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Studies on the differention and activation mechanisms of T cell vi lymphocye functioning antigen (LFA).

Research Project

Project/Area Number 07407068
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionJuntendo University School of Medicine

Principal Investigator

OKUMURA Ko  Juntendo Univ.Sch.of Med.Prof., 医学部, 教授 (50009700)

Co-Investigator(Kenkyū-buntansha) KATO Kazunori  Juntendo Univ.Sch.of Med.Prof., 医学部, 助手 (60233780)
YAGITA Hideo  Juntendo Univ.Sch.of Med.Prof., 医学部, 助教授 (30182306)
東 みゆき  順天堂大学, 医学部, 助手 (90255654)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1996: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsLFA / TNF / TNF-R / monoclonal antibody / anergy / FasL / パ-フォリン / ジーンターゲッティン / CD80,CD86 / TNF / TNF-R / CD27 / GVHD / CD95L / CD80 / CD86 / 寛容 / Th1 / Th2 / CTLA-4 / アナジー / エイズ
Research Abstract

We have been studied the biological significance of cell to cell interactions depending on various lymphocyte factioning molecules belonging to Ig-super family molecules and/or TNF/TNF-R family molecules. Especially utilizing monoclonal antibodies to various LFA molecules involved in the initiation of immune response, we found that the some LFA are extremely associated to the T cell activation as well as T cell anergy.
Regarding to the molecules involved in effector phase of immune response, we found that TNF/TNF-R interaction is fully involved in the immunological disorders. Addition, our original monoclonal antibodies against such molecules are now widely used in many labs.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (114 results)

All Other

All Publications (114 results)

  • [Publications] Noto. K., et al.: "Identification and functional characterization of mouse CD29 with a mAb." Int. Immunol.7. 835-842 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Lanier, L. L., et al.: "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL^1." J. Immunol.154. 97-105 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda, M., et al.: "Expression and function of fibronectin binding integrins on rat mast cells." Int. Immunol.7. 251-258 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Azuma, A., et al.: "Augmented lung adenocarcinoma cytotoxicity by the combination of a genetically modified anti-Lewis Y antibody and antibodies to complement regulatory proteins." Scand. J. Immunol.42. 202-208 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ushiyama, C., et al.: "Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantaion." J. Immunol.154. 2687-2696 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yagita, H., et al.: "Fas-mediated cytotoxicity-a new immunoregulatory and pathogenic function of Thl CD4^+ T cells." Immunological Reviews. 146. 223-239 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "CD86 (B70 / B7-2) on endothlial cells co-stimulates allogeneic CD4^+ T cells." Int. Immunol.7. 1331-1337 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, T., et al.: "Involvement of αl and α4 integrins in gut mucosal injury of graft-versus-host disease." Int. Immunol.7. 1183-1189 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki, N. et al.: "Metalloproteinase-mediated release of human Fas ligand." J. Exp. Med.182. 1777-1783 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Preferential dependence of autoantibody production in murine lupus on CD86 co-stimulatory molecule." Eur. J. Immunol.25. 3060-3069 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Induction of persistent allograft tolerance in the rat by combined treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies, donor specific transfusion, and FK506." Transplantation.6. 117-122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yonezawa, I., et al.: "VLA-5 mediated interaction with fibronectin induces cytokine production by human chondrocytes." Biochem. Biophys. Res. Commun.219. 261-264 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yagita, H., et al.: "CD95 ligand in graft rejection." Nature.379. 682 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato, K., et al.: "Local production of IL-12 p40 suppresses Thl-mediated immune responsed and prevents allogeneic myoblast rejection." Proc. Natl. Acad. Sei. USA.93. 9085-9089 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Specific acceptance of cardiac allografts after treatment with antibodies to CD80 and CD86 in mice." Transplantaion.28. 1039-1041 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nuriya, S., et al.: "The differential role of CD86 and CD80 costimulatory molecules in the induction and the effector phases of contact hypersensitivity." Int. Immunol.8. 917-926 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakano, H., et al.: "TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor." J. Biol. Chem.271. 14661-14664 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hamamura, K., et al.: "A critical role of VLA-4 in erythropoiesis in vivo." Blood.6. 2513-2517 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Contribution of Fas ligand to cardiac allograft rejection." Int. Immunol.6. 1347-1354 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takazawa, K., et al.: "Synergistic effects of mycophenolate Mofetil (MMF, RS-61443) and anti-LFA-1 / monoclonal antibodies on the prolongation of heart allograft survival in rats." Transplantation. 28. 1980-1981 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sekine, C., et al.: "Fas-mediated stimulation induces IL-8 secrtion by rheumatoid arthritis synoviocytes independently of CPP32-mediated apoptosis." Biochem. Biophys. Res. Commun.,. 228. 14-20 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito, K., et al.: "Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-vesus-host disease." Eur. J. Immunol.26. 3098-3106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kaneko, H., et al.: "Preferential elimination of CD28^+ T cells insystemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis." Clin. Exp. Immunol.106. 218-229 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kaneko, Y., et al.: "CD40-mediated stimulation of B1 and B2 cells : Implication in autoantibody production in murine lupus." Eur. J. Immunol.26. 3061-3065 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Lack of cognate help by CD4^+ T cells and anergy of CD8^+ T cells are the principal mechanisms for anti-leukocyte function-associated antigen-1 / intercellular adhesion molecule-1-induced cardiac allograft tolerance." Transpl antation. 63. 113-118 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Roles of IL-4 and IL-12 in the development of lupus in NZB/WF 1 mice." J. Immunol.158. 1466-1472 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Antiumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Rejection of Fas Ligand-Expressing Grafts." Transpolant. Proc.29. 1092-1093 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki, N., et al.: "Polymorphism of murine Fas ligand that affects thebiological activity." Proc. Natl. Acad. Sci. USA.94. 3914-3919 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoi, H., et al.: "Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12." Eur. J. Immunol.27. 641-646 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells." Int. Immunol.9. 637-644 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori, K., et al.: "A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice." Blood.90. 542-548 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda, K., et al.: "Characterization of rat CD80 and CD86 by molecular cloning and mAb." Int. Immunol.9. 993-1000 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawamura, T., et al.: "Critical role of NK1^+ T cells in IL-12-induced immune resposes in vivo." J. Immunol.160. 16-19 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Noto, K., et al.: "Identification and functional characterization of mouse CD29 with a mAb." Int.Immunol.7. 835-842 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Lanier, L.L., et al.: "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL^1." J.Immunol.154. 97-105 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda, M., et al.: "Expression and function of fibronectin binding integrins on rat mast cells." Int.Immunol.7. 251-258 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Azuma, A., et al.: "Augmented lung adenocarcinoma cytotoxicity by the combination of a genetically modified anti-Lewis Y antibody and antibodies to complement regulatory proteins." Scand.J.Immunol.42. 202-208 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ushiyama, C., et al.: "Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantaion." J.Immunol.154. 2687-2696 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yagita, H., et al.: "Fas-mediated cytotoxicity-a new immunoregulatory and pathogenic function of Th1 CD4^+ T cells." Immunological Reviews. 146. 223-239 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4^+ T cells." Int.Immunol.7. 1331-1337 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, T., et al.: "Involvement of alpha1 and alpha4 integrins in gut mucosal injury of graft-versus-host disease." Int.Immunol.7. 1183-1189 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki, N.et al.: "Metalloproteinase-mediated release of human Fas ligand." J.Exp.Med.182. 1777-1783 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Preferential dependence of autoantibody production in murine lupus on CD86 co-stimulatory molecule." Eur.J.Immunol.25. 3060-3069 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Induction of persistent allograft tolerance in the rat by combined treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies, donor specific transfusion, and FK506." Transplantation. 6. 117-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yonezawa, I., et al.: "VLA-5 mediated interaction with fibronectin induces cytokine production by human chondrocytes." Biochem.Biophys.Res.Commun.219. 261-264 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yagita, H., et al.: "CD95 ligand in graft rejection." Nature.379. 682 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kato, K., et al.: "Local production of IL-12 p40 suppresses Th1-mediated immune responses and prevents allogeneic myoblast rejection." Proc.Natl.Acad.Sci.USA. 93. 9085-9089 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Specific acceptance of cardiac allografts after treatment with antibodies to CD80 and CD86 in mice." Transplantaion. 28. 1039-1041 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nuriya, S., et al.: "The differential role of CD86 and CD80 costimulatory molecules in the induction and the effector phases of contact hypersensitivity." Int.Immunol.8. 917-926 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakano, H., et al.: "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor." J.Biol.Chem.271. 14661-14664 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hamamura, K., et al.: "A critical role of VLA-4 in erythropoiesis in vivo." Blood. 6. 2513-2517 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Contribution of Fas ligand to cardiac allograft rejection." Int.Immunol.8. 1347-1354 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takazawa, K., et al.: "Synergistic effects of mycophenolate Mofetil (MMF,RS-61443) and anti-LFA-1/ monoclonal antibodies on the prolongation of heart allograft survival in rats." Transplantation. 28. 1980-1981 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sekine, C., et al.: "Fas-mediated stimulation induces IL-8 secretion by rheumatoid arthritis synoviocytes independently of CPP32-mediated apoptosis." Biochem.Biophys.Res.Commun.228. 14-20 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Saito, K., et al.: "Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-vesus-host disease." Eur.J.Immunol.26. 3098-3106 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kaneko, H., et al.: "Preferential elimination of CD28^+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis." Clin.Exp.Immunol.106. 218-229 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kaneko, Y., et al.: "CD40-mediated stimulation of B1 and B2 cells : Implication in autoantibody production in murine lupus." Eur.J.Immunol.26. 3061-3065 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Bashuda, H., et al.: "Lack of cognate help by CD4^+ T cells and anergy of CD8^+ T cells are the principal mechanisms for anti-leukocyte function-associated antigen-1/intercellular adhesion molecule-1-induced cardiac allograft tolerance." Transplantation. 63. 113-118 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Roles of IL-4 and IL-12 in the development of lupus in NZB/WF1 mice." J.Immunol.158. 1466-1472 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Antitumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Rejection of Fas Ligand-Expressing Grafts." Transplant.Proc.29. 1092-1093 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki, N., et al.: "Polymorphism of murine Fas ligand that affects the biological activity." Proc.Natl.Acad.Sci.USA. 94. 3914-3919 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yokoi, H., et al.: "Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12." Eur.J.Immunol.27. 641-646 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakajima, A., et al.: "Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells." Int.Immunol.9. 637-644 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori, K., et al.: "A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice." Blood. 90. 542-548 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Maeda, K., et al.: "Characterization of rat CD80 and CD86 by molecular cloning and mAb." Int.Immunol.9. 993-1000 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawamura, T., et al.: "Critical role of NK1^+ T cells in IL-12-induced immune resposes in vivo." J.Immunol.160. 16-19 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Noto,K.,et al.: "Identification and functional characterization of mouse CD29 with a mAb." Int.Immunol.7. 835-842 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lanier,L.L.,et al.: "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation,cytokine production,and generation of CTL^1." J.Immunol.154. 97-105 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yasuda,M.,et al.: "Expression and function of fibronectin binding integrins on rat mast cells." Int.Immunol.7. 251-258 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Azuma,A.,et al.: "Augmented lung adenocarcinoma cytotoxicity by the combination of a genetically modified anti-Lewis Y antibody and antibodies to complement regulatory proteins." Scand.J.Immunol.42. 202-208 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ushiyama,C.,et al.: "Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantaion." J.Immunol.154. 2687-2696 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yagita,H.,et al.: "Fas-mediated cytotoxicity-a new immunoregulatory and pathogenic function of Thl CD4 T cells." Immunological Reviews. 146. 223-239 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Seino,K.,et al.: "CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4^+ T cells." Int Immunol.7. 1331-1337 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka,T.,et al.: "Involvement of α1 and α4 integrins in gut mucosal injury of graft-versus-host disease." Int Immunol.7. 1183-1189 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kayagaki,N.et al.: "Metalloproteinase-mediated release of human Fas ligand." J.Exp.Med.182. 1777-1783 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima,A.,et al.: "Preferential dependence of autoantibody production in murine lupus on CD86 co-stimulatory molecule." Eur.J.Immunol.25. 3060-3069 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Bashuda,H.,et al.: "Induction of persistent allograft tolerance in the rat by combined treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies,donor specific transfusion,and FK506." Transplantation. 6. 117-122 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yonezawa,I.,et al.: "VLA-5 mediated interaction with fibronectin induces cytokine production by human chondrocytes." Biochem.Biophys.Res.Commur.219. 261-264 (1996)

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  • [Publications] Yagita,H.,et al.: "CD95 ligand in graft rejection." Nature.379. 682 (1996)

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  • [Publications] Kato,K.,et al.: "Local production of IL-12 p40 suppresses Th1-mediated immune responses and prevents allogeneic myoblast rejection." Proc.Natl.Acad.Sci.USA.93. 9085-9089 (1996)

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  • [Publications] Bashuda,H.,et al.: "Specific acceptance of cardiac allografts after treatment with antibodies to CD80 and CD86 in mice." Transplantaion.28. 1039-1041 (1996)

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  • [Publications] Nuriya,S.,et al.: "The differential role of CD86 and CD80 costimulatory molecules in the induction and the effector phases of contact hypersensitivity." Int.Immunol.8. 917-926 (1996)

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  • [Publications] Nakano,H.,et al.: "TRAF5,an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor." J.Biol.Chem.271. 14661-14664 (1996)

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  • [Publications] Hamamura,K.,et al.: "A critical role of VLA-4 in erythropoiesis in vivo." Blood. 6. 2513-2517 (1996)

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  • [Publications] Seino,K.,et al.: "Contribution of Fas ligand to cardiac allograft rejection." Int.Immunol.8. 1347-1354 (1996)

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  • [Publications] Takazawa,K.,et al.: "Synergistic effects of mycophenolate Mofetil (MMF,RS-61443) and anti-LFA-1/monoclonal antibodies on the prolongation of heart allograft survival in rats." Transplantation. 28. 1980-1981 (1996)

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  • [Publications] Sekine,C.,et al.: "Fas-mediated stimulation induces IL-8 secretion by rheumatoid arthritis synoviocytes independently of CPP32-mediated apoptosis." Biochem.Biophys.Res.Commun.228. 14-20 (1996)

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  • [Publications] Saito,K.,et al.: "Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-vesus-host disease." Eur.J.Immunol.26. 3098-3106 (1996)

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  • [Publications] Kaneko,H.,et al.: "Preferential elimination of CD28^+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis." Clin.Exp.Immunol.106. 218-229 (1996)

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  • [Publications] Kaneko,Y.,et al.: "CD40-mediated stimulation of B1 and B2 cells : Implication in autoantibody production in murine lupus." Eur.J.Immunol.26. 3061-3065 (1996)

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  • [Publications] Bashuda,H.,et al.: "Lack of cognate help by CD4^+ T cells and anergy of CD8^+ T cells are the principal mechanisms for anti-leukocyte function-associated antigen-l/intercellular adhesion molecule-l-induced cardiac allograft tolerance." Transplantation. 63. 113-118 (1997)

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  • [Publications] Nakajima,A.,et al.: "Roles of IL^^--4 and IL-12 in the development of lupus in NZB/W F1 mice." J.Immunol.158. 1466-1472 (1997)

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  • [Publications] Seino,K.,et al.: "Antitumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

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  • [Publications] Seino,K.,et al.: "Rejection of Fas Ligand-Expressing Grafts." Transplant.Proc.29. 1092-1093 (1997)

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  • [Publications] Kayagaki,N.,et al.: "Polymorphism of murine Fas ligand that affects the biological activity." Proc.Natl.Acad.Sci.USA.94. 3914-3919 (1997)

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  • [Publications] Maeda,K.,et al.: "Characterization of rat CD80 and CD86 by molecular cloning and mAb." Int.Immunol.9. 993-1000 (1997)

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  • [Publications] Kawamura,T.,et al.: "Critical role of NK1^+ T cells in IL-12-induced immune resposes in vivo." The J.Immunol.160. 16-19 (1998)

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  • [Publications] Kayagaki,N.,et al.: "Polymorphism of murine Fas ligand that affects the biological activity." Proc.Natl.Acad.Sci.(in press). (1997)

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  • [Publications] Seino,K.,et al.: "Anti-tumor effect of locally produced Fas ligand." Nature Medicine. 3. 165-170 (1997)

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  • [Publications] Kato,K.,et al.: "Local production of IL-12 p40 suppresses Th1-mediated immune responses and prevents allogeneic myoblast rejection." Proc.Natl.Acad.Sci.93. 9085-9089 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hamamura,K.,et al.: "A critical role of VLA-4 in erythropoiesis in vivo." Blood. 87. 2513-2517 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yagita,H.,et al.: "CD95 ligand in graft rejection." Nature. 379. 682 (1996)

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  • [Publications] Kayagaki,N.,et al.: "Metalloproteinase-mediated release of human Fas ligand." J.Exp.Med.182. 1777-1783 (1995)

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  • [Publications] Nakajima,A.,: "Proferential dependence of autoantibody production in murine lupus on CD86 co-stimulatory molecule." Eur. J. Immunol.25. 3060-3069 (1995)

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  • [Publications] Takazawa,K.,: "CAM-A novel immunosuppressive agant." Transplantation. 59. 1723-1727 (1995)

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  • [Publications] Seino,K.,: "CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4^+ T cells." Int. Immunol.,. 7. 1331-1337 (1995)

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  • [Publications] Tanaka,T.: "Involvement of α1 and α4 integrins in gut mucosal injury of graft-versus-host disease." Int. Immunol.,. 7. 1183-1189 (1995)

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  • [Publications] Kayagaki,N.: "Metalloproteinase-mediated release of human Fas ligand." J. Exp. Med.,. 182. 1777-1783 (1995)

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  • [Publications] Yagita,H.,: "Fas-mediated cytotoxicity-a new immunoregulatory and pathogenic function of Th1 CD4^+ T cells." Immunological Reviews,. 146. 223-239 (1995)

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Published: 1996-04-01   Modified: 2016-04-21  

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