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Interpretation of the mechanism of cardiovascular deconditioning induced by the long-term exposure to microgravity.

Research Project

Project/Area Number 07045048
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNagoya University

Principal Investigator

MANO Tadaaki  Nagoya University, Research Institute of Environmental Medicine, Professor, 環境医学研究所, 教授 (30023659)

Co-Investigator(Kenkyū-buntansha) EGOROV Anato  ロシア厚生省医学生物学研究所, 教授
KOZLOVSKAYA イネッサ  ロシア厚生省医学生物学研究所, 教授
GRIGOIEVV An  ロシア厚生省医学生物学研究所, 所長
SUGIYAMA Yoshiki  Nagoya University, Research Institute of Environmental Medicine, Assistant Profe, 環境医学研究所, 助手 (50240809)
IWASE Satoshi  Nagoya University, Research Institute of Environmental Medicine, Associate Profe, 環境医学研究所, 助教授 (90184879)
GRIGORIEV Anatoly  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
KOZLOVSKAYA Inessa B.  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
EVOROV Anatolya D.  Institute of Biomedical Problems, Ministry of Health of Russia, Professor
KOZLOVSKAYA イネッサ ビー  ロシア厚生省医学生物学研究所, 教授
GRIGORIEV An  ロシア厚生省医学生物学研究所, 所長
EVOROV Anato  ロシア厚生省, 医学・生物学研究所, 教授
KOZLOVSKAYA イネッサ・ビー・  ロシア厚生省, 医学・生物学研究所, 教授
GRIGRIEV Ana  ロシア厚生省, 医学・生物学研究所, 所長
EVOROV Anat  ロシア厚生省医学, 生物学研究所, 教授
KOZLOVSKAYA ビー コズロフスカヤ  ロシア厚生省医学, 生物学研究所, 教授
GRIGREIV An  ロシア厚生省医学, 生物学研究所, 所長
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsmuscle sympathetic nerve activity / cardiovascular deconditioning / microgravity / bed rest / dry immersion / static exerc / orthostatic stress / 微小神経電図法 / ヘッドアップティルト / 心拍変動 / 血圧変動 / -6゚ヘッドダウンティルト / dry immersion / 血管迷走神経性失神
Research Abstract

On return to the earth sfter spaceflight, cardiovascular deconditioning, including fall in blood pressure and sometimes syncope, is known to occur. Variable autonomic symptons were reported during spaceflight. However, the effect of microgravity on autonomic function is almostly unclear. We performed 3 days of dry immersion (DI) as the stimulation of short duration microgravity and 120 days of 6-degree head-down bed rest (BR) as that of long duration weightlessness.After 3 days of DI,resting muscle sympathetic nerve activity (MSNA) recorded with use of microneurography, and resting cardiac sympathetic nerve activity indicated by heart rate variability were higher than those before DI,and resting cardiac vagal activity was lower than that before DI.Systolic and diastolic blood pressure werre similar to that before DI.Increasing response of MSNA,cardiac sympathetic nerve activity and heart rate to orthostatic stress, and decreasing response of cardiac vagal activity to it were maintained. After 12 _o days of BR,resting MSNA and heart rate were higher than those before BR.Systolic and diastolic blood pressure werre similar to that before BR.Rises in MSNA and heart rate in response to orthostatic stress were maintained. Systolic and diastolic blood pressure resposes to it did not change. However, increasing response in MSNA to static leg exercise (30% maximal voluntary contraction) was declined and rise in mean blood pressure to it disappeared. 3 days of the exposure to microgravity and 120 days of it increased MSNA to almost same degree. From the assessment of changes in MSNA,heart rate (variability) and blood pressure, both of them did not effect autonomic responses to orthostatic stress, but the latter declined the MSNA response.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Iwase S, Sugiyama Y, Miwa T, Kouno M, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(1)" 環境医学研究所年報. 47. 38-42 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miwa T, Sugiyama Y, Iwase S, Kouno M, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(2)" 環境医学研究所年報. 47. 43-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sugiyama Y, Miwa T, Kouno M, Iwase S, Mano T: "3日間のdry immersionがヒトの心循環機能に及ぼす影響(3)" 環境医学研究所年報. 47. 47-50 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwase S,Mano T,Sugenoya J,Sugiyama Y,Matsukawa T: "Microneurographic study on sympathetic control of sweating and skin blood flow" Biomedical Thermology. 13. 460-464 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 1wase S,Mano T: "Skin sympathetic nerve activity and sweating" Neurological Medicine. 44. 121-130 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwase S,Ikeda T,Kitazawa H,Hakusui S,Sugenoya J,Mano T: "Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis" Journal of the Autonomic Nervous System. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwase S,Kitazawa H,Cuj J,Sawasaki N,Mano T: "Differentiation of skin sympathetic nerve activity to sudomotor and vasoconstrictor nerve components" EIectroencephalography and clinical Neurophysiology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwase S,Mano T,Sugenoya J,Sugiyama Y,Matsukawa T,Okamoto T,Yamamoto K: Microneurographic study on sympathetic control of sweating and skin blood flow, In : Mabuchi K,Mizushina S,Harrison B eds, Advanced Techniques and Clinical Applications in Biomedical Thermology. Harwood Academic Publishers, Chur, Switzerlnd, 147-162 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwase S,Okamoto T,Mano T,sugenoya J,sugiyama Y: Thermal dependency of sympathetic outflow to the skin. In : Nagasaka T,Milton AS,eds, Body Temperature and Metabolism. International Press Editing Center lncorporation, Tokyo, 137-140 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miwa C., Sugiyama Y., Iwase S., Mano T., Ohira Y., Grigoriev A., Kozlovskaya I., Egorov A., Shenkman B.: "Effects of three days of dry immersion on heart rate and blood pressure variabilities during head-up tilting in humans" Environmental Medicine. 41. 135-137 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mano T.: "Resarch activities on aerospace medicine in japan-Past,present,and future-" Korean Journal of Aerospace and Environmental Medicine. 7. 31-35 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mano T.: "Current research on hemodynamic control in human upright posture" springer Science. 13. 6-9 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 野間 忠明: "宇宙飛行と生体反応" 交通医学. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 間野 忠明: "ゆらぎの科学9" 宇宙飛行と自律神経系のゆらぎ(印刷中), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岩瀬 敏,間野忠明: "宇宙における神経電位の測定" BME. 10. 51-62 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩瀬 敏,杉山由樹,美和千尋,河野通之,間野忠明: "3日間のdry immersionがヒトの心循環器のうに及ぼす影響(1)-3日間のdry immersion前後における筋交感神経活動の変化" 名古屋大学環境医学研究所年報. 47(印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 美和千尋,杉山由樹,岩瀬 敏,河野通之,間野忠明: "3日間のdry immersionがヒトの心循環器のうに及ぼす影響(2)-3日間水新語の起立負荷に対する血圧および心拍変動" 名古屋大学環境医学研究所年報. 47(印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 杉山由樹,美和千尋,河野通之,岩瀬 敏,間野忠明: "3日間のdry immersionがヒトの心循環器のうに及ぼす影響(3)-3日間のdry immersion中の心拍及び血圧変動の変化" 名古屋大学環境医学研究所年報. 47(印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩瀬敏,野間忠明: "BME" 10. 宇宙における神経電位の測定. 51-62 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩瀬敏,杉山由樹,美和千尋,河野通之,野間忠明: "3日間のdry immersionがヒトの心循環器のうに及ぼす影響(1)-3日間のdry immersion前後における筋交感神経活動の変化" 名古屋大学環境医学研究所年報. 47(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 美和千尋,杉山由樹,岩瀬敏,河野通之,野間忠明: "3日間のdry immersionがヒトの心循環器のうに及ぼす影響(2)-3日間水新語の起立負荷に対する血圧および心拍変動" 名古屋大学環境医学研究所年報. 47(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉山由樹,美和千尋,河野通之,岩瀬敏,野間忠明: "名古屋大学環境医学研究所年報" 3日間のdry immersionがヒトの心循環器のうに及ぼす影響(3)-3日間のdry immersion中の心拍及び血圧変動の変化. 47. (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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