| Project/Area Number |
07407037
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Saitama Medical School |
|---|
Principal Investigator |
OMOTO Ryozo Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (80112647)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Naomasa Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 助手 (10239444)
HUJIUCHI Nobuko Saitama Medical School, Faculty of Medicine, Assistant in Surgery, 医学部, 助手 (70286087)
MATSUMURA Makoto Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (40190508)
KYO Shunnei Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (30153232)
|
|---|
| Project Period (FY) |
1995 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥21,400,000 (Direct Cost: ¥21,400,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1995: ¥14,300,000 (Direct Cost: ¥14,300,000)
|
|---|
| Keywords | Intravascular Ultrasound System / IVUS / Intracardiac Ultrasound / Color Doppler / Cardiovascular Surgery / Mechanically rotated transducer / IVUS with Color Doppler / 超音波ビーム方向 / 循環のシュミレーション回路 / 循環のシミュレーション回路 |
|---|
| Research Abstract |
The efficacy of intravascular ultrasound(IVUS) in the detection of intraluminal thrombi, vessel dissection, or for the estimation of blood flow dynamics is limited. Some of these limitations could be overcome if a new IVUS system could simultaneously provide data about flow velocity and flow volume in the vessels. The main purposes of this research were firstly to develop a new Intravascular Ultrasound System combined with Color Doppler Flow Imaging Systems, secondly to evaluate the feasibility of newly developed "IVUS system" for visualizing blood flow and quantifying flow velocity and volume, and finally to study the possibility of clinical use in Cardiovascular Surgery. In vitro experiments were performed using circulation flow model. The static flows with various velocity (0-l50cm/sec) were produced by altering rotation rate of a centrifugal pump. The transducer was placed at center of a flow tube. The new IVUS system consists of a commercially available color Doppler ultrasound un
… More
it, a 8F IVUS catheter which a 10MHz mechanically rotated transducer was mounted obliquely (45 degree) on the tip of catheter. It rotates at a rate of 5 to 10 cycles/sec. Two-dimensional flow images were displayed in the same way as conventional color Doppler techniques. The color Doppler images have been obtained in flows with velocity over 2 cm/sec. The color tone turned at velocity indication aliasing. The mean velocities obtained by color Doppler significantly correlate with those measured by pulsed wave Doppler (r=0.9998, p<less than or equal>0.O1) and electromagnetic flow meter (r=0.943, p<less than or equal>0.01) respectively. After the confirmation of safety and effectiveness of the new color Doppler catheter in in-vitro experiment, we studied the capability of the new system in three pigs and two patients with dissecting aneurysm. The results demonstrated the clinical feasibility especially in aortic diseases. It is our conclusion that this new system which combined IVUS with color Doppler technique is potentially useful for detection of abnormal blood flow in the vessel lumen, quantification of flow velocity and volume and estimation of flow dymanics, and should advance diagnostic capability of conventional IVUS in application of cardiovascular surg Less
|
