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宇宙長期滞在模擬の生理的変化を人工重力の遠心負荷で予防出来るか

Research Project

Project/Area Number 07407013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNihon University

Principal Investigator

YAJIMA Kazuyoshi  Nihon University, School of Medicine, Professor, 医学部, 教授 (40010029)

Co-Investigator(Kenkyū-buntansha) HIRAYANAGI Kaname  Nihon University, School of Medicine, Instructor, 医学部, 講師 (20189864)
ITO Masao  Tokyo University for Agriculture, Faculty of Bioindustry, Professor, 生産産業学部, 教授 (40059887)
MIYAMOTO Akira  Nihon University, School of Medicine, Assistant Professor, 医学部, 助教授 (40150271)
OZAWA Yukio  Nihon University, School of Medicine, Professor, 医学部, 教授 (80059245)
NAKAYAMA Kiyoshi  Sophia University, Department of Science and Engineering, Professor, 理工学部, 教授 (00053653)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 1997: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1996: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 1995: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywords6 degrees head down tilt / stop hematocrit increase / short arm human centrifuge / artificial gravity / long term space flight / cardiovascular countermeasure / space medicine research / 地上での無重量模擬 / 宇宙循環系変化の対策 / 人工重力 / 6度ヘッドダウン(HDT) / 2G1時間の遠心負荷 / 短腕遠心機 / 人間用小型遠心機 / 訓練効果 / 下半身陰圧負荷 / 連続血圧 / R-R間隔 / 圧受容体反射感受性 / 宇宙飛行 / ヘッドダウン臥床実験 / 宇宙ステーション / 対策 / 下肢インピーダンス
Research Abstract

4 days 6 degrees head down tilt bed rest (HDT) experiments were conducted for 10 healthy male students at Nihon University School of Medicine. By a courtesy of Shimizu Co., a 1.8 m radius human centrifuge was set at their Space Development Laboratory and the above mentioned HDT facilitiy was atatched next to the centrifuge room. 10 subjects were kept under a severe control to keep the HDT 24 hours except 15 minutes of secretion and one hour of 2Gz+ centrifugation every day. From many HDT studies up to the present, it has been clear that only hematocrit significantly increases among many physiological changes according to 4 days HDT.
No significant increase was observed among the averaged hematocrit values during the 4 days HDT.By other countermeasures as walking arround or standind on the bed (lG load simulation) for up to 2 hours in 4 days HDT, conducted by Convertino et al., hematocrit increase could not be intercepted. This report is the first deta of short arm centrifuge, proving that the centrifugation is more effective than other countermeasures to inhibit the hematocrit increase normally induced in 4 days HDT on the ground. Considering these facts, centrifugation is the first choice to be adopted for artificial gravity in a long term space life, compared with the other countermeasures such as some exercises or other conventional ways to prevent the physiological changes due to the microgravity condition in space.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Iwasaki,K.,Suzuki,H.,Yajima,K.,et al.: "Parasympathetic Nervous Activity after Administration of Atropine and Neostigmine Using Heart Rate Spectral Analysis" Journal of Anesthesia. 11. 22-27 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 飯田良司、谷島一嘉他: "4つの異なる体位における自律神経機能と圧受容器反射感受性の推定" 宇宙航空環境医学. 34(1). 1-9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 谷島一嘉: "宇宙医学とストレス" ストレス科学. 12(2). 21-24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 谷島一嘉: "6度HDTにおける循環系デコンディショニングの対策としてのGz遠心負荷の効果" 宇宙環境利用フロンティア共同研究成果概要. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki,K.,Igarashi,M.,Yajima,K.,et al.: "Effects of Repeated Long Duration +2Gz Load on Man′s Cardiovascular Function" Acta Astronautica. 42(1-8). 175-183 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasaki,T.,Miyamoto,A.,Yajima,K.,et al.: "Usefulness of a Short-radius Human Centrifuge as a Countermeasure against Cardiovascular Deconditioning during Simulated Weightless" Proceeding of the 21st ISTS. 2. 1727-1732 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki, K., Suzuki, H., Yajima, K., et al.: "Parasympathetic Nervous Activity after Administration of Atropine and Neostigmine Using Heart Rate Spectral Analysis" Journal of Anesthesia. 11. 22-27 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iida, R., Yajima, K., et al.: "Evaluation of Autonomic Nervous Function and Barorecepter Reflex Sensitivity in Four Body Postures" Japanese Journal of Aerospace and Enviromental Medicine. 34-1. 1-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yajima, K.: "Space Medicine and Stress" Japanese Journal of Stress Sciences. 12-2. 21-24 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yajima, K.: "Usefulness of +Gz Load Used as a Countermeasure against Cardiovascular Deconditioning after Head-down-tilt Bed Rest" Reports on Japan Space Utilization Promotion Frontiers Joint Research Program. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki, K., Igarashi, M., Yajima, K., et al.: "Effects of Repeated Long Duration +2Gz Load on Man's Cardiovascular Function" Acta Astronautica. 42-1-8. 175-183 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sasaki, T., Miyamoto, A., Yajima, K., et al.: "Usefulness of a Short-radius Human Centrifuge as a Countermeasure against Cardiovascular Deconditioning during Simulated Weightlessness" Proceeding of the 21st ISTS. 2. 1727-1732 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iwasaki,K.,Suzuki,H.,Yajima,K.et al.: "Parasympathetic Nervous Activity after Administration of Atropine and Neostigmine Using Heart Rate Spectral Analysis" Journal of Anesthesia. 11. 22-27 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 村井亮一、谷島一嘉他: "運動回復期の自律神経活動と運動特性、体型の関係" 日本人間工学会第38回大会抄録集. 316 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 喜多清、谷島一嘉他: "哺乳動物の生殖機能に関する重力依存性" 宇宙利用シンポジウム抄録集. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 谷島一嘉: "宇宙医学とストレス" ストレス科学. 12(2). 21-24 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 谷島一嘉: "6度HDTにおける循環系デコンディショニングの対策としてのGz遠心負荷の効果" 宇宙環境利用フロンティア共同研究成果概要. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岩崎賢一,谷島一嘉,他: "人工重力負荷の循環調節機能に与える影響" 宇宙航空環境医学. (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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