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Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics

Research Project

Project/Area Number 07307035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Physical pharmacy
Research InstitutionKanazawa University

Principal Investigator

TSUJI Akira  Kanazawa University, Pharmaceutics, Professor, 薬学部, 教授 (10019664)

Co-Investigator(Kenkyū-buntansha) MAYUMI Tadanori  Osaka University, Pharmaceutics, Professor, 薬学部, 教授 (00098485)
HASHIDA Mitsuru  Kyoto University, Pharmaceutics, Professor, 薬学部, 教授 (20135594)
SUGIYAMA Yuichi  University of Tokyo, Pharmaceutics, Professor, 薬学部, 教授 (80090471)
AWAZU Shoji  Tokyo University of Pharmacy and Life Science, Pharmaceutics, Professor, 薬学部, 教授 (60012621)
HANANO Manabu  Nihon University, Pharmaceutics, Professor, 薬学部, 教授 (60012598)
山本 郁男  北陸大学, 薬学部, 教授 (50069746)
渡辺 淳  名古屋市立大学, 薬学部, 教授 (80080175)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1996: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordsdrug delivery / transporter / receptor / efflux pump / tissue targeting / pharmacokinetics / blood-brain barrier / cloning / efflux pump / ドラッグデリバリー / トランスポーター / レセプター / 組織標的化 / 薬物速度論
Research Abstract

The purpose of this research project is to clarify the organ specific transports of drugs from the view points of organ, cell, molecular and gene levels and to develop novel method for regulation of pharmacokinetics and pharmacodynamics of drugs. The following results were obtained by two years term of this research project consisted of 14 investigators :
1.Several evidences were obtained for molecular and biological characteristics of transporters involved in the buccal and intestinal absorption and secretion, renal secretion and reabsorption, hepatic uptake and biliary secretion and in the brain influx and efflux transports. Cloning of transporters of PepT1, PepT2, MCT1, cMOAT,OAT-K1 and OCT2, their transport functions and tissue distribution were clarified. It was also clarified that P-glycoprotein functions as the transport barrier for lipophilic xenobiotics in the intestine and at the blood-brain barrier (BBB). Peptides were confirmed to be taken up by adsorptive-mediated endocytos … More is at the BBB to be delivered into the brain. 2.Improvement of absorption for drugs was achieved by glycosylation, endocytosis across Peyer's patches, iontophoretic method and by absorption enhancers to open tight junction. 3.Uptake of fractionated heparin by hepatocytes and Kupffer cells was clarified to be regulated by the scavenger receptor-mediated and plasma proteins-mediated mechanisms. Liver-specific delivery of drugs, proteins and gene was achieved by using galactosylated technology. Reactive oxygen species, such as superoxide and nitric oxide (NO), were clarified to play critical roles in the pathogenesis of various diseases. To overcome the oxidative stress, synthesized site-directed SOD derivatives were succeeded to deliver the targeting cells. An attractive approach for the antibody-based therapy of solid tumors was proposed and evaluated successfully by use of "vascular targeting" antibody to recognize tumor endothelial cells. 4.Using alpha 1-adrenoreceptor as a model, cloning of the receptors and detection of the tissue localization of the receptor protein were succeeded. It was indicated that uridine receptor plays some role not only in brain but also in peripheral tissues. Pharmacokinetic and pharmacodynamic behaviors for the transport in the brain, receptor binding and analgesic action were analyzed after peptazocine administration in rats. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (355 results)

All Other

All Publications (355 results)

  • [Publications] T. Ohnishi: "In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier" Biochem. Pharmacol.49. 1541-1544 (1995)

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      1996 Final Research Report Summary
  • [Publications] I. Tamai: "Na^+ and Cl^- -dependent transport of taurine at the blood-brain barrier" Biochem. Pharmacol.50. 1783-1793 (1995)

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  • [Publications] H. Takanaga: "cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter" Biochem. Biophys. Res. Commun.217. 370-377 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Terasaki: "Hepatic uptake of octeotide, a long-acting somatostatin analogue, via a bile acid transport system" Pharm. Res.12. 12-17 (1995)

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      1996 Final Research Report Summary
  • [Publications] I. Tamai: "Functional expression of transporter for β-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines" J. Pharmacol. Exp. Ther.273. 26-31 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Minagawa: "Species differences in hydrolysis of isocarbacyclin methyl ester (TEI9090) by blood esterases" Biochem. Pharmacol.49. 1361-1366 (1995)

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      1996 Final Research Report Summary
  • [Publications] I. Tamai: "Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids" Biochem. Biopyhys. Res. Commun.214. 482-489 (1995)

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  • [Publications] I. Tamai: "Proton-cotransport of pravastatin across intestinal brush-border membrane" Pharm. Res.12. 1727-1732 (1995)

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      1996 Final Research Report Summary
  • [Publications] 玉井郁巳: "ジペプチドトランスポーターと医薬品の消化管吸収" ファルマシア. 31. 493-497 (1995)

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      1996 Final Research Report Summary
  • [Publications] 辻 彰: "薬物相互作用-P糖蛋白質" ファルマシア. 31. 997-1001 (1995)

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      1996 Final Research Report Summary
  • [Publications] S. Matsumoto: "Transport characteristics of ceftibuten, a new cephalosporin antibiotic, via the apical H^+/dipeptide cotransport system in the human intestinal cell line Caco-2 : Regulation by cell growth." Pharm. Res.12 (10). 1483-1487 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Hirai: "Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein" J. Pharmacol. Exp. Ther.275 (1). 73-78 (1995)

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  • [Publications] Y. Tomita: "Transport of oral cephalosporins by the H^+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells" J. Pharmacol. Exp. Ther.272 (1). 63-69 (1995)

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      1996 Final Research Report Summary
  • [Publications] J. Nagai: "Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line" J. Pharmacol. Exp. Ther.274 (3). 1161-1166 (1995)

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      1996 Final Research Report Summary
  • [Publications] H. Saito: "Cloning and characterization of a rat H^+/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney" J. Pharmacol. Exp. Ther.275 (3). 1631-1637 (1995)

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      1996 Final Research Report Summary
  • [Publications] K. Iwata: "High-performance liquid chromatographic determination of diadenosine 5′,5′″-p1, p4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in whole blood" J. Chromatogr. B.667 (2). 339-343 (1995)

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      1996 Final Research Report Summary
  • [Publications] K. Iwata: "Ca^<2+> Dependency of diadenosine 5′, 5′″-p1, p4-tetraphosphate degradation in dog plasma" Biol. Pharm. Bull.18 (5). 788-790 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Nakagawa: "Biopharmaceutical studies on drug/conjugated-metabolite interactions. I. Fate of acetaminophen sulfate, a major conjugated metabolite of acetaminophen, in rats" Int. J. Pharm.121 (1). 55-63 (1995)

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      1996 Final Research Report Summary
  • [Publications] Z. Wang: "Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract" Biol. Pharm. Bull.18 (9). 1238-1241 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Kimura: "Disposition of diadenosine 5′, 5′″-p1, p4-tetraphosphate (Ap4A) in rats" Biol. Pharm. Bull.18 (11). 1556-1559 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Kimura: "プロドラッグによるAzidothymidineの脳移行性改善" DDS. 10 (6). 413-417 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Nishikawa: "Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties" Am. J. Physiol.268 (5). G849-G856 (1995)

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  • [Publications] M. Nishikawa: "Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism : effect of molecular weight of proteins on targeting efficiency" Pharm. Res.12 (2). 209-214 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Hashida: "Hepatic targeting of drugs and proteins by chemical modification" J. Control. Release. 36 (1-2). 99-107 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Motoya: "糖鎖認識機構を利用した細胞特異的薬物ターゲティング(Cell-specific targeting of drugs utilizing sugar-recognition systems)" Pharm. Tech. Japan. 11 (4). 395-403 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells" J. Pharmacol. Exp. Ther.272 (2). 739-743 (1995)

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      「研究成果報告書概要(和文)」より
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      1996 Final Research Report Summary
  • [Publications] T. Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. Kimura: "Binding affinity of N^3-substituted uridine for synaptic membrance and their CNS depressant effects" Nucleic Acids Symposium Series. 34. 147-148. (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Haba: "Uptake mechanism of fractionated ^3H-heparin by isolated rat kupffer cells" Xenobio. Metabol. Dispos.10 (suppl. s104-107 (1995)

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      1996 Final Research Report Summary
  • [Publications] 掛江敦之: "血液脳関門-静的障壁からダイナミック・インターフェースへ-脳へのドラッグデリバリーの最近の進歩-その4-" Pharm. Tech. Japan. 11. 23-25 (1995)

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      1996 Final Research Report Summary
  • [Publications] M. Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells" J. Pharmcol. Exp. Ther.272. 739-743 (1995)

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      1996 Final Research Report Summary
  • [Publications] Y. Takehara: "Oxygen dependent regulation of mitochondrial functions by nitric oxide" Arch. Biochem. Biophys.323 (1). 27-32 (1995)

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      1996 Final Research Report Summary
  • [Publications] I. Matsuoka: "Impact of erythrocytes on mouse embryonal development in vitro" FEBS Lett.371. 297-299 (1995)

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      1996 Final Research Report Summary
  • [Publications] Z. Radak: "Superoxide dismutase derivative prevents the exhaustive exercise induced oxidative damage in liver and kidney of rats" J. Applied Physiol.79. 129-135 (1995)

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  • [Publications] S. Kawamoto: "Changes in the circulatory status and transport functions of the liver induced by reactive oxygen species" Am. J. Physiol.268. G47-G53 (1995)

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      1996 Final Research Report Summary
  • [Publications] Y. Nishimura: "Inhibition of puromycin-induced renal injury by a superoxide dismutase with prolonged half-life in the circulation" Nephron. 70. 460-465 (1995)

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  • [Publications] K. Ono: "A negative chronotropic effect of endothelin-1 mediated through ETA receptor in guinea pig atria" Circ. Res.76. 284-292 (1995)

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  • [Publications] T. Kuwabara: "Receptor-mediated clearnance of G-CSF derivative nartograstim in bone marrow of rats" Am. J. Physiol.269. E1-E9 (1995)

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  • [Publications] T. Kuwabara: "Saturable uptake of a recombinant human granulocyte colony stimulating factor derivative nartograstim by the bone marrow and spleen of rats in vivo" J. Pharmacol. Exp. Ther.273. 1114-1122 (1995)

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  • [Publications] H. Takikawa: "Binding of lithocholate and its glucuronide and sulfate by human serum albumin" Biochem. Biophys. Acta. 1244. 277-282 (1995)

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      1996 Final Research Report Summary
  • [Publications] Ke-Xin. Liu: "Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats" Am. J. Physiol.269. G1-G9 (1995)

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      1996 Final Research Report Summary
  • [Publications] A. Hirasawa: "Cloning, functional expression and tissue distribution of human α 1c-adrenoceptor splice variants" FEBS Lett.363. 256-260 (1995)

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      1996 Final Research Report Summary
  • [Publications] T. A. Esbenshade: "Cloning of the human α 1A/D-adrenergic receptor and inducible expression of three human subtypes in SKNMC cells" Mol. Pharmacol.47. 977-985 (1995)

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      1996 Final Research Report Summary
  • [Publications] K. Horie: "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α 1-adrenoceptor subtypes" Brit. J. Pharmacol.116. 1611-1618 (1995)

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  • [Publications] K. Shibata: "KMD-3213, a novel, potent α 1a-adrenoceptor-selective antagonist : Characterization using recombinant human α 1-adrenoceptors and native tissues" Mol. Pharmacol.48. 250-258 (1995)

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      1996 Final Research Report Summary
  • [Publications] N. Utoguchi: "Effect of tumor cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen" Brit. J. Cancer. 73 (1). 24-28 (1996)

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      1996 Final Research Report Summary
  • [Publications] H. Mizuguchi: "Glial conditioned medium elevates alkaline phosphatase activity in cultured bovine aortic endothelial cells" Microvasular Res.50. 129-132 (1995)

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  • [Publications] Y. Tsutsumi: "Molecular design of hybrid tumor necrosis factor-α with polyethylene glycol increases its anti-tumor potency" Brit. J. Cancer. 71. 963-968 (1995)

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      1996 Final Research Report Summary
  • [Publications] N. Utoguchi: "Isolation and properties of tumor-derived endothelial cells from rat KMT-17 fibrosarcoma" Jpn. J. Cancer Res.86. 193-201 (1995)

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      1996 Final Research Report Summary
  • [Publications] N. Utoguchi: "Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayer" Cancer Lett.89. 7-14 (1995)

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  • [Publications] T. Kimura: "Central nervous system depressant effects of N^3-substituted derivatives of deoxyuridine in mice" Biol. Pharm. Bull.19 (1). 142-145 (1996)

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      1996 Final Research Report Summary
  • [Publications] T. Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

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      1996 Final Research Report Summary
  • [Publications] J. Watanabe: "Uptake of fractionated ^3H-heparin by isolated rat Kupffer cells" Pharm. Res.12. 1092-1095 (1995)

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      1996 Final Research Report Summary
  • [Publications] J. Watanabe: "Uptake of low molecular weight fractionated [^3H]heparin by rat hepatocytes in the primary culture" Biol. Pharm. Bull.18. 443-446 (1995)

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  • [Publications] Y. Sai: "Immunolocarization and pharmacological relevance of oligopeptide transporter Pep T1 in intestinal absorption of β-lactam antibiotics" FEBS Lett.392 (1). 25-29 (1996)

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  • [Publications] J. Komura: "Na^+ and Cl^- dependent transport of β-alanine across the blood-brain barrier" J. Neurochem.67 (1). 330-305 (1996)

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  • [Publications] K. Miyamoto: "Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter" Biochim. Biophys. Acta. 1305 (1). 34-38 (1996)

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  • [Publications] A. Tsuji: "Carrier-mediated intestinal transport of drugs" Pharm. Res.13 (7). 963-977 (1996)

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  • [Publications] I. Tamai: "Carrier-mediated approaches for oral drug delivery" Adv. Drug Delivery Rev.20. 5-32 (1996)

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  • [Publications] I. Tamai: "Drug delivery through the blood-brain barrier" Adv. Drug Delivery Rev.19. 401-424 (1996)

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  • [Publications] T. Ogihara: "Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells" Pharm. Res.13 (12). 1828-1832 (1996)

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  • [Publications] T. Terao: "Active secretion of drugs from the small intestinal epithelium in rats by Pglycoprotein functioning as as absorption barrier" J. Pharm. Pharmacol.48. 1083-1089 (1996)

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  • [Publications] T. Minagawa: "Blood-brain-barrier transport of lipid microspheres containing clinoprost, a prostaglandin I2 analogue" J. Pharm. Phamacol.48. 1016-1022 (1996)

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      1996 Final Research Report Summary
  • [Publications] M. Tomita: "Absorption-enhancing mechanism of EDTA, caprate, and decanyolcarnitine in Caco-2 cells" J. Pharm. Sci.85 (6). 608-611 (1996)

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      1996 Final Research Report Summary
  • [Publications] T. Ohtomo: "Transport of levofloxacin in a kidney epithelial cell line, LLC-PK1 : Interaction with organic cation transporters in apical and basolateral membranes" J. Pharmacol. Exp. Ther.276 (3). 1143-1148 (1996)

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      1996 Final Research Report Summary
  • [Publications] H. Ogihara: "Immuno-localization of H^+/peptide cotransporter in rat digestive tract" Biochem. Biophys. Res. Commun.220 (3). 848-852 (1996)

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      1996 Final Research Report Summary
  • [Publications] H. Saito: "Molecular cloning and tissue distribution of rat peptide transporter PEPT2" Biochim. Biophys. Acta. 1280 (2). 173-177 (1996)

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  • [Publications] K. Tanaka: "Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein" Pharm. Res.13 (7). 1073-1077 (1996)

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      1996 Final Research Report Summary
  • [Publications] T. Nabekura: "Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes" Pharm. Res.13 (7). 1069-1072 (1996)

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  • [Publications] M. Okuda: "cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2" Biochem. Biophys. Res. Commun.224 (2). 500-507 (1996)

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      1996 Final Research Report Summary
  • [Publications] H. Saito: "Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney" J. Biol. Chem.271 (34). 20719-20725 (1996)

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      1996 Final Research Report Summary
  • [Publications] M. Takano: "Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells" Am. J. Physiol.271 (2). F469-F475 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Nabekura: "Cholesterol modulates organic cation transport activity and lipid fluidity in rat renal brush-border membranes" Biochim. Biophys. Acta. 1283 (2). 232-236 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Terada: "Identification of the histidine residues involved in substrate recognition by a rat H^+/peptide cotransporter, PEPT1" FEBS Lett.394 (2). 196-200 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H. Saito: "Na^+-Dependent uptake of 1, 5-anhydro-D-glucitol via the transport systems for D-glucose and D-mannose in kidney epithelial cell line, LLC-PK1" Jpn. J. Nephrol.38 (10). 435-440 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Nishikawa: "Oxygen-Dependent Regulation of Ascites Tumor Cell Respiration by Nitric Oxide" Cancer Res.56. 4535-4540 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Minamiyama: "Albumin is an important vascular tonus regulator as a reservoir of nitric oxide" Biochem. Biophys. Res. Commun.225. 112-11 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Kashiba: "Role of ascorbic acid in the metabolism of S-nitrosoglutathione" FEBS Lett.389. 149-152 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Fujino: "DNA fragmentation of oocytes in aged mice" Human Reproduction. 11. 1480-1483 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Inai: "Oxygen-dependent regulation of Ehrlich ascites tumor cell respiration by NO" Cell Struct. Funct.21. 151-157 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S. Kashiwagi: "Characterization of two distinct potassium channels and gap junctional communication in cultured rat hepatic stellate cells" Am. J. Physiol.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Minamiyama: "Dynamic Aspects of glutathione and nitric oxide metabolism in endotoxemic rats" Am. J. Physiol.34. G575-581 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Takehara: "Molecular Mechanism for NO-dependent regulation of mitochondrial energy transduction" Free Radical Biol. & Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Takehara: "Proposed mechanism for the reversible inhibition of mitochondrial respiration by nitric oxide" Cell Strnct. Funct.21. 251-258 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H. Hanada: "Does reactive oxygen underlie the mechanism for the apoptotic disappearance of tadpole tail" Free Radical Biol. & Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Yabuki: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad. Res. Commun.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S. Iha: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide" Free Radical Res. Commun.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Kawada: "Effect of endothelins on hepatic stellate cells" Hepatology. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Yabuki: "Enhanced DNA fragmentation in HL-60 cells by nitric oxide under low oxygen tension" Free Rad. Res.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S. Okada: "Nitric oxide, a physiological modulator of mitochondrial function" Physiol. Chem. Physics. 28. 69-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I. Matsuoka: "Impact of erythrocytes on mouse embryonal" FEBS Lett.371. 297-299 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Fujino: "DNA fragmentation of oocytes in aged mice" Human Reproduction. 11. 1480-1483 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Kawada: "Expession of heat shock protein 47 in mouse liver" Cell Tissue Res.284. 341-346 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Kawada: "Inhibition of myofibroblastic transformation of rat hepatic stellete cells by methylxanthine and cAMP" Dig. Dis. Sci.41. 1022-1029 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Kawada: "Pathophysiology of acute obstructive cholangitis" J. hep. Bil. Pancr. Surg.3. 4-8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Sawamoto: "Pharmacokinetics of acetaminophen sulfate after oral administration in rats : analysis of plasma profiles exhibiting non-linear second peak" Biol. Pharm. Bull.19 (1). 77-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K. Iwata: "Disposition of intravenously administered adenosine 5′-phosphosulfate (APS) in rats" Biol. Pharm. Bull.19 (3). 438-443 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Kimura: "Oral administration of insulin as poly (vinyl alcohol) -gel spheres in diabetic rats" Biol. Pharm. Bull.19 (6). 897-900 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Z. Wang: "Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease" Biol. Pharm. Bull.19 (6). 901-904 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A. Tsuji: "Peptide Based Drug Design : Controlling Transport and Metabolism" American Chemical Society, 34 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T. Terasaki: "Peptide-based drug design : Controlling Transport and Metabolism" American Chemical Society, 20 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 乾 賢一: "腎臓学-病態生理からのアプローチ" 南江堂, 442 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Brain Physiology and Disorder" Academic Press, 8 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Biology of nitric oxide" Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Minamiyama: "Biology of nitric oxide" Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S. Takemura: "Biology of nitric oxide" Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Food and Free Radicals" Plenum Press (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Meth. Enzymol. Vol. 269" Academic Press, 6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Meth. Enzymol. Vol. 268" Academic Press, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Kawada: "Cells of the Hepatic Sinusoid Vol. 6" (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M. Inoue: "Cells of the Hepatic Sinusoid Vol. 6" (in press), (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上正康: "活性酸素と医食同源" 共立出版, 356 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上正康: "活性酸素とシグナル伝達" 講談社, 220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上正康: "アポトーシスの分子機構と病態" メディカルトリビューン社, 126 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y. Sugiyama: "Advanced Biomaterials in Biomedical Engineering and Drug Delivery" Springer-Verlag, 6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N. Okudaira: "Model Systems Used for Biopharmaceutical Assessment of Drug" 28 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉山雄一: "薬理学(上)" 廣川書店, 47 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 楠原洋之: "P糖蛋白質の生理機能" 中外医学社, 7 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] G. Tsujimoto: "Receptor desensitization and Ca2+- signaling : Cellular aspects of" Japan Scientific Societies Press, 22 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 辻本豪三: "薬の正しい使い方(日本医師会生涯教育シリーズ)" 医学書院, 3 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上昌次郎: "睡眠のメカニズム" 朝倉書店, (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ohnishi: "In vivo and in vitro evidence for ATP-dependency of P-glycoproteinmediated efflux of doxorubicin at the blood-brain barrier" Biochem.Pharmacol.49. 1541-1544 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Na^+ and Cl^- -dependent transport of taurine at the blood-brain barrier" Biochem.Pharmacol.50. 1783-1793 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Takanaga: "cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter" Biochem.Biophys.Res.Commun.217. 370-377 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Terasaki: "Hepatic uptake of octeotide, a long-acting somatostatin analogue, via a bile acid transport system" Pharm.Res.12. 12-17 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Functional expression of transporter for beta-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines" J.Pharmacol.Exp.Ther.273. 26-31 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Minagawa: "Species differences in hydrolysis of isocarbacyclin methyl ester (TEI9090) by blood esterases" Biochem.Pharmacol.49. 1361-1366 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids" Biochem.Biophys.Res.Commun.214. 482-489 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Proton-cotransport of pravastatin across intestinal brush-border membrane" Pharm.Res.12. 1727-1732 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Matsumoto: "Transport characteristics of ceftibuten, a new cephalosporin antibiotic, via the apical H^+/dipeptide cotransport system in the human intestinal cell line Caco-2 : Regulation by cell growth." Pharm.Res.12(10). 1483-1487 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Hirai: "Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein" J.Pharmacol.Exp.Ther.275(1). 73-78 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Tomita: "Transport of oral cephalosporins by the H^+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells" J.Pharmacol.Exp.Ther.272(1). 63-69 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Nagai: "Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line" J.Pharmacol.Exp.Ther.274(3). 1161-1166 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito: "Cloning and characterization of a rat H^+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney" J.Pharmacol.Exp.Ther.275(3). 1631-1637 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Iwata: "High-performance liquid chromatographic determination of diadenosine 5', 5'''-p1, p4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in" J.Chromatogr.B.667(2). 339-343 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Iwata: "Ca^<2+> Dependency of diadenosine 5', 5'''-p1, p4-tetraphosphate degradation in dog plasma" Biol.Pharm.Bull.18(5). 788-790 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nakagawa: "Biopharmaceutical studies on drug/conjugated-metabolite interactions. I.Fate of acetaminophen sulfate, a major conjugated metabolite of acetaminophen, in rats" Int.J.Pharm.121(1). 55-63 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Z.Wang: "Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract" Biol.Pharm.Bull.18(9). 1238-1241 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Disposition of diadenosin 5', 5'''-p1, p4-tetraphosphate (Ap4A) in rats" Biol.Pharm.Bull.18(11). 1556-1559 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Nishikawa: "Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties" Am.J.Physiol.268(5). G849-G856 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Nishikawa: "Design for cell-specific targeting of proteins utilizing sugarrecognition mechanism : effect of molecular weight of proteins on targeting efficiency" Pharm.Res.12(2). 209-214 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Hashida: "Hepatic targeting of drugs and proteins by chemical modification" J.Controlled Release. 36(1-2). 99-107 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells" J.Pharmacol.Exp.Ther.272(2). 739-743 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Binding affinity of N^3-substituted uridine for synaptic membrane and their CNS depressant effects" Nucleic Acids Symposium Series. 34. 147-148 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Haba: "Uptake mechanism of fractionated ^3H-heparin by isolated rat kupffer cells" Xenobio.Metabol.Dispos.10(supple). s104-107 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells" J.Pharmcol.Exp.Ther.272. 739-743 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Takehara: "Oxygen dependent regulation of mitochondrial functions by nitric oxide" Arch.Biochem.Biophys.323(1). 27-32 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Matsuoka: "Impact of erythrocytes on mouse embryonal development in vitro" FEBS Lett.371. 297-299 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Z.Radak: "Superoxide dismutase derivative prevents the exhaustive exercise induced oxidative damage in liver and kidney of rats" J.Applied Physiol.79. 129-135 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Kawamoto: "Changes in the circulatory status and transport functions of the liver induced by reactive oxygen species" Am.J.Physiol.268. G47-G53 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Nishimura: "Inhibition of puromycin-induced renal injury by a superoxide dismutase with prolonged half-life in the circulation" Nephron. 70. 460-465 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Ono: "A negative chronotropic effect of endothelin-1 mediated through ETA receptor in guinea pig atria" Circ.Res.76. 284-292 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kuwabara: "Receptor-mediated clearnance of G-CSF derivative nartograstim in bone marrow of rats" Am.J.Physiol.269. E1-E9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kuwabara: "Saturable uptake of a recombinant human granulocyte colony stimulating factor derivative nartograstim by the bone marrow and spleen of rats in vivo" J.Pharmacol.Exp.Ther.273. 1114-1122 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Takikawa: "Binding of lithocholate and its glucuronide and sulfate by human serum albumin" Biochem.Biophys.Acta. 1244. 277-282 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ke-Xin.Liu: "Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats" Am.J.Physiol.269. G1-G9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.Hirasawa: "Cloning, functional expression and tissue distribution of human alpha lc-adrenoceptor splice variants" FEBS Lett.363. 256-260 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.A.Esbenshade: "Cloning of the human alpha 1A/D-adrenergic receptor and inducible expression of three human subtypes in SKNMC cells" Mol.Pharmacol.47. 977-985 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Horie: "Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes" Brit.J.Pharmacol.116. 1611-1618 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Shibata: "KMD-3213, a novel, potent alpha 1a-adrenoceptor-selective antagonist : Characterization using recombinant human alpha 1-adrenoceptors and native tissues" Mol.Pharmacol.48. 250-258 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Utoguchi: "Effect of tumor cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen" Brit.J.Cancer. 73(1). 24-28 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Mizuguchi: "Glial conditioned medium elevates alkaline phosphatase activity in cultured bovine aortic endothelial cells" Microvasular Res.50. 129-132 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Tsutsumi: "Molecular design of hybrid tumor necrosis factor-alpha with polyethylene glycol increases its anti-tumor potency" Brit.J.Cancer. 71. 963-968 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Utoguchi: "Isolation and properties of tumor-derived endothelial cells from rat KMT-17 fibrosarcoma" Jpn.J.Cancer Res.86. 193-201 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Utoguchi: "Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayr" Cancer Lett.89. 7-14 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Central nervous system depressant effects of N^3-substituted derivatives of deoxyuridine in mice" Biol.Pharm.Bull.19(1). 142-145 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Watanabe: "Uptake of fractionated ^3H-heparin by isolated rat Kupffer cells" Pharm.Res.12. 1092-1095 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Watanabe: "Uptake of low molecular weight fractionated [^3H] heparin by rat hepatocytes in the primary culture" Biol.Pharm.Bull.18. 443-446 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Sai: "Immunolocarization and pharmacological relevance of oligopeptide transporter Pep T1 in intestinal absorption of beta-lactam antibiotics" FEBS Lett.392(1). 25-29 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Komura: "Na^+ and Cl^- dependent transport of beta-alanine across the blood-brain barrier" J.Neurochem.67(1). 330-305 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Miyamoto: "Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter" Biochim.Biophys.Acta. 1305(1). 34-38 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.Tsuji: "Carrier-mediated intestinal transport of drugs" Pharm.Res.13 (7). 963-977 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Carrier-mediated approaches for oral drug delivery" Adv.Drug Delivery Rev. 20. 5-32 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Tamai: "Drug delivery through the blood-brain barrier" Adv.Drug Delivery Rev. 19. 401-424 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ogihara: "Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells" Pharm.Res.13(12). 1828-1832 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Terao: "Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as as absorption barrier" J.Pharm.Pharmacol.48. 1083-1089 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Minagawa: "Blood-brain-barrier transport of lipid microspheres containing clinoprost, a prostaglandin I2 analogue" J.Pharm.Pharmacol.48. 1016-1022 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of EDTA,caprate, and decanyolcarnitine in Caco-2 cells" J.Pharm.Sci.85(6). 608-611 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ohtomo: "Transport of levofloxacin in a kidney epithelial cell line, LLC-PK1 : Interaction with organic cation transporters in apical and basolateral membranes" J.Pharmacol.Exp.Ther.276(3). 1143-1148 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Ogihara: "Immuno-localization of H^+/peptide cotransporter in rat digestive tract" Biochem.Biophys.Res.Commun.220(3). 848-852 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito: "Molecular cloning and tissue distribution of rat peptide transporter PEPT2" Biochim.Biophys. Acta. 1280(2). 173-177 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Tanaka: "Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein" Pharm.Res.13(7). 1073-1077 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nabekura: "Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes" Pharm.Res.13(7). 1069-1072 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Okuda: "cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2" Biochem.Biophys.Res.Commun.224(2). 500-507 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito: "Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney" J.Biol.Chem.271(34). 20719-20725 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Takano: "Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells" Am.J.Physiol.271(2). F469-475 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Nabekura: "Cholesterol modulates organic cation transport activity and lipid fluidity in rat renal brush-border membranes" Biochim.Biophys.Acta. 1283(2). 232-236 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Terada: "Identification of the histidine residues involved in substrate recognition by a rat H^+/peptide cotransporter, PEPT1" FEBS Lett.394(2). 196-200 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Saito: "Na^+-Dependent uptake of 1,5-anhydro-D-glucitol via the transport systems for D-glucose and D-mannose in kidney epithelial cell line, LLC-PK1" Jpn.J.Nephrol.38(10). 435-440 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Nishikawa: "Oxygen-Dependent Regulation of Ascites Tumor Cell Respiration by Nitric Oxide" Cancer Res.56. 4535-4540 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Minamiyama: "Albumin is an important vascular tonvs regulator as a reservoir of nitric oxide" Biochem.Biophys.Res.Commun.225. 112-115 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Kashiba: "Role of ascorbic acid in the metabolism of S-nitrosoglutathione" FEBS Lett.389. 149-152 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Fujino: "DNA fragmentation of oocytes in aged mice" Human Reproduction.11. 1480-1483 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Inai: "Oxygen-dependent regulation of Ehrlich ascites tumor cell respiration by NO" Cell Struct.Funct.21. 151-157 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Kashiwagi: "Characterization of two distinct potassium channels and gap junctional communication in cultured rat hepatic stellate cells" Am.J.Physiol.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Minamiyama: "Dynamic Aspects of glutathione and nitric oxide metabolism in endotoxemic rats" Am.J.Physiol.34. G575-581 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Takehara: "Molecular Mechanism for NO-dependent regulation of mitochondrial energy transduction" Free Radical Biol.& Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Takehara: "Proposed mechanism for the reversible inhibition of mitochondrial respiration by nitric oxide" Cell Strnct.Funct. 21. 251-258 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hanada: "Does reactive oxygen underlie the mechanism for the apoptotic disappearance of tadpole tail" Free Radical Biol.& Medicine. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Yabuki: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad.Res.Commun.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Iha: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide" Free Radical Res.Commun.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kawada: "Effect of endothelins on hepatic stellate cells" Hepatology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Yabuki: "Enhanced DNA fragmentation in HL-60 cells by nitric oxide under low oxygen tension" Free Rad.Res.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Okada: "Nitric oxide, a physiological modulator of mitochondrial function" Physiol.Chem.Physics. 28. 69-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] I.Matsuoka: "Impact of erythrocytes on mouse embryonal" FEBS Lett.371. 297-299 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Fujino: "DNA fragmentation of oocytes in aged mice" Human Reproduction. 11. 1480-1483 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kawada: "Expression of heat shock protein 47 in mouse liver" Cell Tissue Res.284. 341-346 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kawada: "Inhibition of myofibroblastic transformation of rat hepatic stellete cells by methylxanthine and cAMP" Dig.Dis Sci. 41. 1022-1029 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kawada: "Pathophysiology of acute obstructive cholangitis" J.hep.Bil.Pancr.Surg.3. 4-8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sawamoto: "Pharmacokinetics of acetaminophen sulfate after oral administration in rats : analysis of plasma profiles exhibiting non-linear second peak" Biol.Pharm.Bull.19(1). 77-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Iwata: "Disposition of intravenously administered adenosine 5'-phosphosulfate (APS) in rats" Biol.Pharm.Bull.19(3). 438-443 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Oral administration of insulin as poly (vinyl alcohol) -gel spheres in diabetic rats" Biol.Pharm.Bull.19(6). 897-900 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Z.Wang: "Pharmacokinetics of glycyrrhizin in rats with D-galactosamineinduced hepatic disease" Biol.Pharm.Bull.19(6). 901-904 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] D.Nakai: "Cellular uptake mechanism for oligonucleotides : Involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15" J.Pharmacol.Exp.Ther.278. 1362-1372 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] D.Nakai: "Evaluation of the efficiency of targeting of antitumor drugs : Simulation analysis based on pharmacokinetic/pharmacodynamic considerations" J.Drug Target. 3. 443-453 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Takikawa: "Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats" Hepatology. 23. 1642-1649 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ooie: "Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus" Pharm.Res.13. 523-527 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.Kakee: "Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier" J.Pharmacol.Exp.Ther.277. 1550-1559 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] A.Tsuji: Peptide Based Drug Design : Controlling Transport and Metabolism. American Chemical Society, 34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Terasaki: Peptide-based drug design : Controlling Transport and Metabolism. American Chemical Society, 20 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Brain Physiology and Disorder. Academic Press, 8 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Biology of nitric oxide. Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Minamiyama: Biology of nitric oxide. Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Takemura: Biology of nitric oxide. Portland Press (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Food and Free Radicals. Plenum Press (in Press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Meth.Enzymol.Vol.269. Academic Press, 6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Meth.Enzymol.Vol.268. Academic Press, 7 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Kawada: Cells of the Hepatic Sinusoid Vol.6. (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Inoue: Cells of the Hepatic Sinusoid Vol.6. (in press), (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Sugiyama: Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems.Springer-Verlag, 6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Okudaira: Model Systems Used for Biopharmaceutical Assessment of Drug Absorption and Metabolism Vol.12. 28 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] G.Tsujimoto: Receptor desensitization and Ca2+- signaling : Cellular aspects of possible molecular dynamics. Japan Scientific Societies press, 22 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ohnishi: "In vivo and vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier" Biochem. Pharmacol.49. 1541-1544 (1995)

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      1996 Annual Research Report
  • [Publications] I.Tamai: "Na^+ and Cl^- -dependent transport of taurine at the blood-brain barrier" Biochem. Pharmacol.50. 1783-1793 (1995)

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      1996 Annual Research Report
  • [Publications] H.Takanaga: "cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter" Biochem. Biophys. Res.Commun.217. 370-377 (1995)

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      1996 Annual Research Report
  • [Publications] T.Terasaki: "Hepatic uptake of octeotide,a long-acting somatostatin analogue,via a bile acid transport system" Pharm. Res.12. 12-17 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Tamai: "Functional expression of transporter for β-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human,rat and rabbit small intestines" J.Pharmacol. Exp.Ther.273. 26-31 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Minagawa: "Species differences in hydrolysis of isocarbacyclin methyl ester (TEI9090) by blood esterases" Biochem. Pharmacol.49. 1361-1366 (1995)

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      1996 Annual Research Report
  • [Publications] I.Tamai: "Participation of a proton-cotransporter,MCTI,in the intestinal transport of monocarboxylic acids" Biochem. Biophys. Res.Commun.214. 482-489 (1995)

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      1996 Annual Research Report
  • [Publications] I.Tamai: "Proton-cotransport of pravastatin across intestinal brush-border membrane" Pharm. Res.12. 1727-1732 (1995)

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      1996 Annual Research Report
  • [Publications] 玉井郁巳: "ジペプチドトランスポーターと医薬品の消化管吸収" ファルマシア. 31. 493-497 (1995)

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      1996 Annual Research Report
  • [Publications] 辻 彰: "薬物相互作用-P糖蛋白質" ファルマシア. 31. 997-1001 (1995)

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      1996 Annual Research Report
  • [Publications] S.Matsumoto: "Transport characteristics of ceftibuten,a new cephalosporin antibiotic,via the apical H^+/dipeptide cotransport system in the human intestinal cell line C_<aco>-2 : Regulation by cell growth." Pharm. Res.12(10). 1483-1487 (1995)

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      1996 Annual Research Report
  • [Publications] M.Hirai: "Cepharanthin,a multidrug resistant modifier,is a substrate for P-glycoprotein" J.Pharmacol. Exp.Ther.275(1). 73-78 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Tomita: "Transport of oral cephalosporins by the H^+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells" J.Pharmacol. Exp.Ther.272(1). 63-69 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Nagai: "Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line" J.Pharmacol. Exp.Ther.274(3). 1161-1166 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Saito: "Cloning and characterization of a rat H^+/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney" J.Pharmacol. Exp.Ther.275(3). 1631-1637 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Iwata: "High-performance liquid chromatographic determination of diadenosine 5^|,5^<|||>-p1,p4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in whole blood" J.Chromatogr. B.667(2). 339-343 (1995)

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      1996 Annual Research Report
  • [Publications] K.Iwata: "Ca^<2+> Dependency of diadenosine 5^|,5^<|||>-p1,p4-tetraphosphate degradation in dog plasma" Biol. Pharm. Bull.18(5). 788-790 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Nakagawa: "Biopharmaceutical studies on drug/conjugated-metabolite interactions. I.Fate of acetaminophen sulfate,a major conjugated metabolite of acetaminophen,in rats" Int.J.Pharm.121(1). 55-63 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Z.Wang: "Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract" Biol. Pharm. Bull.18(9). 1238-1241 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "Disposition of diadenosine 5^|,5^<|||>-P1,P4-tetraphosphate (Ap4A) in rats" Biol. Pharm. Bull.18(11). 1556-1559 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "プロドラッグによるAzidothymidineの脳移行性改善" DDS. 10(6). 413-417 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Nishikawa: "Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties" Am.J.Physiol.268(5). G849-G856 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Nishikawa: "Desigh for cell-specific targeting of proteins utilizing sugar-recognition mechanism : effect of molecular weight of proteins on targeting efficiency" Pharm. Res.12(2). 209-214 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Hashida: "Hepatic targeting of drugs and proteins by chemical modification" J.Controll. Release. 36(1-2). 99-107 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Motoya: "糖鎖認識機構を利用した細胞特異的薬物ターゲティング(Cell-specific targeting of drugs utilizing sugar-recognition systems)" Pharm. Tech. Japan. 11(4). 395-403 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells" J.Pharmacol. Exp.Ther.272(2). 739-743 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "Binding affinity of N^3-substituted uridine for synaptic membrane and their CNS depressant effects" Nucleic Acids Symposium Series. 34. 147-148 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Haba: "Uptake mechanism of fractionated ^3H-heparin by isolated rat kupffer cells" Xenobio. Metabol. Dispos.10(suppl. s104-107 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 掛江敦之: "血液脳関門-静的障壁からダイナミック・インターフェースへ-脳へのドラッグデリバリーの最近の進歩-その4-" Pharm. Tech. Japan. 11. 23-25 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine inCaco-2cells" J.Pharmcol. Exp. Ther.272. 739-743 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Takehara: "Oxygen dependent regulation of mitochondrial functions by nitric oxide" Arch. Biochem. Biophys.323(1). 27-32 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Matsuoka: "Impact of erythrocytes on mouse embryonal develoment in vitro" FEBS Lett.371. 297-299 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Z.Radak: "Superoxide dismutase derivative prevents the exhaustive exercise induced oxidative damage in liver and kidney of rats" J.Applied Physiol.79. 129-135 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Kawamoto: "Changes in the circulatory status and transport functions of the liver induced by reactive oxygen species." Am.J.Physiol.268. G47-G53 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Nishimura: "Inhibition of puromycin-inducedrenal injury by a superoxide dismutase with prolonged half-life in the circulation" Nephron. 70. 460-465 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Ono: "A negative chronotropic effect of endothelin-1 mediated through ETA receptor in guinea pig atria" Circ.Res.76. 284-292 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kuwabara: "Receptor-mediated clearnance of G-CSF derivative nartograstim in bone marrow of rats" Am.J.Physiol.269. E1-E9 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kuwabara: "Saturable uptake of a recombinant human granulocyte colony stimulating factor derivative nartograstim by the bone marrow and spleen of rats in vivo" J.Pharmacol. Exp.Ther.273. 1114-1122 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Takikawa: "Binding of lithocholate and its glucuronide and sulfate by human serum albumin" Biochem. Biophys. Acta. 1244. 277-282 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ke-Xin.Liu: "Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats" Am.J.Physiol.269. G1-G9 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] A.Hirasawa: "Cloning,functional expression and tissue distribution of human α 1c-adrenoceptor splice variants" FEBS Lett.363. 256-260 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.A.Esbenshade: "Cloning of the human α 1A/D-adrenergic receptor and inducible expression of three human subtypes in SKNMC cells" Mol.Pharmacol.47. 977-985 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Horie: "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α 1-adrenoceptor subtypes" Brit.J.Pharmacol.116. 1611-1618 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Shibata: "KMD-3213,a novel,potent α la-adrenoceptor-selective antagonist : Characterization using recombinant human α 1-adrenoceptors and native tissues" Mol.Pharmacol.48. 250-258 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Utoguchi: "Effect of tumor cell-conditioned medium on endothelial macromolecular permeability and its correlation with collagen" Brit.J.Cancer. 73(1). 24-28 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Mizuguchi: "Glial conditioned medium elevates alkaline phosphatase activity in cultured bovine aortic endothelial cells" Microvasular Res.50. 129-132 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Tsutsumi: "Molecular design of hybrid tumor necrosis factor-α with polyethylene glycol increases its anti-tumor potency" Brit.J.Cancer. 71. 963-968 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Utoguchi: "Isolation and properties of tumor-derived endothelial cells from rat KMT-17 fibrosarcoma" Jpn.J.Cancer Res.86. 193-201 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Utoguchi: "Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayer" Cancer Lett.89. 7-14 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "Central nervous system depressant effects of N^3-substituted derivatives of deoxyuridine in mice" Biol. Pharm. Bull.19(1). 142-145 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Kimura: "Localization of uridine receptor on synaptic membranes" Sleep Res.24A. 128 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Watanabe: "Uptake of fractionated ^3 H-heparin by isolated rat Kupffer cells" Pharm.Res.12. 1092-1095 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] J.Watanabe: "Uptake of low molecular weight fractionated 〔^3H〕 heparin by rat hepatocytes in the primary culture" Biol. Pharm. Bull.18. 443-446 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Sai: "Immunolocarization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β-lactam antibiotics" FEBS Lett.392(1). 25-29 (1996)

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      1996 Annual Research Report
  • [Publications] J.Komura: "Na^+ and Cl^- dependent transport of β-alanine across the blood-brain barrier" J.Neurochem.67(1). 330-305 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Miyamoto: "Sequence,tissue distribution and developmental changes in rat intestinal oligopeptide transporter" Biochim. Biophys. Acta. 1305(1). 34-38 (1996)

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      1996 Annual Research Report
  • [Publications] A.Tsuji: "Carrier-mediated intestinal transport of drugs" Pharm.Res.13(7). 963-977 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Tamai: "Carrier-mediated approaches for oral drug delivery" Adv.Drug Delivery Rev.20. 5-32 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Tamai: "Drug delivery through the blood-brain barrier" Adv.Drug Delivery Rev.19. 401-424 (1996)

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      1996 Annual Research Report
  • [Publications] T.Ogihara: "Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells" Pharm.Res.13(12). 1828-1832 (1996)

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      1996 Annual Research Report
  • [Publications] T.Terao: "Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as as absorption barrier" J.Pharm. Pharmacol.48. 1083-1089 (1996)

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      1996 Annual Research Report
  • [Publications] T.Minagawa: "Blood-brain-barrier transport of lipid microspheres containing clinoprost,a prostaglandin I2 analogue" J.Pharm. Pharmacol.48. 1016-1022 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Tomita: "Absorption-enhancing mechanism of EDTA,caprate,and decanyolcarnitine in Caco-2 cells" J.Pharm. Sci.85(6). 608-611 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Ohtomo: "Transport of levofloxacin in a kidney epithelial cell line,LLC-PK 1: Interaction with organic cation transporters in apical and basolateral membranes" J.Pharmacol. Exp.Ther.276(3). 1143-1148 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Ogihara: "Immuno-localization of N^+/peptide cotransporter in rat digestive tract" Biochem. Biophys. Res.Commun.220(3). 848-852 (1996)

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      1996 Annual Research Report
  • [Publications] H.Saito: "Molecular cloning and tissue distribution of rat peptide transporter PEPT2" Biochim. Biophys. Acta. 1280(2). 173-177 (1996)

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      1996 Annual Research Report
  • [Publications] K.Tanaka: "Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein" Pharm.Res.13(7). 1073-1077 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Nabekura: "Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes" Pharm.Res.13(7). 1069-1072 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Okuda: "cDNA cloning and functional expression of a novel rat kidney organic cation transporter,OCT2" Biochem. Biophys. Res.Commun.224(2). 500-507 (1996)

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      1996 Annual Research Report
  • [Publications] H.Saito: "Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney" J.Biol.Chem.271(34). 20719-20725 (1996)

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      1996 Annual Research Report
  • [Publications] M.Takano: "Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells" Am.J.Physiol.271(2). F469-F475 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Nabekura: "Cholesterol modulates organic cation transport activity and lipid fluidity in rat renal brush-border membranes" Biochim. Biophys. Acta. 1283(2). 232-236 (1996)

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      1996 Annual Research Report
  • [Publications] T.Terada: "Identification of the histidine residues involved in substrate recognition by rat H^+/peptide cotransporter. PEPT1" FEBS Lett.394(2). 196-200 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Saito: "Na^+-Dependent uptake of 1,5-anhydro-D-glucitol via the transport systems for D-glucose and D-mannose in kidnev epithelial cell line. LLC-PK1" Jpn.J.Nephrology.38(10). 435-440 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Nishikawa: "Oxygen-Dependent Regulation of Ascites Tumor Cell Respiration by Nitric Oxide" Cancer Res.56. 4535-4540 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Minamiyama: "Albumin is an important vascular tonus regulator as a reservoir of nitric oxide" Biochem. Biophys. Res.Commun.225. 112-11 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Kashiba: "Role of ascorbic acid in the metabolism of S-nitrosoglutathione" FEBS Lett.389. 149-152 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Fujino: "DNA fragmentation of oocytes in aged mice." Human Reproduction. 11. 1480-1483 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Inai: "Oxygen-dependent regulation of Ehrlich ascites tumor cell respiration by NO" Cell Struct. Funct.21. 151-157 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Kashiwagi: "Characterization of two distinct potassium channels and gap junctional communication in cultured rat hepatic stellate cells" Am.J.Physiol.(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Minamiyama: "Dynamic Aspects of glutathione and nitric oxide metabolism in endotoxemic rats" Am.J.Physiol.34. G575-581 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Takehara: "Molecular Mechanism for NO-dependent regulation of mitochondrial energy transduction" Free Radical Biol.& Medicine. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Takehara: "Proposed mechanism for the reversible inhibition of mitochondrial respiration by nitric oxide" Cell Strnct. Funct. 21. 251-258 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Hanada: "Does reactive oxygen underlie the mechanism for the apoptotic disappearance of tadpole tail" Free Radical Boil.& Medicine. (in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Yabuki: "Oxygen-dependent fragmentation of cellular DNA by nitric oxide" Free Rad.Res.Commun.(in press). (1996)

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      1996 Annual Research Report
  • [Publications] S.Iha: "Oxygen-dependent inhibition of neutrophil respiratory burst by nitric oxide" Free Radical Res.Commun.(in press). (1996)

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      1996 Annual Research Report
  • [Publications] N.Kawada: "Effect of endothelins on hepatic stellate cells" Hepatology. (in press). (1996)

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      1996 Annual Research Report
  • [Publications] M.Yabuki: "Enhanced DNA fragmentation in HL-60 cells by nitric oxide under low oxygen tension" Free Rad.Res.(in press). (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Okada: "Nitric oxide,a physiological modulator of mitochondrial function" Physiol.Chem.Physics. 28. 69-82 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] I.Matsuoka: "Impact of erythrocytes on mouse embryonal" FEBS Lett.371. 297-299 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Fujino: "DNA fragmentation of oocytes in aged mice" Human Reproduction. 11. 1480-1483 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Kawada: "Expression of heat shock protein 47 in mouse liver" Cell Tissue Res.284. 341-346 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Kawada: "Inhibition of myofibroblastic transformation of rat hepatic stellete cells by methylxanthine and cAMP" Dig.Dis.Sci.41. 1022-1029 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Kawada: "Pathophysiology of acute obstructive cholangitis" J.hep.Bil.pancr.Surg.3. 4-8 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Sawamoto: "Pharmacokinetics of acetaminophen sulfate after oral administration in rats : analysis of plasma profiles exhibiting non-linear second peak" Biol.Pharm.Bull.19(1). 77-82 (1996)

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      1996 Annual Research Report
  • [Publications] K.Iwata: "Disposition of intravenously administered adenosine 5^|-phosphosulfate (APS) in rats" Biol. Pharm. Bull.19(3). 438-443 (1996)

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      1996 Annual Research Report
  • [Publications] T.Kimura: "Oral administration of insulin as poly (vinyl alcohol)-gel spheres in diabetic rats" Biol. Pharm. Bull.19(6). 897-900 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Z.Wang: "Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease" Biol. Pharm. Bull.19(6). 901-904 (1996)

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      1996 Annual Research Report
  • [Publications] A.Tsuji: "Peptide Based Drug Design : Controlling Transport and Metabolism" American Chemical Society, 34 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Terasaki: "Peptide-based drug design : Controlling Transport and Metabolism" American Chemical Society, 20 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 乾 賢一: "腎臓学-病態生理からのアプローチ" 南江堂, 442 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Inoue: "Brain Physiology and Disorder" Academic Press, 8 (1996)

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      1996 Annual Research Report
  • [Publications] M.Inoue: "Biology of nitric oxide" Portland Press (in press), (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Minamiyama: "Biology of nitric oxide" Portland Press (in press), (1996)

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      1996 Annual Research Report
  • [Publications] S.Takemura: "Biology of nitric oxide" Portland Press (in press), (1996)

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      1996 Annual Research Report
  • [Publications] M.Inoue: "Food and Free Radicals" Plenum Press (in press), (1996)

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      1996 Annual Research Report
  • [Publications] M.Inoue: "Meth.Enzymol.Vol.269" Academic Press, 6 (1996)

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      1996 Annual Research Report
  • [Publications] M.Inoue: "Meth.Enzymol.Vol.268" Academic Press, 7 (1996)

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      1996 Annual Research Report
  • [Publications] N.Kawada: "Cells of the Hepatic Sinusoid Vol.6" (in press), (1996)

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      1996 Annual Research Report
  • [Publications] M.Inoue: "Cells of the Hepatic Sinusoid Vol.6" (in press), (1996)

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      1996 Annual Research Report
  • [Publications] 井上正康: "活性酸素と医食同源" 共立出版, 356 (1996)

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      1996 Annual Research Report
  • [Publications] 井上正康: "活性酸素とシグナル伝達" 講談社, 220 (1996)

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      1996 Annual Research Report
  • [Publications] 井上正康: "アポトーシスの分子機構と病態" メディカルトリビューン社, 126 (1996)

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      1996 Annual Research Report
  • [Publications] Y.Sugiyama: "Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems." Springer-Verlag, 6 (1996)

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      1996 Annual Research Report
  • [Publications] N.Okudaira: "Model Systems Used for Biopharmaceutical Assessment of Drug Absorption and Metabolism Vol.12" 28 (1996)

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      1996 Annual Research Report
  • [Publications] 杉山雄一: "薬理学(上)" 廣川書店, 47 (1996)

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      1996 Annual Research Report
  • [Publications] 楠原洋之: "P糖蛋白質の生理機能" 中外医学社, 7 (1996)

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      1996 Annual Research Report
  • [Publications] G.Tsujimoto: "Receptor desensitization and Ca^<2+>-signaling : Cellular aspects of possible molecular dynamics" Japan Scientific Societies Press, 22 (1996)

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      1996 Annual Research Report
  • [Publications] 辻本豪三: "薬の正しい使い方(日本医師会生涯教育シリーズ)" 医学書院, 3 (1996)

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      1996 Annual Research Report
  • [Publications] 井上昌次郎: "睡眠のメカニズム" 朝倉書店, (1997)

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      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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