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Functional Development of Neural Circuits

Research Project

Project/Area Number 07279102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionOsaka University Graduate School of Medicine

Principal Investigator

TSUMOTO Tadaharu  Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 (50028619)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Toru  Waseda University School of Human Sciences. Professor, 人間科学部, 教授 (70046027)
OBATA Kunihiro  Okazaki NatI. Res. Inst., National Inst. For Physiological Science, Professor, 生理学研究所, 教授 (60013976)
MURAKAMI Fujio  Osaka University Graduate School of Engineering Science, Professor, 基礎工学研究科, 教授 (20089882)
IKENAKA Kazuhiro  Okazaki Nati. Res. Inst., National Inst. For Physiological Science. Professor, 生理学研究所, 教授 (00144527)
KAWAI Nobufumi  Jichi Medical School, Professor, 医学部, 教授 (00073065)
Project Period (FY) 1995 – 1998
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥90,100,000 (Direct Cost: ¥90,100,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 1997: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 1996: ¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 1995: ¥26,700,000 (Direct Cost: ¥26,700,000)
KeywordsBrain / Neural Circuits / Development / Neuron / Synapse / Differentiation / Growth / Plasticity / 長期増強
Research Abstract

This project addressed a question of how neural circuits are formed and functionally developed so as to execute the higher brain function. To elucidate mechanisms underlying the formation and functional development of neural circuits in the brain, we took multidisciplinary approaches in this project. Thus, a close collaboration among researchers with different methodologies was essential for success of this project. After such a collaboration among members of this research project, we succeeded in obtaining many excellent results which were published in top-rank international journals. In this fiscal year we have edited a report of their achievements including a list of their publications. This report has been sent to researchers who are working in related fields and the members of this research project.

Report

(6 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Hata, Y., Ohsima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monoculary deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20(RC57). 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, Y., Tsumoto, T. and Stryker, M.P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Allen, C., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columuns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20 (RC57). 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, Y., Tsumoto, T. and Stryker, M. P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E. R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Allen, C. N., Jiang, Z., Teshima, K., Darland, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hata, Y., Ohshima, M., Ichisaka, S., Wakita, M. et al.: "Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats"J. Neuroscience. 20 (RC57). 1-5 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kumura, E., Kimura, F., Taniguchi, N. and Tsumoto, T.: "Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex"J. Physiology (London). 524. 195-204 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hata, Y., Tsumoto, T. and Stryker, M. P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited"Neuron. 22. 375-381 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shirasaki, R., Katsumata, R. and Murakami, F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target"Science. 279. 105-107 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kojima, N., Ishibashi, H., Obata, K. and Kandel, E. R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Allen, C. N., Jiang, Z., Teshima, K., Darkand, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kinoshita,S.,Yasuda,H.,Taniguchi,N.et al.: "Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex." J.Neuroscience. 19. 2122-2130 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hata,Y.,Tsumoto,T.and Stryker,M.P.: "Selective pruning of active afferents when cat visual cortex is pharmacologically inhibited." Neuron. 22. 375-381 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shirasaki,R.,Katsumata,R.and Murakami,F.: "Change in chemoattractant responsiveness of developing axons at an intermediate target." Science. 279. 105-107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kojima,N.,Ishibashi,H.,Obata,K.and Kandel,E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methy1-D-aspartate receptor subunit 2B in fyn transgenic mice." Leaming & Memory. 5. 429-445 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miyakawa,T.,Yagi,T.,Kitazawa,H.,Yasuda,M.Kawai,N.et al.: "Fyn-Kinase as a determinant of ethanol sensitivity:Relation to NMDA receptor function." Science. 278. 698-701 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Allen,C.N.,Jiang,Z.,Teshima,K.,Darland,T.,Ikeda,M.et al.: "Orphanin-FQ(OFQ)modulates the activity of suprachiasmatic nucleus neurons." J.Neuroscience. 19. 2152-2160 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akaneya,T., Tsumoto,T., Kinoshita,S. and Hatanaka,H.: "Brain derived neurotrophic factor enhances long-term potentiation in rat visual cortex." J.Neurosci.17. 6707-6716 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kimura,F., Otsu,Y. and Tsumoto,T.: "Presynaptically silent synapses : Spontaneously active terminals without stimulus-evoked release demonstrated in cortical autapses." J.Neurophysiol.77. 2805-2815 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shirasaki,R., Katsumata,R. and Murakami,F.: "Differential chemoattractant sensitivity of commissural axons before and after crossing the floor plate." Science. 279. 105-107 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Saito,Y., Song,W.-J. and Murakami,F.: "Preferential termination of corticorubral axons on spine-like dendritic protrusions in developing cat." J.Neurosci.17. 8792-8803 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Miyakawa,T., Yagi,T., Kitazawa,H., Yasuda,M. Kawai,N. et al.: "Fyn-kinase as a determinant of ethanol sensitivity : Relation to NMDA receptor function." Science. 278. 698-701 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asada,H., Kawamura,Y. et al.: "Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase." Proc.Natl.Acad.Sci.USA. 94. 6496-6499 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akaneya,Y.,Tsumoto,T.and Hatanaka,H.: "Long-term depression blocked by brain derived neurotrophic factor in rat visual cortex." J.Neurophysiol.76. 4198-4201 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tamura,H.,Sato,H.,Katsuyama,N.,et al.: "Less segregated processing of visual information in V2 than in Vl of the monkey visual cortex." Europ.J.Neurosci.8. 300-309 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yasuda,H.,and Tsumoto,T.: "Long-term depression in visual cortex is associated with a lower rise of postsynaptic Ca2+ than LTP." Neurosci.Res.24. 265-274 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Murakami,F.,Nagisa,Y.,Saito,Y.,Higashi,S.,et al.: "Morphology of individual axons in crossed corticorubral projections in developing cats and effects of partial denervation." Dev.Neurosci.18. 162-173 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shirasaki,R.,Mirzayan,C.,Tessier-Lavigne,M.,et al.: "Guidance of circumferentially growing axons by netrin-dependent and independent floor plate chemotropism in the vertebrate brain." Neuron. 17. 1079-1088 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tsubokawa,H,,Oguro,K.,Robinsdon,H.P.C.,et al.: "Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CAl neurones of the gerbil followint transient forebrain ischaemia." J.Physiol.Lond.497. 67-78 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsu,Y.,Kimura,F.,Tsumoto,T.: "Hebbian induction of LTP in visual cortex: A perforated patch clamp study in cultured neurons." J. Neurophysiol.74. 2437-2444 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Torii,N.,Kamishita,Y.,Otsu,Y.and Tsumoto,T.: "An inhibitor for calcineurin, FK506 blocks induction of long-term depression in rat visual cortex." Neurosci. Lett.185. 1-4 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shirasaki,R.,Tamada,A.,Katsumata,R.et al.: "Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis." Neuron. 14. 961-972 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kim,C.S.,Nelson,T.J.,Yoshioka,T. et al.: "Alzheimer and β-amyloid-treated fibroblasts demonstrate a decrease in a memory associated GTP-binding protein, Cp20." Proc. Natl. Acad. Sci. USA. 92. 3060-3064 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ogawa,M. Miyata,T.,Nakajima,K.,Yagyu,K.,Seike,M.,Ikenaka,K.,et al.: "The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons." Neuron. 14. 899-912 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamagata,Y.,Obata,k.,et al.: "Increase in synapsin I phosphorylation implicates a presynaptic component in septal kindling." Neuroscience. 64. 1-4 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2019-02-15  

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