• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of nociceptive system in pathologic conditions

Research Project

Project/Area Number 07044318
Research Category

Grant-in-Aid for International Scientific Research.

Allocation TypeSingle-year Grants
Research InstitutionNagoya University

Principal Investigator

KUMAZAWA Takao  Research Institute of Environmental Medicine, Nagoya University.professor, 環境医学研究所, 教授 (20022775)

Co-Investigator(Kenkyū-buntansha) REEH P.w.  University of Erlangen/Nurnberg professor, 生理学部, 教授
HANDWERKER H.o.  University of Erlangen/Nurnberg professor, 生理学部, 教授
MESSLINGER K.  University of Wurzburg Lecturer, 生理学部, 講師
SCHMIDT R.f.  University of Wurzburg professor, 生理学部, 教授
KASAI Masanori  Research Institute of Environmental Medicine, Nagoya University.Assistant, 環境医学研究所, 助手 (30202005)
SATO Jyun  Research Institute of Environmental Medicine, Nagoya University.Assistant, 環境医学研究所, 助手 (00235350)
MIZUMURA Kazue  Research Institute of Environmental Medicine, Nagoya University.Associate Profes, 環境医学研究所, 助教授 (00109349)
Project Period (FY) 1995
Project Status Completed (Fiscal Year 1995)
KeywordsNociceptor / Inflammation / Hyperalgesia / Chronic pain / Neurophysiology / Sympathetic excitation / Bradykinin / Prostagrandin E_2 / Dorsal root ganglion neurone
Research Abstract

(1) We studied effects of protein kinase-C activation by a phorbol ester, phorbol 12,13 dibutyrate (PDBu), on the polymodal receptor activities using canine testis-spermatic nerve preparations. PDBu (>=10^<-7>M) induced a weak but long-lasting excitation after long latency (longer than 5 min). The heat response was facilitated by PDBu (>=10^<-8>M). The similar effect was observed in knee joint afferents but at 10-6M.The bradykinin response was either suppressed or facilitated depending of application method of PDBu. To compare difference in sensitivities to chemical substances, we also tried to develop a new in vitro visceral preparation using dura, pleura, and mesentery. In cooperation with Susanne Brehm, whom we additionally invited to our lab because of her experience in pleura and skin preparations, we succeeded to record from mesentery preparations.
(2) In adjuvant-inflamed rats, polymodal receptors were excited by sympathetic activation or epinephrine injection. It was also demonstrated that this excitation is mediated through alpha_2 receptor, and it depends neither on the alpha_2 receptor on the sympathetic nerve nor on prostaglandin synthesis.
(3) In cultured cell within 24 hr.with and without nerve growth factor (NGF), the bradykinin (BK) and prostagrandin E_2 (PGE_2) did not affect membrane potential, membrane input resistance of capsaicin (CAP)-sensitive dorsal root ganglion (DRG) Cells. BK and/or PGE_2 depolarized CAP-sensitive cells cultured for 48 hrs with NGF but not without NGF.The BK-induced depolarization might be through B2-receptors, since the B1-receptor agonist did not affect the cells. A low concentration of PGE_2, which did not afffect the cells, enhanced the BK-induced depolarization in cultured cells with NGF.At present we have a good possibility to clarify the mechanisms of action of mediators on nociceptor membrane or intracellular dynamics using intracellular recording from DRG cells cultured with NGF.

Report

(1 results)
  • 1995 Final Research Report Summary
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] SUZUKI Shigeyuki,SATO Jun,MIZUMURA Kazue,KUMAZAW Takao: "Hyperalgesia and sensitization ofcutaneous polymodal receptors induced byclioquinol in rats." Pain Research. 10. 89-91 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] MIZUMURA Kazue,MINAGAWA Munenori,KODA Hisashi,KUMAZAWA Takao: "Influence of histamine on the bradykinin response of canine testicular poloymodal receptors in vitro." Inflammation Reseach. 44. 376-378 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KASAI Masanori,MIZUMURA Kazue,KUMAZAWA Takao: "Characteristics of capsaicin-sensitive neurones freshly dissociated from rat dorsal root ganglion" Environmental Medicine. 39. 45-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TAMURA Ryoko,MIZUMURA Kazue,SATO Jun,KITOH Junzo,KUMAZAWA Takao: "Segmental distribution of afferent neurons innervating the canine testis.21GC04:Journal of the Autonomic Nervous System" (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KUMAZAWA Takao,MIZUMURA Kazue,KODA Hisashi,FUKUSAKO Hiroe: "EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in responses to bradykinin and heat." Journal of Neurophysiology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TSUJI Yoichiro,KOEDA Tomoko,SATO Jun,SUZUKI Shigeyuki,KUMAZAWA Takao: "Sympathetically induced paradoxical increases of the cutaneous blood flowin chronically inflamed rats." Jounal of the Autonmic Nervous System. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 熊澤孝朗: "“痛みのメカニズム.「刺激の受容と生体運動」"新医科学体系第7巻" 中山書店, 15 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KUMAZAWA Takao: "“Sensitization of polymodal receptors."In:Neurobiology of Nociceptors." Oxford Univ.Press:Oxford, ((in press))

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 水村和枝: "“変化する環境と痛み-雨降りの日に関節が痛むのはなぜか-"21世紀の環境を考える,地球・太陽・宇宙" 日刊工業新聞社, 11 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] SUZUKI Shigeyuki, SATO Jun, MIZUMURA Kazue, KUMAZAWA Takao: "Hyperalgesia and sensitization of cutaneous polymodal receptors induced by clioquinol in rats." Pain Research. 10. 89-91 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] MIZUMURA Kazue, MINAGAWA Munenori, KODA Hisashi, KUMAZAWA Takao: "Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro." Inflammation Research. 44. 376-378 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KASAI Masanori, MIZUMURA Kazue, KUMAZAWA Takao: "Characteristics of capsaicin-sensitive neurones freshly dissociated from rat dorsal root ganglion." Environmental Medicine, Nagoya University. 39. 45-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TAMURA Ryoko, MIZUMURA Kazue, SATO Jun, KITOH Junzo, KUMAZAWA Takao: "Segmental distribution of afferent neurons innervating the canine testis." Journal of the Autonomic Nervous System. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KUMAZAWA Takao, MIZUMURA Kazue, KODA Hisashi, FUKUSAKO Hiroe: "EP receptor subtypes implicated in the PGE_2-induced sensitization of polymodal receptors in responses to bradykinin and heat." Journal of Neurophysiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] TSUJII Yoichiro, KOEDA Tomoko, SATO Jun, SUZUKI Shigeyuki, KUMAZAWA Takao: "Sympathetically induced paradoxical increases of the cutaneous blood flow in chronically inflamed rats." Jounal of the Autonmic Nervous System. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] KUMAZAWA Takao: Oxford Univ.Press : Oxford (in press). "Sensitization of polymodal receptors." In : Neurobiology of Nociceptors.,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

URL: 

Published: 1997-03-04   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi