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STUDIES ON INTRACTABLE ORAL MUCOSAL LESIONS

Research Project

Project/Area Number 07407057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionDOKKYO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

FUJIBAYASHI Takashi  Dokkyo University School of Medicine, Professor, 医学部, 教授 (80013978)

Co-Investigator(Kenkyū-buntansha) AZUMA Miyuki  Juntendo University, School of Medicine, Instructor, 医学部, 助手 (90255654)
ASAKURA Setsuko  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (60296134)
SHIODA Yoshimi  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (40285862)
SHINOHARA Makoto  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (10245102)
SASAKI Tadaaki  Dokkyo University School of Medicine, Lecturer, 医学部, 講師 (40225876)
冨塚 謙一  獨協医科大学, 医学部, 助手 (30306188)
Project Period (FY) 1995 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1997: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1995: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsOral Mucosal Lesions / Intractable Disease / Immunological Study / Costimulatory Molecules / Prognostic Determinant Factor / Oral Precancerous Lesion / Sjogren's Syndrome / Diagnostic Criteria / 難治性口腔粘膜疾患 / 口腔乾燥症 / 診断精度 / 口腔扁平苔癬 / 早期癌 / 前癌病変 / シェ-グレン症候群 / 診断基準の精度 / 再発性アフタ / アミロイドーシス / 生検病理組織 / 口腔検査 / 眼科検査 / 診断の感度 / 診断の特異度 / ベーチェット病
Research Abstract

1. Immunological investigation on intractable oral mucosal lesions with special focus on oral mucosal cancers The cytotoxic activities of anti-CD3 induced LAX ceUs were sbicied with oral scwmous cell carcinoma derived target cells after preincubation with chemotherapeutic reagents such as CDDP, 5FU, PEP, BLM.The cytotoxic activity varied with reagent applied, HLA class I, II expression also showed some variations.
2. lrrvestigation on immunological response through coslimulatory molecules in intractable oral , mjcosal lesions Mouse model of hapten induced contact dermatitis were studied. Strong increase of CD86 expression on Langerharis cells and some increase of CD8O, CD86 both positive cells were observed after skin sensitization. The skin reaction was depressed by ackninistration of anti-CTLA-4 antibody.
3. Investigation on prognosis of intractalAe oral mucosal lesions Multivariate evaluation of prognostic determinant factors for oral squamous cell carcinomas using Cox'proportional ha … More zards model revealed that pattern of invasion in histopathology, T classification, treatment modality were most significant prognostic factors. Other oral mucosal lesions such as oral precancerous lesions like oral letkoplakia, oral precancerous condition related lesions like oral lichen planus were also studied.
4. Investigation on clinical features of intractable oral mucosal lesions Clinical featres of Siogrerfssynch-ome and xerostomia were mostly investigated. Diagnostic criteria for Siogren's syndrome play key role for differential diagnosis of the both diseases. Head investigator attended working cornmrttee for revision of Jaanese diagnosbc cnteria in Japanese Association for Sjogren's Synckome. Total number of 823 cases of Siogren's synciome inducing normal control was assayed for sensitivity and specificity in diagnosis using various revised criteria. Final revised diagnostic criterion for Siogreri's syndome has completed through discussion in Japanese Association for Sjogren's syndrome. Less

Report

(5 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Takashi Fujibayashi: "Comparative study on sensitivity and Specificity of various diagnostic criteria of Sjogren's syndrome." Clinical Rheumatology. 14. suppl 1. 21-22 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Azuma, M., Lanier, L. L.: "The role of CD28 Costimulation in the generation of cyfatoxic T lymphocytes" Curr. Topics Microbiol. Immunol.198. 59-74 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nuriya, S.Azuma, M.et al.: "The differential role of CD86 and CD80 Costimulatory mdeules in the indcution and effector phase of contact hypersensitivity" Int, Immunol.8. 917-926 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi, et al: "Preliminary revision of the Japanese criteria for Sjogren's syndrome" J, Rheumatol.24. 38-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tadaaki Sasaki: "Multivariate evaluation of prognostic determinant factors for oral squanous cell carcinomas" Dokkyo J.Med.Sci.24・2. 109-115 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 藤林孝司: "シェーグレン症候群に関する最近の研究展望" 日本口腔粘膜学会雑誌. 4・2. 75-90 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 藤林孝司: "総合口腔診断学" 砂書房, 1-645 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 藤林孝司: "リウマチ'97" メディカルレビュー社, 1-239 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Comparative study on senssitivity and specificity of various diagnostic criteria for Sjogren's syndrome." Clinical Rheumatology. 14-suppl.1. 21-22 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyuki Azuma: "The role of CD28 costimulation in the generation of cytotoxic T lymphocytes." Current Topics in Microbiology and Immunology. 198. 59-74 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Oral cavity and immune responses." Journal of Otolaryngology, Head and Neck Surgery. 12-1. 63-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nuriya, S.: "The differential role of CD86 and CD80 costimulatory molecules in the induction and effector phase of contact hypersensitivity." International Immunology. 8. 917-926 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Comparative study on various classification criteria of Sjogren's syndrome." Journal of Japanese Society for Oral Mucous Membrane. 2-1. 60-68 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Immunotherapy of cancer." Dental Outlook. 88-6. 1363-1372 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nobuyuki Miyasaka: "Ishiyaku Publisshers, Inc." Intractable conditions in connective tissue disease. 1-114 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Proposal of revised diagnostic criteria for Sjogren's syndrome." Report of Research Committee on Autoimmune Diseases in the Ministry of Health and Welfare. 58-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Diagnostic criteria for xerostomia especially for Sjogren's syndrome." the Quintessence. 16-5. 1063-1072 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Drug therapy of oral lichen planus." The Journal of Practical Pharmacy. 48-6. 891-897 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "Preliminary revision of the Japanese criteria for Sjogren's syndrome." Journal of Rheumatology. 24. 38-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tadaaki Sasaki: "A study on prognostic factors for survival in patients with head and neck squamous cell carcinomas by multivariate analysis." Oral Oncology. 5. 120-123 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tadaaki Sasaki: "Mutivariate evaluation of prognostic deter-minant factors for oral squamous cell carcinomas." Dokkyo Journal of Medical Science. 24-2. 109-115 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Fujibayashi: "A review of recent studies on Sjogren's syndrome." Journal of Japanese Society for Oral Mucous Membrane. 4-2. 75-90 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujibayashi,T.,Sugai,S.,Miyasaka,N.et al.: "Accuracy of Japanese versus European diagnostic criteria for Sjognen's syndrome" European Association of Cral Medicine 4th meeting,Final program and Abstracts. Abstract. 27-27 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takashi Fujibayashi: "Immunological consideration of oral mucosal lesions" Xth National Cenference of Indian Academy of Oral Medicine. Abstract. 11-11 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 藤林孝司: "シェーグレン症候群に関する最近の研究展望" 日本口腔粘膜学会雑誌. 4・2. 75-90 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 藤林孝司,菅井進ほか: "シェーグレン症候群診断基準改訂試案に対する再検討" 日本口腔粘膜学会雑誌. 4・2. 149-150 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 藤林孝司ほか: "シェーグレン症候群診断基準改訂試薬に対する再々検討" 第8回日本シェーグレン症候群研究会プログラム抄録集. 28-37 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 藤林 孝司: "口腔乾燥症の診断のクライテリアシェ-グレン症候群を中心に" the Quintessense. 16・5. 1063-1072 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤林 孝司: "口腔扁平苔癬の薬物療法" 薬局. 48・6. 891-897 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 後藤 聡, 森田浩章, 朴 忠君, 藤林孝司: "白板症様病変より発見された舌早期癌の1例" 栃木県歯科医学誌. 49. 69-72 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 横倉幸弘, 上地江美里, 渡辺八州郎, 朴 忠君, 室井和子, 藤林孝司: "舌病変により発見された全身性アミロイドーシスの1例" 日本口腔粘膜学会雑誌. 3・2. 88-92 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tadaaki Sasaki: "Multivariate evaluation of prognostic deter-minant factors for oral squamous cell carcinomas" Dokkyo Journal of Medical Sciences. 24・2. 109-115 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤林孝司, 菅井進, 宮坂信之, 東條毅, 宮脇昌二, 市川幸延, 坪田一男: "リウマチ'97(分担主題名:シェ-グレン症候群診断基準の改訂)" メディカルレビュー社, 239 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤林孝司: "シェ-グレン症候群診断基準の改訂試案" 厚生省特定疾患自己免疫疾患調査研究班平成7年度研究報告書. 58-60 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 倉林亨: "耳下腺腫瘍が疑われたシェ-グレン症候群のCT所見" 歯科放射線. 36・1. 14-21 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "シェ-グレン症候群の免疫" the Quintessense. 15・4. 766-770 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "シェ-グレン症候群の各種診断基準に関する比較検討" 日本口腔粘膜学会雑誌. 2・1. 60-68 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "癌の免疫療法" 歯界展望. 88・6. 1363-1372 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "総合口腔診断学" 砂書房, 645 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "膠原病の難治性病態" 医歯薬出版, 114 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 藤林孝司: "口腔乾燥症(Sjogren's syndrome)" 医学のあゆみ. 173. 101-106 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤林孝司: "歯科臨床におけるシェーグレン症候群の診断と治療" ザ・クインテッセンス. 14. 848-861 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Fujibayashi: "Comparative study on sensitivity and specificity of various diagnostic criteria of Sjogren's syndrome" Clinical Rheumatology. 14 Suppl.1. 21-22 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤林孝司: "口腔と免疫応答" Journal of Otolaryngology, Head and Neck Surgery. 12. 63-69 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 東みゆき: "CD28シグナル阻害による免疫寛容の導入" 臨床免疫. 27. 1078-1082 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 東みゆき: "T細胞活性化におけるcostimulatory分子" 感染・炎症・免疫. 25-3. 168-176 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤林孝司: "歯科におけるくすりの使い方" デンタルダイアモンド社, 316 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤林孝司: "1996今日の治療指針" 医学書院, 1435 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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