| Project/Area Number |
07408029
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
IKADA Yoshito Institute for Frontier Medical Sciences, Kyoto University, Professor, 再生医科学研究所, 教授 (00025909)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko Institute for Frontier Medical Sciences, Kyoto University, Associate Professor, 再生医科学研究所, 助教授 (50211371)
IWATA Hiroo Institute for Frontier Medical Sciences, Kyoto University, Professor, 再生医科学研究所, 教授 (30160120)
TOMITA Naohide Institute for Frontier Medical Sciences, Kyoto University, Associate Professor, 再生医科学研究所, 助教授 (50263140)
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| Project Period (FY) |
1995 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥22,600,000 (Direct Cost: ¥22,600,000)
Fiscal Year 1998: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1997: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1996: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1995: ¥7,300,000 (Direct Cost: ¥7,300,000)
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| Keywords | Piezoelectricity / Resorbable polymer / Poly (L-lactide) / Magnetic field / Bone formation / Resorption kinetics / Biomaterials for bone fixation / Biomedical engineering / ポリ乳酸 / 生体吸収速度 / 吸収性繊維 / bFGF / TGF-β / ポリ-L-乳酸 / 乳酸重合 / 骨再生 / 頭蓋骨再生 / 顎骨再建 / 吸収性材料 / 分解吸収性高分子 / 生体材料 / 生体吸収性材料 / ピエゾ / 整形外科 / 骨 |
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| Research Abstract |
Electromagnetic regenerators have been clinically used for enhancement of callus formation. In addition, metallic wires and plates have been used in orthopaedic surgery for fixation of fractured bones. The objective of this work was to accumulate scientific information for wider clinical applications of poly(L-lactide(PLLA) which can generate electricity upon being mechanically strained. PLLA is at the same time resorbed in the body when implanted.
The following findings were obtained by this work. 1) Changes of synthetic conditions of PLLA produced PLLA sheet, plate, and fiber with a variety of mechanical properties and resorption kinetics. 2) Incorporation of cell growth factors such as bFGF and TGF-beta in resorbable carriers and subsequent implantation resulted in ectopic bone regeneration as well as in bone formation in native bone tissues. 3) Implantation of a magnetized metal block made from samarium cobalt in the rat femur promoted bone formation, in marked contrast with a non-magnetized samarium cobalt block of the same size. 4) Combination of PLLA fibers and resorbable poIy(epsilon-capro1actone) fibers could readily fix a fractured bone, similar to the conventional metal wire. The fixation of a fractured bone with the resorbable fiber combination could be carried out by heating the po1y(epsilon-capro1actone) fibers above the melting temperature. 5) PLLA fibers could generate electricity when they were twisted and then extended to the fiber direction. This indicates that the assemble of twisted PLLA fibers acquired a piezoelectric property in addition to resorbability in the body.
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