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EVALUATION OF THE MUTAGENICITY IN THE ENVIRONMENTAL WATER

Research Project

Project/Area Number 07308041
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section総合
Research Field Environmental dynamic analysis
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

HAYATSU Hikoya  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (10012593)

Co-Investigator(Kenkyū-buntansha) HORIKAWA Kazumi  FUKUOKA HEALTH AND ENVIRONMENTAL RESEARCH CENTER,RESEARCHER, 保健科学部, 専門研究員
NOGAMI Yusaku  OKAYAMA UNIVERSITY OF SCIENCES,FACULTY OF SCIENCES,PROFESSOR, 理学部, 教授 (00172768)
NAKAMURO Katsuhiko  SETSUNAN UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (30172464)
KIRA Shohei  OKAYAMA UNIVERSITY,FACULTY OF MEDICAL SCIENCES,LECTURER, 医学部, 講師 (50033212)
UTSUMI Hideo  KYUSHU UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (20101694)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1996: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1995: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsADSORBENT FOR MUTAGEN / BLUE CHITIN COLUMN / CARCINOGENS IN ENVIRONMENTAL WATER / BIOLOGICAL MONITORING / ENVIRONMENTAL POLLUTION / 健康影響 / 生物学的環境モニタリング / 環境汚染 / ブルーレイヨンカラム濃縮法
Research Abstract

Using the blue chitin column technique, mutagens in the water of two rivers (Katsura river in Kyoto, and Asahi river in Okayama), were monitored. The results were compared with these found by already available method, the XAD-2 resin concentration technique. As a result, the blue chitin method proved to be 2 times more efficient in concentrating the mutagens. The blue rayon hanging technique was used to monitor mutagens in lakes in the Fukuoka area and the results showed that the lakes that showed no high COD values gave positive mutagenic responses. In conclusion, the blue chitin column and blue rayon hanging methods have been firmly established as techniques for monitoring mutagens in the environmental waters.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 早津彦哉: "A short-column technique for concentrating mutagens/carcinogens having polycyclic structures" Analytical Biochemistry. 235. 185-190 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 内海英雄: "Application of micronucleus in vitro assay to micropollutants in river water" Water Science and Technology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 堀川和美: "Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test" J.Toxicological & Environmental Chemistry. 54. 161-165 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 阪本博: "Evaluation of blue-chitin columm,blue-rayon hanging,and XAD-resin column techniques for concentrating mutagens from two Japanese rivers" Mutation Res.371. 79-85 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 吉良尚平、野上祐作、早津彦哉: "A simple technique for monitaring mutagenicity and benzo (a) pyrene content in mussels and their ambient water" Environ.Toxicol.Water Qual.10. 167-172 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 中室克彦: "Disinfection by-products in the chlorination of organic nitrogen compounds : By-products from kynurenine" Chemoshere. 33. 1425-1433 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Kira, Taketa, T.Nogami, H.Hayatsu: "A simple technique for monitaring mutagenicity and benzo (a) pyrene content in mussels and their ambient water." Environ.Toxicol.Water Qual.10. 167-172 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hayatsu, T.Hayatsu, S.Arimoto and H.Sakamoto: "A short-column technique for concentrating mutagens/carcinogens having polycyclic structures." Analytical Biochemistry. 235. 185-190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Kira, Y.Nogami, K.Taketa, and H.Hayatsu: "Comparison of techniques for monitoring water-borne polycyclic mutagens : efficiency of blue rayon, Sep-Pak C18, and a biota, Corbicula, in concentrating benzo (a) pyrene in a model water system." Bull.Environ.Contam.Toxicol.57. 278-283 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hayatsu, H.Sakamoto, S.Kira and Y.Nogami: "Monitoring of water-borne polycyclic mutagens." PAEMS Proceedings Supplement of the African Newsletter on Occupational Health and Safety. 6. 14-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hayatsu, T.Kubo, Y.Tanaka and K.Negishi: "Polynucleotide-Chitosan Complex : Preparation, properties and applications." Nucleic Acid Symposium Series. 35. 253-254 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Mure, H.Hayatsu, T,Takeuchi T.Takeshita and K.Morimoto: "Heavy cigarette smokers show higher mutagenicity in urine." Mutation Res.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Sakamoto, T.Ohe, T.Hayatsu and H.Hayatsu: "Evaluation of blue-chitin column, blue-rayon hanging, and XAD-resin column techniques for concentrating mutagens from two Japanese reivers." Mutation Res.371. 79-85 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hayatsu, Y.Tanaka and T.Hayatsu: "Non-covalent binding of carcinogenic heterocyclic amines to polynucleotides." Collet.Czech.Chem.Commun.Special Issue. 61. 250-252 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Kira, Y.Nogami, T.Ito and H.Hayatsu: "Detection of benzo (a) pyrene and mutagenicity in water of Lake Baikal (Russia) and of rivers in Okayama (Japan) using the blue rayon method : a simplified handling and transportation of samples from remote sites." Environ.Toxicol.Water Qual.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Ueno, T.Moto, Y.Sayato, K.Nakamuro: "Disinfection by-products in the chlorination of organic nitrogen compounds : By-products from kynurenine." Chemoshere. 33. 1425-1433 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Murakami, N.Sera and K.Horikawa: "Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test." The Journal of Toxicological and Environmental Chemistry. 54. 161-165 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Horikawa, N.Sera, K.Murakami, N.Sano, K.Izumi and H.Tokiwa: "Mutagenicity and tumorigenicity of 1- and 3- nitrobenzo (a) pyrene and 3,6- and 1,6-dinitrobenzo (a) pyrene and related compounds." Carcinogenesis. (in press). (1977)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.-S.Chung, K.Ichikawa and H.Utsumi: "Application of micronucleus in vitro assay to micropollutants in river water." Water Sciences and Technology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Hayatsu: Complex formation of heterocyclic amines with porphyrins ; its use in detection and prevention. Heterocyclic Amines in Cooked Food : Possible Human Carcinogens, eds.by R.H.Adamson, J-A.Gustafsson, N.Ito, M.Nagao, T.Sugimura, K.Wakabayashi and Y.Yamazoe.Princeton Press, New Jersey, 172-180 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 早津彦哉: "A short-column technique for concetrating mutagens / carcinogens having polycyclic structures" Analytical Biochemistry. 235. 185-190 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 内海英雄: "Application of microleus in vitro assay to micropollutants in river water" Water Science and Technology. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 吉良尚平、野上祐作: "水環境中のベンツピレン(BaP)のTWA値の測定に関する一つの試み" 第31回日本水環境学会年会講演集. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 中室克彦: "揮発性塩素処理副生成物の変異原性及び給水栓水における分布" 水環境学会誌. 65・2. 20-27 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 堀川和美: "Evaluation of mutagenicity of complex mixture of mitroarenes using mouse micronuclei test" J.Toxicological & Environmental Chemistry. 54. 161-165 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 阪本 博: "Evaluation of blue-chitin column,blue-rayon hanging,and XAD-resin column techniques for concentrating mutagens from two Japanese rivers" Mutation Res.371. 79-85 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Kira,Y.Nogami,H.Hayatsu,et al.: "A simple technique for monitoring mutagenicity and benzo (a) 。-pyrene content in mussels and their ambient water." Environ.Toxicol.Water Qual.10. 167-172 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Murakami,K.Horikawa,et al.: "The induction of micronuclei in mice hepatocytes by tetrachloroethylene." Chemosphere. 31. 3733-3739 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] S.Kira,Y.Nogami,H.Hayatsu,et al.: "Comparison of technique for monitoring water-borne polycyclic mutagens ; Efficiency of blue rayon." Bull.Environ.Contam.Toxicol.(in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Hayatsu,et al.: "A short column technique for concentrating mutagen/carcinogens having polycyclic structures." Analytical Biochemistry. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Murakami,K.Horikawa,et al.: "Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test." The Journal of Toxicological and Environmental Chemistry. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] 中室 克彦 他: "アミノ酸の亜硝酸イオン共存下における塩素処理による変異原性の発現" 水環境学会誌. 18. 389-395 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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