| Project/Area Number |
07407068
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Juntendo University School of Medicine |
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Principal Investigator |
OKUMURA Ko Juntendo Univ.Sch.of Med.Prof., 医学部, 教授 (50009700)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Kazunori Juntendo Univ.Sch.of Med.Prof., 医学部, 助手 (60233780)
YAGITA Hideo Juntendo Univ.Sch.of Med.Prof., 医学部, 助教授 (30182306)
東 みゆき 順天堂大学, 医学部, 助手 (90255654)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1996: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | LFA / TNF / TNF-R / monoclonal antibody / anergy / FasL / パ-フォリン / ジーンターゲッティン / CD80,CD86 / TNF / TNF-R / CD27 / GVHD / CD95L / CD80 / CD86 / 寛容 / Th1 / Th2 / CTLA-4 / アナジー / エイズ |
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| Research Abstract |
We have been studied the biological significance of cell to cell interactions depending on various lymphocyte factioning molecules belonging to Ig-super family molecules and/or TNF/TNF-R family molecules. Especially utilizing monoclonal antibodies to various LFA molecules involved in the initiation of immune response, we found that the some LFA are extremely associated to the T cell activation as well as T cell anergy.
Regarding to the molecules involved in effector phase of immune response, we found that TNF/TNF-R interaction is fully involved in the immunological disorders. Addition, our original monoclonal antibodies against such molecules are now widely used in many labs.
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