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Synthesis and Application of Intelligent interface System

Research Project

Project/Area Number 07305036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field 生物・生体工学
Research InstitutionThe University of Tokyo

Principal Investigator

FURUSAKI Shintaro  The University of Tokyo Graduate School of Engineering Professor, 大学院・工学系研究科, 教授 (40011209)

Co-Investigator(Kenkyū-buntansha) NAKAO Shin-ichi  The University of Tokyo Graduate School of Engineering Professor, 大学院・工学系研究科, 教授 (00155665)
OHYA Haruhiko  Yokohama National University Dept. of Material Science and Chem. Eng. Professor, 工学部, 教授 (40017950)
INUI Kenichi  Kyoto University Faculty of Pharmaceutical Science Professor, 医学部, 教授 (70034030)
TAKAKUWA Yuichi  Tokyo Women's Medical College Dept. of Biochemistry Professor, 教授 (40113740)
OHKI Kazuo  Tohoku University Faculty of Science Professor, 理学部, 教授 (80115394)
宮嶋 孝一郎  京都大学, 薬学部, 教授 (30025689)
野澤 義則  岐阜大学, 医学部, 教授 (10021362)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 1996: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1995: ¥8,700,000 (Direct Cost: ¥8,700,000)
Keywordsbiological membrane / synthetic membrane / recognition of materials / signal transmission / selective transport
Research Abstract

Cyclodextrin having molecular recognition function based on bioaffinity were introduced into reverse micelles, and selective extraction of glucoamylase from alpha-amylase was succeeded.
Molecular imprint method has been applied to introduce amino-acid like structure into synthetic membrane and the membrane having recognition ability for optical isomers could be developed. Inorganic ion exchange membranes which recognized Li ion were prepared and the membranes selectively transpoeted Li ion.
Using cDNA cloning technique, structure and selective transport property of peptide and organic ion transporters were made clear. Thermosensitive gating function could be introduced into polymeric membrane and on-off operation of water permeation and selective transport and concentration of surfactant were succeeded.
Functional molecules which can transform external information and energy to internal change of electron state and structure were introduced into conductive polymer matrix, and information and energy conversion membranes could be synthesized.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] S.Furusaki et al.: "Extraction of Glucoamylase Using Reversed Micelles Incorporating Cyclodextrin" Proceedings of The 1996 International Congress on Membranes and Membrane Process. 682-683 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Takahashi,T.Yasue,K.Ohki,I.Hatta: "Structure and phase behavior of dimyristoylphosphatidic acid/poly (L-lysine) systems" Molecular Membrane Biology. (印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高桑雄一: "溶血性貧血における赤血球膜細胞骨格構造の変化" 日本臨床. 54,9. 2-5 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito,S,Masuda,and K.Inui: "Cloning and functional chracterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney" J.Biol.Chem. 271. 20719-20725 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Ohya et al.: "Characteristics of a zirconia composite membrave fabricated by alaser firing method" J.Membrane Sci.110. 249-252 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Yamaguchi,S.Nakano,S.Kimura: "Evidence and Mechanisms of Filling Polymerization by Plasma-Induced Graft Polymerization" J.Polym.Sci.,Polym.Chem.Ed.34. 1203-1208 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Furusaki et al.: "Extraction of Glucoamylase Using Reversed Micelles Incorporating Cyclodextrin" Proceedings of the 1996 International Congress on Membranes and Membrane Process. 682-683 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Takahashi, T.Yasue, K.Ohki, I.Hatta: "Structure and phase behavior of dimyristoylphosphatidic acid/poly (L-lysine) systems" Molecular Membrane Biology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuichi Takakuwa: "Changes in the structure of erythrocyte membrane skeleton in hemolytic anemia" The Japanese Journal of Clinical Medicine. 54,9. 2-5 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito, S.Masuda, and K.Inui: "Cloning and functional characterization of a novel rat organic anion tansporter mediating basolateral uptake of methotrexate in the kidney" J.Biol. Chem.271. 20719-20725 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Ohya et al.: "Characteristics of a zirconia composite membrave habricated by alaser firing method" J.Membrane Sci.110. 249-252 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Yamaguchi, S.Nakao, S.Kimura: "Evidence and Mechanisms of Filling Polymerization by Plasma-Induced Graft Polymerization" J.Polym. Sci., Polym. Chem. Ed.34. 1203-1208 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Furusaki et al.: "Extraction of Glucoamylase Using Reversed Micelles Incorporating Cyclodextrin" Proceedings of The 1996 International Congress on Membranes and Membrane Process. 682-683 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Takahashi,T.Yasue,K.Ohki,I.Hatta: "Structure and phase behavior of dimyristoylphosphatidic acid/poly(L-lysine)systems" Molecular Membrane Biology. (印刷中). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高桑雄一: "溶血性貧血における赤血球膜細胞骨格構造の変化" 日本臨床. 54,9. 2-5 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Saito,S,Masuda,and K.Inui: "Cloning and functional chracterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney" J.Biol.Chem.271. 20719-20725 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Ohya et al.: "Characteristics of a zirconia composite membrave fabricated by alaser firing method" J.Membrane Sci.110. 249-252

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Yamaguchi,S.Nakao,S.Kimura: "Evidence and Mechanisms of Filling Polymerization by Plasma-Induced Graft Polymerization" J.Polym.Sci.,Polym.Chem.Ed.34. 1203-1208 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S. Harsa and S. Furusaki: "Bioaffinity Adsorption Behavior of Several Enzymes onto β-Cyclodextrin-Chitosan" Sep. Sci. Technol.30. 2695-2706 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Ohki et al.: "Structural Characterization of the Complex in which Poly (L-lysine) with β-Sheet Conformation is Intercalated between Dimyristoylphosphatidic Acid Bilayers" Biophys. J.69. 1464-1472 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] S. Nakao et al.: "Transport of Organic Electrolytes with Electrostatic and Steric-Hindrance Effects through Nanofiltration Membranes" J. Chem. Eng. Japan. 28. 372-380 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Miyajima et al.: "Disposition Kinetics of Liposomes Modified with Synthetic Aminoglycolipids in Rats" Int. J. Pharm.115. 183-191 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Takakuwa et al.: "Modulation of Erythrocyte Membrane mechanical Function by β-Spectrin Phosphorylation and Dephosphorylation" J. Biol. Chem.270. 5659-5665 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Inui et al.: "Specificity of p-Aminohippurate Transport System in the OK Kidney Epithelial Cell Line" J. Pharmacol Exp. Ther.274. 1161-1166 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2018-02-02  

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