• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Therapeutic Evaluation in Cardio-and Cerebrovascular Disease by Using Positron Emission Tomography

Research Project

Project/Area Number 07307012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

NISHIMURA Tsunehiko  Osaka University Medical School Professor, 医学部, 教授 (70237733)

Co-Investigator(Kenkyū-buntansha) YONEKURA Yoshiharu  Fukui Medical School Professor, 医学部, 教授 (60135572)
SASAKI Yasuhito  Tokyo University, Medical School Professor, 医学部, 教授 (80081694)
OCHI Hironobu  Osaka City University, Medical School Professor, 医学部, 教授 (70047067)
KONISHI Junji  Kyoto University, Medical School Professor, 医学部, 教授 (70026970)
UEHARA Toshiisa  Osaka University Hospital Lecturer, 医学部・附属病院, 講師 (80243202)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1996: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsPositron Emission Tomography / Cardiovascular Disease / Cerebrovascular Disease / Therapeutic Evaluation / Tracer Kinetics / 心不全 / 脳血管性痴呆
Research Abstract

It is important to evaluate therapeutic effects in cardio-and cerebrovascular disease by using positron emission tomography (PET). The co-investigators developed the new evaluation method related to the therapeutic effects. In this study, we completed the following items.
1.We developed new PET tracers for cardio and cerebrovascular disease. Based on these data, we performed basic research using animal model for metabolic and receptor mapping (Maeda and Watanabe).
2.We performed cardiac PET study in patients with ischemic heart disease and heart failure. We demonstrated the therapeutic effects of percutaneous transcatheter coronary angioplasty and beta-blocker therapy from the viewpoint of myocardial ischemia and viability by using ^<18>F-FDG,^<13>NH_3 and ^<11>C-acetate PET study (Ochi and Konishi).
3.We performed brain PET study in patients with cerebrovascular disease and dementia. We demonstrated the therapeutic effects of bypass surgery and anti-dementia therapy from the viewpoint of cerebral blood flow and metabolism by using H_2^<15>O and gas study (Sasaki and Yonekura).
4.We developed a new evaluation system of therapeutic effects by quantitative PET parameters related to flow, metabolism and receptor (Nishimura and Uehara).
Our study demonstrated that PET study in evaluating the therapeutic effects of cardio-and cerebrovascular disease in very useful from the viewpoint of basic research and clinical application.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Katsuji Hashimoto: "Paradoxical uptake of F-18 fluorodeoxyglucose by successfully reperfused myocardium during the sub-acute phase in patients with acute myocardial infarctic" Annals of Nuclear Medicine. 10. 93-98 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Eiji Tadamura: "Myocardial Metabolic Changes in Hypertrophic Cardiomyopathy." The Journal of Nuclear Medicine. 37. 572-577 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yasuhisa Sakurai: "Activation of preffontal and posterior superior temporal areas in visual caluculation." Journal of the Neurological Sciences. 139. 89-94 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fumi Nagatsuji: "20-18F-Fluoroarachidonic Acid : Tissue Biodistribution and Incorporation into Phospholipids." Biol Pharm bull. 19. 1316-1321 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazuhiko Yanai: "Positron Emission Tomographic Study of Central Histamine Hl-Receptor Occupancy in Human Subjects Treated with Epinastine, a Second-Generation Antihistamine." Meth Find Exp Clin Pharmacol. 17. 64-69 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshiharu Yonekura: "Brain Perfusion SPECT with 99m-Tc-Bicisate : Comparison with PET Measurement and Linearization Based on Permeability-Surface Area Product Model." Journal of Cerebal Blood Folw and Metabolism. 14. 58-65 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuji Hashimoto: "Paradoxical uptake of F-18 fluorodeoxyglucose by successfully reperfused myocardium during the sub-acute phase in patients with acute myocardial infarctic" Annals of Nuclear Medicine. 10. 93-98 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Eiji Tadamura: "Myocardial Metabolic Changes in Hypertophic Cardiomyopathy." The Journal of Nuclear Medicine. 37. 572-577 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yasuhisa Sakurai: "Activation of prefrontal and posterior superior temporal areas in visual caluculation." Journal of the Neurological Sciences. 139. 89-94 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fumi Nagatsuji: "20-18F-Fluoroarachidonic Acid:Tissue Biodistribution and Incorporation into Phospholipids." Biol Pharm bull. 19. 1316-1321 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazuhiko Yanai: "Positron Emission Tomographic Study of Central Histamine Hl-Receptor Occupancy in Human Subjects Treated with Epinastine,a Second-Generation Antihistamine." Meth Find Exp Clin Pharmacol. 17. 64-69 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshiharu Yonekura: "Brain Perfusion SPECT with 99m-Tc-Bicisate:Comparison with PET Measurement and Linearization Based on Permeability-Surface Area Product Model." Journal of Cerebal Blood Flow and Metabolism. 14. 58-65 (1994)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi