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イオン駆動型トランスポーターとチャネルの構造・機能協関

Research Project

Project/Area Number 07276102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionOkayama University

Principal Investigator

土屋 友房  岡山大学, 薬学部, 教授 (80012673)

Co-Investigator(Kenkyū-buntansha) 山口 明人  大阪大学, 産業科学研究所, 教授 (60114336)
野間 昭典  京都大学, 大学院・医学研究科, 教授 (00132738)
清野 進  千葉大学, 医学部, 教授 (80236067)
笠原 道弘  帝京大学, 医学部, 教授 (40010102)
乾 賢一  京都大学, 大学院・医学研究科, 教授 (70034030)
北里 宏  滋賀医科大学, 医学部, 教授 (20079700)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥108,100,000 (Direct Cost: ¥108,100,000)
Fiscal Year 1997: ¥29,600,000 (Direct Cost: ¥29,600,000)
Fiscal Year 1996: ¥32,000,000 (Direct Cost: ¥32,000,000)
Fiscal Year 1995: ¥46,500,000 (Direct Cost: ¥46,500,000)
Keywordsイオン / トランスポータ / チャネル / 構造と機能 / シンポータ / アンチポ-タ / クローニング
Research Abstract

ヒト先天性グルコース・ガラクトース吸収不全症の症例について、Na^+/グルコースシンポータのArg135がTrpに変換していることを明らかにした。Na^+/メリビオースシンポータについては、多数のキメラ体の作製と解析、部位特的変異導入による解析などから、大腸菌のメリビオース輸送タンパク質のIle304とVal312がH^+共役に関与していること、Asn58がNa^+認識に関与していることを明らかにした。また、ヒトH^+/オリゴペプチドシンポータの活性調節に関わるpH感受性制御因子をクローン化し、構造・輸送制御特性を明らかにした。
H^+/テトラサイクリンアンチポ-タについて、部位特異的Cys変異体を用いて膜貫通領域を正確に決定する方法を確立した。また、基質入口のゲート部位にあるGly64の解析から、膜を隔てた遠隔コンフォーメーション効果の存在を明らかにした。大腸菌と腸炎ビブリオのNa^+/H^+アンチポ-タNhaA系について膜内配向性が明らかになり、また機能に重要なアミノ酸残基が多数同定された。H^+/ノルフロキサシンアンチポ-タ遺伝子がクローニングされ一次構造が明らかになった。H^+/クロラムフェニコールアンチポ-タとともに構造と機能の関係が明らかになりつつある。一方、心筋のNa^+/Ca^<2+>アンチポ-タとNa^+,K^+ポンプがNa^+を介して密接に相互作用することが明らかになった。
膵β細胞のATP感受性K^+チャネルは、4分子のSURIと4分子のKir6.2から構成されている可能性が示された。また、SURIとKir6.2の遺伝子異常が家族制低血糖症の原因になりうることが示された。ATPはSURIのNBF-1と高親和性で結合し、この結合はMgADPがNBF-2と結合することにより拮抗されることが示された。

Report

(3 results)
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (93 results)

All Other

All Publications (93 results)

  • [Publications] Rafiquel I.Sarker: "Primary structure and properties of the Na+/glucose symporter (SglS) of Vibrio parahaemolyticus." Journal of Bacteriology. 179. 1805-1808 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noriko Okazaki: "Characteristics of the melibiose transporter and its primary structure in Enterobacter aerogenes." Biochim.Biophys.Acta. 1326. 83-91 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takato Noumi: "Identification and characterization of functional residuces in a Na+/H+ antiporter (NhaA) from Escherichia coli by random mutagenesis." Journal of Biochemistry. 121. 661-670 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kei Inaba: "Na+ (Li+) /H+ antiporter in Pseudomonas aeruginosa and effect of Li+ on cell growth." Biol.Pharm.Bull.20. 621-624 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kim Young-Mog: "Inhibition of melibiose transporter by amiloride in Escherichia coli." Biochem.Biophys.Res.Commun.233. 147-149 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noriko Okazaki: "A melibiose transporter and an operon containing its gene in Enterobacter cloacae." Journal of Bacteriology. 179. 4443-4445 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Eiji Tamai: "Purification of UhpT,the sugar phosphate transporter of Escherichia" Protein Exper.Purification. 10. 275-282 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tohru Mizushima: "Inhibition of thymine transport in dnaA mutants of Escherichia coli" J.Biol.Chem.272. 21195-21200 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Audrey C.Weissborn: "The construction of a cysteine-less melibiose carrier from Escherichia" Biochim.Biophys.Acta. 1329. 237-244 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noriko Okazaki: "Sequence of a melibiose transporter gene of Enterobacter cloacae" Biochim.Biopys.Acta. 1354. 7-12 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wakano Ogawa: "Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter,and cloning of a serine transporter gene." J.Biochem.122. 1241-1245 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Teruo Kuroda: "Mutational analysis og amiloride sensitivity in NhaA Na+/H+ antiporter from Vibrio parahaemolyticus." Journal of Bacteriology. 179. 7600-7602 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takata,K: "Transport of glucose across the blood-tissue barriers." Int.Rev.Cytol. 172. 1-53 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kasahara,M: "Amino acid residues responsible for galactose recognition in yeast Gal2 transporter." J.Biol.Chem.272. 16721-16724 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kasahara,T.: "Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae : comparison" Biochim.Biophys.Acta. 1324. 111-119 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kazuyo Kodama: "Preparation and characterization of everted membrane vesicles from cells of Staphylococcus aureus." Biol.Pharm.Bull.21. 5-9 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kaori Nozaki: "A new Na+/H+ antiporter,NhaD,of Vibrio parahaemolyticus." Biochim.Biophys.Acta. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shin,Y.: "Reconstituon of the F1-ATPase activity from purifiedα,β,randδ or ε subunits with glutathione S-transferase fused at their amino termini." Biochim.Biophys.Acta. 1273. 62-70 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sarker,R.I.: "Properties of a Na^+ / galactose (glucose) symport system in Vibrio Parahaemolyticus." Biochim.Biophys.Acta. 1279. 149-156 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sarker,R.I.: "Sequence of a Na^+ / glucose symporter gene and its flanking regions of Vibrio parahaemolyticus." Biochim.Biophys.Acta. 1281. 1-4 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nozaki,K.: "Cloning and sequencing of the gene for Na^+ / H^+ antiporter of Vibrio parahaemolyticus." Biochem.Biophys.Res.Commun.222. 774-779 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimamoto,T.: "Mutational analysis of the CitA citrate transporter from Salmonella typhimurium altered substrate specificity." Biohem.Biophys.Res.Commun.226. 481-487 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ohtomo,T.: "Transport of levofloxacin in a kidney epithelial cell line,LLC-PK1 Interaction with orqanic cation transporters in apical and basolatera" J.Pharmacol.Exp.Ther.276(3). 1143-1148 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ogihara,H.: "Immuno-Iocalization of H^+ / peptide cotransporter in rat digestive tract." Biochem.Biophys.Res.Commun.220(3). 848-852 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito,H.: "Molecular cloning and tissue distribution of rat peptide transporter PEPT2." Biochim.Biophys,Acta. 1280(2). 173-177 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,K.: "Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-qlycoprotein." Pharm.Res.13(7). 1073-1077 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nabekura,T.: "Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat brush-border membrane." Pharm.Res.13(7). 1069-1072 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Okuda,M.: "cDNA cloning and functional expression of a novel rat kidney organic cation transporter,OCT2." Biochem.Biophys.Res.Commum.224(2). 500-507 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito,H.: "Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney." J.Biol.Chem.271(34). 20719-20725 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takano,M.: "Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells." Am.J.Physiol.271. F469-F475 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nabekura,T.: "Cholesterol modulates organic cation transport activity and lipid fludity in rat renal brush-border membranes." Biochim.Biophys.Acta. 1283(2). 232-236 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Terada,T.: "Identification of the histidine residues invioved in substrate recogition by a rat H^+ / peptide cotransporter,PEPT1." FEBS Lett.394(2). 196-200 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Saito,H.: "Na^+-dependent uptake of 1,5-anhydro-D-glucitol via the transport systems for D-glucose and D-mannose in kidney epithelial cell line." Jpn.J.Nephrology. 38(10). 435-440 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kasahara,T.: "Expression of the rat GLUT1 transporter in the yeast Saccharomyces cerevisiae." Biochemical J.315. 177-182 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kasahara,M.: "Transmembrane segment 10 is important for substrate recognition in Gal2 and Hxt2 sugar transporters in the veast Saccharomyces cerevisiae" FEBS Lett.389. 174-178 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwasaki,N.: "Identification of microsatellite markers near human genes encoding the b-cell ATP-sensitive K^+ channel and linkage studies" Diabetes. 45. 267-269 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Wang,C-Z.: "Cloning and pharmacological characterization of a fourn P2X receptor subtype widely expressed in brain and peripheral tissues including" Biochem.Biophys.Res.Commun.220. 196-202 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Inagaki,N.: "A family of sulfonylurea feceptors determines the pharmacological properties of ATP-sensitive K^+ channels." Neuron. 16. 1011-1017 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Namba,N.: "Kir2.2v : a possible negative regulator of the inwardly recifying K^+ channel Kir2.2." FEBS Lett.386. 211-214 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Watabe,Y.: "Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cell." J.Biol.Chem.271. 25126-25130 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kubota,A.: "Effector coupling of somatostatin receptor subtypes on human endocrine tumors." Metabolism. 42-45 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Seino,S.: "Recent progress in molecular genetic aspects of non-insulin-dependent diabetes mellitus." Internal Medicine. 35. 347-355 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Seino,S.: "Molecular biology of the b-cell ATPsensitive K^+ channel." Diabetes Rev.4. 177-190 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Wang,Z.: "Cell distension-induced increase of the delayed rectifier K^+ current in guinea pig ventricular myocytes." Circulation Research. 78. 466-474 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsuoka,S.: "Multiple functional states of the cardiac Na^+-Ca^<2+> exchanger. Whole-cell,native-excised,and cloned-excised properties." Annals of the New York Academy of Sciences. 779. 159-170 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Nicoll,D.A.: "Mutation of amino acid residues in the putative transmembrane segments of the cardiac sarcolemmal Na^+-Ca^<2+> exchanger." J.Biol.Chem.271. 13385-13391 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hryshko,L.V.: "Anomalous regulation of the Drosophia Na^+-Ca^<2+> exchanger by Ca^<2+>" J.General Physiology. 108. 67-74 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Gou,J.: "Monovalent cation conductances of low-threshold and sustained inward current in rabit sinoatrial node cells." Pflugers Archiv. 433. 209-211 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Okazaki,N.: "Characteristics of the melibiose transport and its primary strucure in Enterobacter aerogenes." Biochim.Biophys.Acta. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Noumi,T.: "Identification and characterization of functional residues in a Na^+ / H^+ antiporter (NhaA) from Escherichia coli by randam mutagenesis." J.Biochem.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Sarker,R.I.: "Primary structure and properties of the Na^+ / glucose symporter (SgIS) of Vibrio parahaemolvticus." J.Bacteriol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,K.: "Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells trasdected with human MDR1" Biochem.Pharmacol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Yano,I.: "Evaluation of renal tubular secretion and reabsorption of levofloxacin in rats." Pharm.Res.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Kasahara,T.: "Characterization of rat Glut4 glucose transporter expressed in yeast Saccharomyces cerevisiae." Biochim.Bhiophys.Acta. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Takata,K.: "Transport of glucose across the blood-brain barriers." Int.Rev.Cytol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsuoka,S.: "Reglulation of the cardiac Na^+-Ca^<2+> exchanger by the endogenous XJP region." J.General Physiology. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Dunne,M.J.: "Familial persistent hyperinsulinemic hypoglycaemia of infancy,and mutations in the sulfonylurea receptor." New Engl.J.Med.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,J.: "Cellular distribution of the P2×4 ATP receptor mRNA in the brain and peripheral organs of rats." Arch.Histol.Cytol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshitomi,H.: "Involvement of MAP kinase / c-fos signaling in the inhibition of cell growth by somatostatin in insulinoma-derived cell." Am.J.Physiol.(in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] Inoue,H.: "Essential aspartic acid residues,Asp-133,Asp-163 and Asp-164,in the transmembrane helices of a Na^+/H^+ antiporter (NhaA) from E.coll." FEBS Letters. 363. 264-268 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohtani,K.: "Involvement of a protein kinase C in Ca2^+-signaling pathways to activation of AP-1 DNA-binding activity evoked via NMDA-" J.Neurochem.65. 605-614 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomita,Y.: "Transport of oral cephalosporins by the H^+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intesinal" J.Pharmacol.Exp.Ther.272(1). 63-69 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsumoto,S.: "Transport characteristics of ceftibuten,a new cephalosporin antibiotic,via the apical H^+/dipeptide cotransport system in the human intestinal" Pharm.Res.12. 1483-1487 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Saito,H.,: "Cloning and characterization of a rat H^+/peptide cotransporter mediating absorptoption of β-lactam antibiotics in the intestine" J.Pharmacol.Exp.ther.275(3). 1631-1637 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nagai,J.: "Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line" J.Pharmacol.Exp.ther.274(3). 1161-1166 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirai,M.: "Cepharantin,a multidrug resistant modifier,is a substrate for P-glycoprotein." J.Pharmacol.Exp.Ther.275(1). 73-78 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida,A.: "Immunohistochemical localization of Na^+-dependent glucose trasnporter in the rat digestive tract." Histochmical J.27. 420-426 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishizawa,K.: "Substrate recognition domain of the Gal2 galactose transporter in yeast Saccharomyses cerevisiae as revealed by chimeric galactose-" J.Biol.Chem.270. 2423-2426 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takigawa,T.: "Antibodies against GM1 ganglioside affect K^+ and Na^+ currents in isolated rat myelinated nerve fibers." Ann Neurology. 37. 436-442 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Guo,J.: "A sustained inward current activated at the diastolic potential range in rabbit sino-atrialnode cells." J.Physiology. 483. 1-13 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Manabe,K.: "Hyperpolarization induced by vasoactive substances in intact guinea-pig endocardial endothelial cells." J.Physiology. 484. 25-40 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Manabe,K.: "Classification of ion channels in the luminal and abluminal membranes of guinea-pig endocardial endothelial cells." J.Physiology. 484. 41-52 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Manabe,K.: "Non-selective cation current of guinea-pig endocardial endothelial cells." J.Physiology. 487. 407-419 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inagaki,N.: "Reconstitution of lKATP : An inward rectifier subunit plus the sulfonylurea receptor." Science. 270. 1166-1170 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inagaki,N.: "cDNA sequence,gene structure,and chromosomal localization of the human ATP-sensitive potassium channel,uKATP-1,Gene (KCNJ8)." Genomics. 30. 102-104 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamada,Y.: "Human gastric inhibitory polyeptide receptor : cloning of gene and cDNA." Genomics. 29. 773-776 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kuromi,H.: "A monitor of secretion from single pancreatic β-cells." Diabetes. 44. 1213-1217 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamada,Y.: "The structures of the human calcium channel α1 subunit (CACNL1A2) and β subnuit (CACNLB3) genes." Genomics. 27. 312-319 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Marqueze,B.: "Cellular localization of Synaptotagmin I,II,and III mRNAs in the central nervous system,pituitary and adrenal glands of the rat." J.Neurosci.15. 4906-4917 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inagaki,N.: "Expression and role of ionotropic glutamate recepters in pancreatic islet cells." FASEB.J. 9. 686-691 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inagaki,N.: "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues,including" J.Biol.Chem.270. 5691-5695 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Blondel,O.: "Inositol 1,4,5-trisphosphate recetpors,secretory grnules and secretion in endocrine and neuroendocrine cells." Trends Neurosci. 18. 157-161 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yorimitsu,K.: "Cloning and sequence of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2." Biochem.Biophys.Res.Commun.208. 721-727 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Jones,J.M.: "Synaptotagmin genes on mouse Chromosomes 1,7 and 10 and human Chromosome 19." Nammal.Genome. 6. 212-213 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Oho,C.: "Expression and complex formation of soluble N-ethyl-maleimide-sensitive factor attachment protein (SNAP) receptors in clonal rat" Neurosci.Lett.186. 208-210 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Seino,S: "CACN4,the major α1 subunit isoform of voltage-dependent calsium channels in pancreatic β-cells : α minireview of current progress." Diabetes Res.Clin.Pract.28. S99-S103 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] lhara,Y.: "Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic β-cells." Mol.Endocrinol.9. 121-130 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shin,Y.: "Reconstitution of the F_1-ATPase activty from purified α、β、γ and δ or ε subunits with glutathions S-transferase fused at their amino" Biochim.Biophys.Acta. 1273. 62-70 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sarker,R.l.: "Properties of a Na+/galactose (glucose) symport system in Vibrio parahaemolyticus." Biochim.Biophys.Acta. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Sarker,R.l: "Sequence of a Na+/glucose symporter gene and its flanking regions of Vibrio parahaemolyticus." Biochim.Biophys.Acta. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Kasahara,T.: "Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae." Biochemical.J.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ding W-G.: "A possible role of ATP-sensitive K^+ channel in determining the duration of spike-bursts in mouse pancreatic β-cells." Biochim.Biophys.Acta. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] He L-P.: "Glucagon induced Ca^<2+>-dependent increase of reduced pyridine nucleotides in mouse pancreatic β-cells." Biochim.Biophys.Acta. (in press).

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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