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Basic and clinical aspect of immune-mediated inner ear disorders

Research Project

Project/Area Number 07307031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Otorhinolaryngology
Research InstitutionOita Medical University

Principal Investigator

MOGI Goro  Dept.of Otolaryngology, Oita Med.Univ., Professor, 医学部, 教授 (20035190)

Co-Investigator(Kenkyū-buntansha) KAWAUCHI Hideyuki  Dept.of Otolaryngology, Shimane Med.Univ., Professor, 医学部, 教授 (50161279)
KANZAKI Jin  Dept.of Otolaryngology Sch.of Med., Keio Univ., Professor, 医学部, 教授 (00051441)
TAKASAKA Tomonori  Dept.of Otolaryngology, Tohoku Univ.Sch.of Med., Professor, 医学部, 教授 (80004646)
NAKAI Yoshiaki  Dept.of Otolaryngology, Osaka City Univ.Med.Sch., Professor, 医学部, 教授 (10046998)
YANAGITA Noriyuki  Dept.of Otorhinolaryngology, Sch of Med., Nagoya Univ., Professor, 医学部, 教授 (00023804)
高橋 光明  旭川医大, 医学部, 講師 (50094652)
富山 俊一  日本医大, 医学部, 助教授 (00094665)
久保 武  大阪大学, 医学部, 教授 (30107031)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1996: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsautoimmune diseases / PCR (polymerase chain reaction) / HLA (human leukocyte antigen) / adhesion molecule / Na, K-ATPase / spiral ligament / endolymphatic sac / anaphylaxis / ステロイド依存性難聴 / HLA (human leukocyte antigen) / PCR法 / ICAM-1 / 血液-内耳関門 / 内リンパ曩 / 増殖期細胞 / フリーラジカル / 血管条
Research Abstract

A.Clinical Studies
(1) The clinical features of steroid-responsive sensorineural hearing loss and acute sensorineural hearing loss with autoimmune diseases were investigated.
(2) Using a RT-PCR technique, the measles virus was detected in perilymph taken during cochlear implant surgery in patients with profound hearing loss.
(3) The frequency of HLA-Aw33 in otosclerosis patients was higher than that in the control subjects.
B.Basic Studies
(1) Secondary antigen challenge into the endolymphatic sac resulted in the cellular migration and ICAM-1 expression in the whole inner ear venules, suggesting that chemical mediators produced within the endolymphatic sac may spread into all compartments of the inner ear and lead to immunological defense and injury of the inner ear.
(2) Inner ear responses to foreign cells induced activation and invasion of natural killer cells which occur relatively late compared with those in other organs.
(3) Decreased immunoreactivity for Na, K-ATPase and connexin 26 was observed in the spiral ligament after immune injury.
(4) Study of cell proliferation revealed that the epithelium of the endolymphatic sac can regenerate after immune injury.
(5) Repeated antigen challenges into the inner ear caused an anaphylactic reaction that may disturb hearing and equilibrium.
(6) MRL/prmouse and NZB mouse were studied electrophysiologically and histopathologically to clarify the mechanism by which autoimmune inner ear diseases occur.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] 一宮一成,茂木五郎: "内耳免疫傷害動物の病理組織" Otol Jpn. 6(3). 170-176 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamane,T.Nakagawa,Y.Nakai et al.: "In vivo regeneration of vestibular hair cells of guinea pig." Acta Otolaryngol (Stockh). S520. 174-177 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 神崎 仁: "免疫異常に関連する感音難聴-厚生省調査研究班診断基準(案)の見直しと今後の問題点-" Otol Jpn. 6(3). 151-156 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 富山俊一 他: "内耳免疫現象の基礎的研究・内リンパ嚢局所抗原刺激における内耳初期免疫動態" Otol Jpn. 6(3). 163-169 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Takahashi,S.Tomiyama: "Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation." Acta Otolaryngol. S115. 396-399 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Takahashi,S.Tomiyama: "Regeneration of the damaged endolymphatic sac epithe lium" Laryngoscope. 106(5). 619-623 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 神崎 仁: "免疫異常による感音難聴をどのように診断するか 耳鼻咽喉科頭頚部外科クリニカルトレンド" 中山書店,野村恭也,本庄 巌,平出文久 編, 285 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 富山俊一: "内耳自己免疫病の免疫学的検査 耳鼻咽喉科疾患への免疫学的アプローチ" メジカルビュー社,茂木五郎編, 234 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamane, T.Nakagawa, Y.Nakai et al.: "In vivo regeneration of vestibular hair cells of guinea pig" Acta Otolaryngol (Stockh). Suppl.520. 174-177 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamane, Y.Nakai, T.Takayama et al.: "Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma" Eur Arch Otorhinolaryngol. 252. 504-508 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Tomiyama, T.Kinoshita, T.Yagi et al.: "Fluctuating hearing loss following immune reaction in the endolymphatic sac of guinea pigs" ORL Relat Spec. 57(3). 122-128 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Jinnouchi, S.Tomiyama: "Distribution of endothelin-1 like activity in the endolymphatic sac of normal guinea pigs." Acta Otolaryngol (Stockh). 115(6). 400-404 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Takahashi, S.Tomiyama: "Cell proliferation in the endolymphatic sac in situ after inner ear immunostimulation." Acta Otolaryngol (Stockh). 115. 396-399 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Takahashi, S.Tomiyama: "Regeneration of the damaged endolymphatic sac epithelium." Laryngoscope. 106(5). 619-623 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] R.Minoda, K.Masuyama, T.Toriya, K.Uno, M.Eura, T.Ishikawa: "Recurrent Hearing Impaiment and Nystagmus Induced by Repeated Antigen Exposure in Actively Sensitized Guinea Pigs" Int Arch Allergy Immunol. 111. 116-172 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Miyazawa, C.Tago, H.Ueda, H.Niwa, N.Yanagita: "HLA associations in otosclerosis in Japanese patients" Eur Arch Otorhinolaryngol. 253. 501-503 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Ichimiya, Y.Kurono, T.Hirano, G.Mogi: "Changes in immunostaining of inner ears after antigen challenge into the scala tympani" Laryngoscope. (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 一宮一成,茂木五郎: "シンポジウム「内耳における免疫現象」特集:内耳免疫傷害動物の病理組織" Otol Jpn. 6(3). 170-176 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Kanzaki: "Acute profound deafiness" Asian Med J. 36. 66-72 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 神崎 仁: "免疫異常に関連する感音難聴-厚生省調査研究班診断基準(案)の見通しと今後の問題" Otol Jpn. 6. 151-156 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Jinnouchi, S.Tomiyama: "Distribution of endothelin-1 like activity in the vestibule of normal guinea pigs." ORL Relat Spec. 58(1). 4-8 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 富山俊一 他: "内耳免疫現象の基礎的研究.内リンパ嚢局所抗原刺激における内耳初期免疫動態" Otol Jpn. 6(3). 163-169 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Takahashi, S.Tomiyama: "Regeneration of the damaged endolymphaticsac epithelium" Laryngoscope. 106(5). 619-623 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 神崎 仁: "免疫異常による感音難聴をどのように診断するか 耳鼻咽喉科頭頚部外科クリニカルトレンド" 中山書店,野村恭也,本庄 巌,平出文久編, 285 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 富山俊一: "内耳自己免疫病の免疫学的検査 耳鼻咽喉科疾患への免疫学的アプローチ" メジカルビュー社,茂木五郎編, 234 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Machihiko Sone Noriyuki Yanagita et al.: "A substrain of NZB mouse as an animal model of autoimmune inner ear disease" Hearing Research. 83. 26-36 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mitsuaki Takahashi et al.: "Cell Prolifcration in the Endolymphatic Sac in situ after Inner Ear Immunostimulation" Acta Otolaryngol (Stockh). 115. 396-399 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yamane Y.Nakai et al.: "Natural killer cell response in the inner ear." Acta Otolaryngol (Stockh). 115. 738-741 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yamane Y.Nakai et al.: "In vivo regeneration of vestibular hair cells of guinea pig" Acta Otolaryngol (Stockh). S520. 174-177 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yamane Y.Nakai et al.: "Appearance of free radicals in the guinea pig inner ear after nise-induced acoustic trauma" Eur Arch Otorhinolaryngol. 252. 504-508 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] S.Tomiyama et al.: "Fluctuating hearing loss following immune reaction in the endolymphatic sac of guinea pigs" ORL Relat Spec. 57. 122-128 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hideyuki Kawauchi: "Is endolymohatic sac (ELsac) categorized as the mucosa associated lymphoid tissue (MALT) ?-A brief review on this issue-" Proc.Sendai Symposium. 5. 21-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 蓑田涼生、宇野研吾 他: "能動感作内耳I型アレルギーモデルにおける抗原投与後の聴力変動と眼振の出現について" Equilibrium research. 55(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 神崎 仁: "ステロイド依存性難聴-突発性難聴との鑑別-" Otol Jpn. 4(2). 146-153 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tomonori Takasaka et al.: "Strial dysfunction caused by immune injury : apossible pathogenesis of immune-induced sensorineural hearing loss" Immunobiology in otorhinolaryngology progress of a decarde ed : G.Mogi,J.E.Veldman and H.Kawauchi Kugler Publications,pp.175-179,674 (1994)

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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