYCHIK Victor Univ.of Wisconsin, Adjunct Professor
LELKES Peter I Univ.of Wisconsin, Director
棚橋 雅美 国立循環器病センター研究所, 生体工学部, 室員
MARK M.Samet ウィスコンシン大学, 細胞生物学研究所, 助教授
VICTOR Nikol ウィスコンシン大学, 細胞生物学研究所, 助教授
PETER I Lelk ウィスコンシン大学, 細胞生物学研究所, 部長
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1996: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Mechanical stress / Hybrid Tissue / Tissue Engineering / Cells / 細胞 / 内皮細胞 / 機械刺激 / 血管壁 |
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| Research Abstract |
The international collaborative study between National Cardiovascular Center and University of Wisconsin have launched to deepen understanding of vascular cell types under mechanical stress field and its potential applications to tissue-engineered and artificial organs such as vascular vessels and hearts. At the National Cardiovascular Center, vascular cell types include endothelial cells and smooth muscle cells have been exposed to hydrodynamic sheer stress and mechanical distension, which have studied focusing cytoskeletal arrangement and phenotype alteration. Hierarchical structured hybrid tissues were constructed and impianted into canine arteries. On the other hand, endothelialization on Milwaukee Heart was achieved.
Exchange of information, techniques and methodologies upon mutual visits to respective institutes were very useful fon conducting ongoing projects at both sides.
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