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Inhibition of allergic and autoimmune responses by means of food proteins and peptides.

Research Project

Project/Area Number 07406006
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionThe University of Tokyo

Principal Investigator

KAMINOGAWA Shuichi  The University of Tokyo Grd.Sch.Agri.Life Sci. Professor, 大学院・農学生命科学研究科, 教授 (50011945)

Co-Investigator(Kenkyū-buntansha) TOTSUKA Mamoru  The University of Tokyo Grad.Sch.Agri.Life Sci. Assistant Professor, 大学院・農学生命科学研究科, 助手 (70227601)
HACHIMURA Satoshi  The University of Tokyo Grad.Sch.Agri.Life Sci. Assistant Professor, 大学院・農学生命科学研究科, 助手 (40238019)
AMERANI Akio  The University of Tokyo Grad.Sch.Agri.Life Sci. Associate Professor, 大学院・農学生命科学研究科, 助教授 (50201900)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1995: ¥20,000,000 (Direct Cost: ¥20,000,000)
KeywordsAllergy / Autoimmune disease / Oral tolerance / Altered peptide ligand / beta-Lactoglobulin / alpha_<s1>-Casein / Ovalbumin / Collagen / アナログペプチド / T細胞 / トランスジェニックマウス / 抗体産生 / サイトカイン産生 / α_<S1>-カゼイン / 免疫抑制 / 消化耐性 / II型コラーゲン / T細胞抗原決定基 / MHCクラスII分子
Research Abstract

Increase in the number of patients with allergies or autoimmune diseases have aroused the demand for developing safe and efficient means of treatment for these diseases. We aimed to develop such treatment by means of food proteins and peptides, and their amino-acid substituted analogs. 1.T-and B-cell responses to food allergens or a homologue of a self-antigen were analyzed in mice and in patients allergic to cow's milk. 2.Antigenic structure of beta-lactoglobulin, a major milk allergen, was analyzed in detail. Single amino-acid substituted analogs of beta-lactoglobulin or its partial peptide were examined for their inhibitory effect on allergen-specific immune responses, and shown to be effective. Moreover, we showed that single substituted analogs of a peptide from alpha_<s1>-casein, another major milk allergen, could modulate the CD8^+T-cell responses to the allergen. 3.The condition required for and the mechanism of induction of oral tolerance was investigated. We clarified the roles of CD4^+T cells, CD8^+T cells, and B cells, and the relationship between the dose of orally administered antigen and the induction of oral tolerance. Furthermore, the immune responses to orally administered antigens, including those of the gut-associated lymphoid tissue, were analyzed using T-cell receptor transgenic mice. 4.A novel means of inhibition of allergic or autoimmune responses was investigated. We showed that administration of protein or peptide antigens related to food allergens or self-antigens can efficiently inhibit antigen-specific immune responses in vivo. The use of anti-T-cell response was also shown to be effective in inhibiting autoimmune responses. We believe that the findings obtained in this study provide us with information useful not only for developing a novel way of treatment and prevention from allergies and autoimmune diseases but also for elucidating the mechanisms of oral tolerance, antigen recognition by immune system and onset of these diseases.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (67 results)

All Other

All Publications (67 results)

  • [Publications] K.Hirahara, et al.: "Profound Immunological tolerancein the antibody response against bovine α_<s1>-casein induced by intradermal administration of a dominant T celldeterminant." Clin.Immunol.Immunopathol.76. 12-18 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Hirahara, et al.: "CD4^+T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferredin SCID and nude mice." J.Immunol.154. 6238-6245 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, et al.: "α_<s1>-casein-specific CD8^+T cell clone that inhibits its own interferon-γ production by producing interleukin-10." Biosci.Biotech.Biochem.59. 2274-2274 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, et al.: "B cell activation by plasma membranes from activated helper T cells." Animal Cell Technology:Basic & Applied Aspects. 7. 509-514 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Kaminogawa.: "Food allergy, oral tolerance andimmunomodulation - their molecular and cellular mechanisms." Biosci.Biotech.Biochem.60. 1749-1756 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, et al.: "The direct cloning of the immunoglobulin V_H genes from primary cultured B cells specific for a short peptide." J.Biotechnol.49. 201-210 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Minai, et al.: "Difference in signal transduction for IL-10 and IFN-γ production in a CD8^+T cell clone." Cell.Immunol.172. 200-204 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Nakajima, et al.: "Establishment and characterisation of α_<s1>-casein-specific T-cell lines from patients allergic to cow'smilk:Unexpected higher frequency of CD8^+T cell lines." J.Allergy Clin.Immunol.97. 1342-1349 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ametani, et al.: "Consecutive events of growth,differentiation and death of the small intestinal epithelial cell line,IEC-6." In Vitro Cell.Dev.Biol.32. 127-130 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kohyama, et al.: "Analysis of cytokine producing activity of intestinal intraepithelial T cell from TCR β-chain and δ-chainmutant mice." Microbiol.Immunol.41. 353-359 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yoshida, et al.: "The oral administration of low-dose antigen induces activation followed by tolerization,while high-dose antigen induces tolerance without activation." Clin.Immunol.Immunopathol.82. 207-215 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, et al.: "Enhancing effect of interleukin-4 on the secretion of interferon-γ by α_<s1>-casein-specific CD8^+T cells." Biosci.Biotech.Biochem.61. 1156-1162 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Katakura, et al.: "A small variance in the antigenicity but not function of recombinant β-lactoglobulin purified from the culture supernatant of transformed yeast cells." Cytotechnology. 23. 133-141 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, et al.: "Oral administration of antigen does not influence the proliferation and INF-γ production of responsive CD8^+T cells,but enables us to establishT cell clones with different lymphokineproduction profile." Cytotechnology. 25. 89-100 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, et al.: "Fine mapping of T-cell determinants of bovine β-lactoglobulin." Cytotechnology. 25. 101-110 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, et al.: "Antigen-specific inhibition of CD4^+T-cell responses to β-lactoglobulin by its single amino acid-substituted mutant from through T-cell receptorantagonism." Cytotechnology. 25. 115-126 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ametani, et al.: "A peptide therapy for autoimmunediseases:immunization with a peptide containing a dominant T cell determinant can protect mice from collagen-induced arthritis." Animal Cell Technology:Basic & Applied Aspects. 8. 493-499 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, et al.: "Antiqen-specific inhibition of immune responses by antigen analogs with a single amino acid substitution." Animal Cell Technology:Basic & Applied Aspects. 8. 505-509 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Toda, et al.: "Differential effect of antigen analogs with T cell inhibitory activity on in vivo antibody response." Animal Cell Technology:Basic & Applied Aspects. 9. 91-95 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, et al.: "MHC class H/T cell receptor interactions potentiate secretion of IgG butnot IgM in response to T-dependent antigens." Immunol.Lett.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Matsumoto, et al.: "Intranasal administration of denatured type II collagen and its fragments can delay the onset of collagen-induced arthritis." Clin.Immunol.Immunopathol.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kohyama, et al.: "Selective induction of CD8^+T cell functions by single substituted analogs of an antigenic peptide:distinctsignals for IL-10 production." FFBS Lett.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Nakajima-Adachi, et al.: "Determinant analysis of immunoglobulin E and immunoglobulin G4 antibodies and T cells specific for bovine α_<s1>-casein from the same individual cow's milk patients.Existence of α_<s1>-casein-specific B cells as well as T cells characteristic in cow's milk allergy." J.Allergy Clin.Immunol.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Yoshida, et al.: "Induction of oral tolerance in splenocyte-reconstituted SCID mice." Clin.Immunol.Immunopathol.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 上野川 修一・近藤 直美 編: "食品アレルギー対策ハンドブック" サイエンスフォーラム, 491 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Hirahara, T.Hisatsune, C-Y.Choi and S.Kaminogawa: "Profound Immunological tolerance in the antibody response against bovine alpha_<s1>-casein induced by intradermal administration of a dominant T cell determinant." Clin.Immunol.Immunopathol.76. 12-18 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Hirahara, T.Hisatsune, K.Nishijima, H.Kato, O.Shiho and S.Kaminogawa: "CD4^+ T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferred in SCID and nude mice." J.Immunol.154. 6238-6245 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, T.Hisatsune, H.Kato, O.Shiho and S.Kaminogawa: "alpha_<s1>-casein-specific CD8^+ T cell clone that inhibits its own interferon-gamma production by producing interleukin-10." Biosci.Biotech.Biochem.59. 2274-2276 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, A.Ametani, M.Totsuka, K.Fujie, N.M.Tsuji, J,Kurisaki and S.Kaminogawa: "B cell activation by plasma membranes from activated helper T cells." Animal Cell Technology : Basic & Applied Aspects. 7. 509-514 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Kaminogawa: "Food allergy, oral tolerance and immunomodulation-their molecular and cellular mechanisms." Biosci.Biotech.Biochem.60. 1749-1756 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, A.Ametani, M.Totsuka and S.Kaminogawa: "The direct cloning of the immunoglobulin V_H genes from primary cultured B cells specific for a short peptide." J.Biotechnol.49. 201-210 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Minai, M.Goto, M.Kohyama, T.Hisatsune, K.Nishijima and S.Kaminogawa: "Difference in signal transduction for IL-10 and IFN-gamma production in a CD8^+ T cell clone." Cell.Immunol.172. 200-204 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Nakajima, S.Hachimura, S.Nishiwaki, T.Katsuki, N.Shimojo, A.Ametani, and S.Kaminogawa: "Establishment and characterization of alpha_<s1>-casein-specific T-cell lines from patients allergic to cow 's milk : Unexpected higher frequency of CD8^+ T cell lines." J.Allergy Clin.Immunol.97. 1342-1349 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ametani, A.Imaoka, S.Hachimura, H-K.Yi, Y.Yamamoto, K.Hashimoto, M.Shimizu and S.Kaminogawa: "Consecutive events of growth, differentiation and death of the small intestinal epithelial cell line, IEC-6." In Vitro Cell.Dev.Biol.32. 127-130 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kohyama, S.Hachimura, M.Nanno, H.Ishikawa and S.Kaminogawa: "Analysis of cytokine producing activity of intestinal intraepithelial T cells from TCR beta-chain and delta-chain mutant mice." Microbiol.Immunol.41. 353-359 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Yoshida, S.Hachimura and S.Kaminogawa: "The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation." Clin.Immunol.Immunopathol. 82. 207-215 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, M.Kohyama, T.Hisatsune, H.Kato, M.Kakehi and S.Kaminogawa: "Enhancing effect of interleukin-4 on the secretion of interferon-gamma by alpha_<s1>-casein-specific CD8^+ T cells." Biosci.Biotech.Biochem.61. 1156-1162 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Katakura, M.Totsuka, A.Ametani, and S.Kaminogawa: "A small variance in the antigenicity but not function of recombinant beta-lactoglobulin purified from the culture supernatant of transformed yeast cells." Cytotechnology. 23. 133-141 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Nishijima, T.Hisatsune, H.Kato, M.Kohyama, M.Kakehi, S.Hachimura and S.Kaminogawa: "Oral administration of antigen does not influence the proliferation and IFN-gamma production of responsive CD8^+ T cells, but enables us to establish T cell clones with different lymphokine production profile." Cytotechnology. 25. 89-100 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, A.Ametani and S.Kaminogawa: "Fine mapping of T-cell determinants of bovine beta-lactoglobulin." Cytotechnology. 25. 101-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, S.Furukawa, E.Sato, A.Ametani and S.Kaminogawa: "Antigen-specific inhibition of CD4^+ T-cell responses to beta-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism." Cytotechnology. 25. 115-126 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ametani, T.Matsumoto, A.Iwaya, H.Kano, A.Honda, S.Hachimura, T.Nakagami, S.Kaminogawa: "A peptide therapy for autoimmune diseases : immunization with a peptide containing a dominant T cell determinant can protect mice from collagen-induced arthritis." Animal Cell Technology : Basic & Applied Aspects. 8. 493-499 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Totsuka, M.Toda, S.Furukawa, A.Ametani, and S.Kaminogawa: "Antigen-specific inhibition of immune responses by antigen analogs with a single amino acid substitution." Animal Cell Technology : Basic & Applied Aspects. 8. 505-509 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Toda, M.Totsuka, T.Yoshioka, A.Ametani, and S.Kaminogawa: "Differential effect of antigen analogs with T cell inhibitory activity on in vivo antibody response." Animal Cell Technology : Basic & Applied Aspects. 9. 91-95 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Takahashi, A.Ametani, M.Totsuka, K.Fujine, N.M.Tsuji, J.Kurisaki and S.Kaminogawa: "MHC class II/T cell receptor interactions potentiate secretion of IgG but not IgM in response to T-dependent antigens." Immunol.Lett.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Matsumoto, A.Ametani, S.Hachimura, A.Iwaya, Y.Taguchi, K.Fujita, T.Shigehisa, and S.Kaminogawa: "Intranasal administration of denatured type II collagen and its fragments can delay the onset of collagen-induced arthritis." Clin.Immunol.Immunopathol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kohyama, M.Kakehi, M.Totsuka, S.Hachimura, T.Hisatsume, S.Kaminogawa: "Selective induction of CD8^+ T cell functions by single substituted analogs of an antigenic peptide : distinct signals for IL-10 production." FEBS Lett.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Nakajima-Adachi, S.Hachimura, W.Ise, K.Honma, S.Nishiwaki, M.Hirota, N.Shimojo, T.Katsuki, A.Ametani, Y.Kohno, and S.Kaminogawa: "Determinant analysis of immunoglobulin E and immunoglobulin G4 antibodies and T cells specific for bovine d_<s1>-casein from the same individual cow's milk patients. Existence of d_<s1>-casein-specific B cells as well as T cells characteristic in cow's milk allergy." J.Allergy Clin.Immunol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Yoshida, S.Hachimura, K.Hirahara, T.Hisatsune, K.Nishijima, A.Shiraishi, S.Kaminogawa: "Induction of oral tolerance in splenocyte-reconstituted SCID mice." Clin.Immunol.Immunopathol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Kohyama et al.: "Selective induction of CD8^+T cell functions by single substituted analogs of an antigenic peptide : distinct signals for IL-10 production." FEBS Letters. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Nakajima-Adachi et al.: "Determinant analysis of immunoglobulin E and immunoglobulin G4 antibodies and T cells specific for bovine α-casein from the same individual cow's milk patients. Existence of α_<S1>-casein-specific B cells as well as T cells characterictic in cow's milk allergy." J.Allergy Clin.Immunol.(印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Yoshida et al.: "Induction of oral tolerance in splenocyte-reconstituted SCID mice." Clin.Immunol.Immunopathol.(印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Matsumoto et al.: "Intranasal administration of denatured type II collagen sand its fragments cam delay the onset of collagen-induced arthritis." Clin.Immunol.Immunopathol.(印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Nishijima et al: "Oral administraion of antgen does not influence the proliferation and IFN-γ prodiction of responsive CD8^+ cells,but enables us to establish T cell clones with different cytokine profile." Cytotechnology. 25. 89-100 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Totsuka et al.: "Antigen-specific in inhibition of CD4^+T-cell responses to β-lactoglobulin by its substituted mulant form through T-cell receptor antagonism." Cytotechnology. 25. 115-126 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Nakajima et al.: "Establishment and characterization or α_<S1>-casein-specific T-cell lines from patients allergic to cow's milk:Unexpected higher frequency of CD8^+T-cell lines" J.Allergy Clin.Immunal.97. 1342-1349 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Yoshizawa et al.: "In vitro macrophage-stimulation activity of the enzyme-degraded water-soluble polysaccharide fraction from a marine alga(Gracilavia verrucosa)" Biosci.Biotech.Biochem.60. 1667-1671 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Takahashi et al.: "The direct cloning of the immunoglobulin V_H genes from primary cultured B cells specific for a short peptide" J.Biotechnology. 49. 201-210 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Kaminogawa: "Food allergy,oral tolerance and immunomodulation-their molecular and celler mechanisms" Biosci.Biotech.Biochem.60. 1749-1756 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Minai et al.: "Difference in signal transduction for IL-10 and IFN-γ production in a CD8^+T cell clone" Cell.Immunal.172. 200-204 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Katakura et al.: "A small variance in the antigenicity but not function of recombinant β-lactoglobulin purified from the culture supematant of transformed yeast cells" Cytotechnal. (印刷中).

    • Related Report
      1996 Annual Research Report
  • [Publications] Takahashi,Y.et.al.: "The direct cloning of the immunoglobulin VH genes from primary cultured B cells specific for a short peptide." J.Biotechnol.(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakajima,H.et.al.: "Establishment and characterization α_<s1>-casein-specific T cell lines from patients allergic to cow's milk:unexpected higher frequency of CD8+T-cell lines." J.Allergy Clin.Immunol.(印刷中). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirahara,K.et.al.: "CD4^+T cells anergized by high dose feeding establish oral tolerance to antibody responses when transferred in SCID and nude mice." J.Immunol.154. 6238-6245 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hirahara,K.et.al.: "Profound immunological tolerance in the antibody response against bovine α_<s1>-casein induced by intradermal administration of a dominant T cell determinant." Clin.Immunol.Immunopathol.76. 12-18 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nishijima,K.et.al.: "α_<s1>-casein-specific CD8^+T cell clone that inhibits its own interferon-Y production by producing IL-10." Biosci.Biotech.Biochem.59. 2274-2276 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hisatsune,T.et.al.: "CD8^+T cells specific to the exogenous antigen:mode of antigen recognition and possible implication in immunosuppression." J.Immunol.154. 88-96 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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