| Project/Area Number |
07407048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gunma University |
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Principal Investigator |
SHIMIZU Koichi Gunma University, Sch of Medicine, Professor, 医学部, 教授 (10009946)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTSUKA Kenichi Gunma University, Sch of Medicine, Instructor, 医学部, 教務員 (90272252)
KISHI Shoji Gunma University, Sch of Medicine, Assistant Professor, 医学部, 講師 (30125843)
MURAOKA Kanemitsu Gunma University, Sch of Medicine, Associate Professor, 医学部, 助教授 (10092008)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥12,000,000 (Direct Cost: ¥12,000,000)
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| Keywords | Optical Coherence Tomography / Scanning Laser Ophthalmoscope / macular hole / preretinal macular fibrosis / macular edema / retinal thickness / glaucoma / excavation of optic nerve head / SLO / 光学干渉断層計 / 生体組織学 / 多局所網膜電図 / 光学的網膜断面撮影 |
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| Research Abstract |
Scanning laser ophthalmoscope (SLO) allows an enhanced image of superficial and deeper retinal layr observed by argon and helium-neon laser respectively.
Optical coherence tomography (0CT) provides an cross-sectional image of the retina with 10-20 um resolution. We studied "the histology in vivo" of various fundus diseases with OCT alone or with OCT and SLO.
1) SLO showed an elevation of the Henle's fiber layr is an initial change in macular hole development. It was observed as the retinoschisis at the fovea with OCT.Operculua was formed by thin retinal tissue detached from the retinal pigment epithelium at the fovea. 2) SLO clearly demonstrated the epiretinal membrane and surperficial retinal folds by argon and helium-neon laysers. OCT revealed unexpected retinal thickning particularly at the outer retina. 3) OCT demonstrated the three pattern of macular edema which included a sponge-like swelling, cystoid edema and serous retinal detachment. 4) The cross-sectional image of age-related macular degeneration showed the increased reflectivity of subretinal pigment epithelial space according to the evolution of the lesion from RPE detachment to the disciform degeneration with choroidal neovascularization. 5) OCT showed decreased reflectivity of the retina in heigh myope with posterior staphloma. As elongation of the optical axis, retinoschisis may develop at the macula. 6) OCT demonstrated the detached retina may develop tissue swelling.
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